Abstract：
:At postnatal day (PN)1, there are sex differences in gonadal receptor expression in the rat substantia nigra pars reticulata (SNR). Male pups have lower levels of androgen receptor (AR) and estrogen receptor (ER)beta immunoreactivity (IR) compared to female pups, while ERalpha IR is equally expressed in the two sexes. To test whether these differences are due to sex differences in testosterone exposure, we injected female pups with testosterone propionate (TP) on the day of birth and analyzed the levels of AR and ER IR at PN1. TP-treated females have lower levels of AR and ERbeta IR than control, while there are no differences in the levels of ERalpha IR. TP treatment did not affect the number of AR and ER expressing cells. The regulation of SNR AR and ERbeta IR by testosterone may be important for the development of sex-specific functional systems involved in motor control.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ravizza T,Velísková J,Moshé SLdoi
10.1016/s0304-3940(02)01317-4keywords:
subject
Has Abstractpub_date
2003-02-20 00:00:00pages
57-61issue
1eissn
0304-3940issn
1872-7972pii
S0304394002013174journal_volume
338pub_type
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