Co-localization of neuropeptide tyrosine and somatostatin immunoreactivity in neurons of individual subfields of the rat hippocampal region.

Abstract:

:The co-localization of neuropeptide tyrosine (NPY) and somatostatin (SOM) in rat hippocampal cells was studied in double labelling experiments using a combination of antibodies against the two peptides on the same tissue section. The individual hippocampal subfields show large variations in the relative number of NPY- and SOM-immunoreactive (-i) neurons. While the entorhinal area is far richer in SOM as compared to NPY-i cells, NPY-i cells predominate in all subfields (e.g. regio superior, regio inferior) of Ammon's horn. Co-localization of both peptides in single neurons was highest in regio inferior and in the area dentata and lowest in the retrohippocampal structures. In the dorsal hippocampus, the number of SOM-i cells containing NPY-i was higher than the number of NPY-i cells containing SOM-i. This pattern was reversed in the retrohippocampal region. At ventral levels the incidence of colocalization of NPY- and SOM-i in single cells increased in all hippocampal subfields.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Köhler C,Eriksson LG,Davies S,Chan-Palay V

doi

10.1016/0304-3940(87)90551-9

subject

Has Abstract

pub_date

1987-07-09 00:00:00

pages

1-6

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(87)90551-9

journal_volume

78

pub_type

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