Biphasic effects of exogenous VEGF on VEGF expression of adult neural progenitors.

Abstract:

:Vascular endothelial growth factor (VEGF) regulates neurogenesis. The present study investigated the direct effect of VEGF on the enhancement of proliferation and differentiation of the adult mouse subventricular zone (SVZ) neural progenitors in vitro. A high dose (500 ng/ml) of VEGF significantly downregulated endogenous VEGF receptors 1 and 2, which was associated with significantly reduced neural progenitor cell proliferation and enhancement of neuronal differentiation. A low dose (50 ng/ml) of VEGF significantly upregulated endogenous VEGF receptors 1 and 2 but did not increase proliferation and differentiation. These data suggest that exogenous VEGF has a biphasic effect on the expression of endogenous VEGF receptors, and the high dose of VEGF enhances adult neural progenitor cell differentiation into neurons.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Meng H,Zhang Z,Zhang R,Liu X,Wang L,Robin AM,Chopp M

doi

10.1016/j.neulet.2005.09.044

keywords:

subject

Has Abstract

pub_date

2006-01-30 00:00:00

pages

97-101

issue

2-3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(05)01103-1

journal_volume

393

pub_type

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