Effects of gender and gonadal hormones on nociceptive responses to intraplantar carrageenan in the rat.

Abstract:

:The effects of gender and gonadal hormones on nociceptive responses to intraplantar carrageenan in the rat were investigated. A plantar analgesic meter was used to measure carrageenan-induced changes in paw withdrawal latency (PWL) values, and von Frey monofilaments were used to assess changes in paw withdrawal threshold (PWT) values in response to tactile-evoked (mechanical) stimuli. The data revealed that PWL values were significantly greater in gonadally-intact females than in gonadally-intact males, and this response was abolished by surgical gonadectomies. Gonadally-intact as well as gonadectomized male and female rats also exhibited significant carrageenan-induced decreases in PWT, but neither sex- nor gonadectomy-related differences were detected in the development of mechanical allodynia. These findings demonstrate that intraplantar carrageenan induces nociceptive behaviors in rats that are differentially affected by sex and gonadal hormones.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Tall JM,Crisp T

doi

10.1016/j.neulet.2003.09.081

keywords:

subject

Has Abstract

pub_date

2004-01-16 00:00:00

pages

239-41

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394003012278

journal_volume

354

pub_type

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