Abstract:
:N-Methyl-D-aspartate (NMDA)-evoked release of [3H]acetylcholine (ACh) from slices of rat brain medial septum/vertical limb of the diagonal band (ms/vdB) was examined. NMDA increased the release of tritium in a concentration-dependent manner and the specific non-competitive NMDA antagonist, MK-801, and the competitive NMDA antagonist kynurenic acid inhibited this release. Tetrodotoxin inhibited the NMDA-evoked release suggesting the [3H]ACh released arises from collaterals of the cholinergic septohippocampal neurons. Basal release of tritium was significantly increased by glycine alone and strychnine inhibited this response while having no effect on NMDA-evoked release. However, glycine, although not affecting the NMDA-evoked release, did enhance release of tritium in the presence of NMDA and blocking concentrations of Kynurenic acid. Together, these findings suggest that under the conditions of these experiments sufficient concentrations of glycine permit the full expression of NMDA-evoked modulation of [3H]ACh release, and that the predominant actions of glycine were mediated by a specific, strychnine-sensitive receptor.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Nishimura LM,Boegman RJdoi
10.1016/0304-3940(90)90465-lsubject
Has Abstractpub_date
1990-07-31 00:00:00pages
259-64issue
2-3eissn
0304-3940issn
1872-7972pii
0304-3940(90)90465-Ljournal_volume
115pub_type
杂志文章abstract::Our previous studies have shown that acupuncture attenuates morphine self-administration and sensitization behavior as well as withdrawal signs. The present study was designed to investigate the role of acupuncture in the reinstatement of morphine seeking. Male Sprague-Dawley rats weighing 270-300 g were subjected to ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.09.020
更新日期:2012-10-31 00:00:00
abstract::The present study examined perception of individual finger forces during multi-finger force production tasks. In an ipsilateral force matching paradigm, 12 healthy subjects were instructed to produce a reference force pre-determined at 30% MVC of involved fingers (varying from 1 to 4 fingers, visual feedback of total ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.09.057
更新日期:2006-12-06 00:00:00
abstract::Using an antiserum (AS) raised against dynorphin B (DYN B), we revealed immunoreactive neurons in different nuclei of the rat hypothalamus as well as a population of neurons scattered in the lateral areas of the posterior hypothalamus. This population corresponds to that previously shown to be specifically recognized ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90447-s
更新日期:1993-06-25 00:00:00
abstract::The effect of Ca2+/calmodulin-dependent protein phosphorylation on K+ channels was examined in snail neurons, using several pharmacological agents, the voltage clamp method and the pressure injection technique. H-7, a general protein kinase inhibitor, reduced the delayed outward K+ current (IKD) which was suppressed b...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90816-c
更新日期:1991-03-11 00:00:00
abstract::The distribution of neurons containing the messenger RNA encoding preprotachykinin, the precursor of the neuropeptides substance P and K, was examined in the striatum of the rat. The large majority of cells densely labelled by in situ hybridization histochemistry (using a 35S-radiolabelled RNA probe complementary of t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90241-3
更新日期:1989-01-02 00:00:00
abstract:OBJECTIVE:Numerous studies have reported P50 gating deficits in schizophrenia, though with mixed results. Moreover, few studies have explored the association between P50 gating deficits and psychopathology in Chinese patients with schizophrenia. In the present study, we investigated the P50 auditory sensory gating patt...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.06.009
更新日期:2017-07-13 00:00:00
abstract::The noradrenergic system modulates attention and arousal. Dysregulation of the noradrenergic system may be involved in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). This study intended to examine the differences in methylphenidate (MPH) treatment response and pre- and post-treatment cerebral ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.02.079
更新日期:2012-04-18 00:00:00
abstract::This study investigated the effects of ketamine on fluoxetine-induced antidepressant behavior using the forced swimming test (FST) in mice. In order to understand the possible role of N-methyl-d-aspartate (NMDA) neurotransmission in the antidepressant effect of fluoxetine, different groups of mice (n=10) were administ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2014.01.015
更新日期:2014-04-30 00:00:00
abstract::Hearing impairment affects 1 in 500 newborns worldwide and nearly one out of three people over the age of 65 (WHO, 2019). Hereditary hearing loss is the most common type of congenital deafness; genetic factors also affect deafness susceptibility. Gene therapies may preserve or restore natural sound perception, and hav...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2019.134326
更新日期:2019-09-14 00:00:00
abstract::Evidence, based on voltage-clamp and current-clamp recording, is presented for endogenous receptors for vasoactive intestinal polypeptide (VIP) on the cell membrane of the Xenopus oocyte. At normal resting potential a hyperpolarisation is produced by VIP, associated with an increase in K+ conductance. The response is ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90221-7
更新日期:1987-12-16 00:00:00
abstract::The effect of intracerebroventricular (i.c.v.) injection of brain natriuretic peptide (BNP), a novel peptide purified from the porcine brain, on arginine vasopressin (AVP) secretion was studied in conscious, unrestrained rats and was compared with that of atrial natriuretic polypeptide (ANP). I.c.v. administration of ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90661-1
更新日期:1988-12-19 00:00:00
abstract::In CA3 pyramidal neurons of guinea pig hippocampal slices an outward current activated by the GABAB agonist, baclofen (0.3 microM, Ibac) was reduced by low concentrations of carbachol (Cch, 0.1-0.3 microM). The effect of Cch desensitized suggesting that the receptor subtype involved in this muscarinic effect of Cch wa...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90673-3
更新日期:1989-05-22 00:00:00
abstract::Tacrine (1,2,3,4-tetrahydro-9-acridinamine) inhibited binding of [3H]flunitrazepam to benzodiazepine receptors of guinea pig hippocampus with an inhibition constant of 46 microM at 2 degrees C and 37 degrees C. gamma-Aminobutyric acid (GABA) decreased the affinity of tacrine for the receptor, suggesting that tacrine m...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90473-7
更新日期:1991-08-19 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.04.064
更新日期:2011-05-06 00:00:00
abstract::The present study has described and quantitated the distribution of mu-opioid receptors in the nucleus raphe magnus (NRM) and nucleus gigantocellularis (NGC), using in vitro autoradiography. Moderately dense binding of a mu-enkephalin analog, DAGO, was observed in the NRM and adjacent parts of the NGC. DAGO binding de...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90218-2
更新日期:1988-06-07 00:00:00
abstract::The goat milk contains conjugated linoleic acid (CLA), which can influence physical growth and brain development. This study investigated the impact of a diet containing goat milk fat (GMF) on physical parameters of gestating (G) and/or lactating (L) rat dams, and their progeny's physical growth, and anxiety behavior....
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.07.028
更新日期:2013-09-27 00:00:00
abstract::The survival of identified retinal ganglion cells (RGGs) in vitro increased when they were plated over subcultured monolayers of astrocytes. Immunofluorescence labelling of these monolayers showed that over 85% of the cells were glial fibrillary acidic protein (GFAP) positive and consisted of large, flat immature astr...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(85)90512-9
更新日期:1985-06-24 00:00:00
abstract::Hippocampal choline acetyltransferase was reduced by 89% in rats two weeks after electrolytic lesion of the septum. The hippocampal concentrations of somatostatin (SOM)-14, SOM-28 and high-molecular-weight SOM were unaltered, suggesting that the activity of hippocampal SOM neurones is not influenced by cholinergic aff...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90363-0
更新日期:1986-01-30 00:00:00
abstract::Repeated stress triggers a wide range of adaptive changes in the central nervous system including the elevation of serotonin (5-HT) metabolism and an increased susceptibility to affective disorders. To begin to examine whether these changes are mediated by alterations in gene expression for tryptophan hydroxylase (TPH...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00340-7
更新日期:1999-06-04 00:00:00
abstract::Loss of balance and increased fall risk is a common problem associated with aging. Changes in vestibular function occur with aging but the contribution of reduced vestibular otolith function to fall risk remains unknown. We examined a population of 151 healthy individuals (aged 21-93) for both balance (sway measures) ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.08.057
更新日期:2009-11-06 00:00:00
abstract::In pentobarbital anesthetized rats, unilateral microinjection (500 ng) of the selective perikaryal excitotoxin, kainic acid, into the nucleus ambiguus promoted a significant suppression of arterial pressure, heart rate and cardiac contractility. The degree of such cardiovascular depression followed the order of heart ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90386-0
更新日期:1984-06-01 00:00:00
abstract::In decerebrated rabbits, reflexes were evoked in medial gastrocnemius motoneurones by mechanical stimulation of the heel, using four pinch strengths from 183 (innocuous) to 4577 (noxious) mN. The alpha(2)-adrenoceptor antagonist idazoxan (1-156 microg intrathecal (i.th.) significantly increased responses to pinch stre...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02005-5
更新日期:2001-08-10 00:00:00
abstract::Acute stress can provoke apoptosis of the retina cells, and up-regulation of calcitonin gene related peptide (CGRP) in retina. However the role of CGRP in the pathology of the stress induced apoptosis of the retina cells is still elusive. The aim of this study was to investigate the endogenous of CGRP on retinal cell ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.06.049
更新日期:2011-08-26 00:00:00
abstract::We assessed whether tolerance develops to the antinociceptive effect of intrathecal (i.t.) orphanin FQ, the endogenous ligand of the orphan opioid-like receptor, and whether there is a cross-tolerance between the antinociceptive effect of i.t. orphanin FQ and the mu opioid receptor agonist morphine. Orphanin FQ admini...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)13401-2
更新日期:1997-02-14 00:00:00
abstract::Recent studies suggested that statins have anti-inflammatory effects beyond their lipid-lowering properties. In the present study, we sought to investigate whether rosuvastatin could alleviate morphine tolerance by attenuating the glia mediated neuroinflammation in the spinal cord. Using a rat model of L5 spinal nerve...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2014.11.003
更新日期:2015-01-01 00:00:00
abstract::Bipolar disorder (BD) is a debilitating mental disorder with complex clinical manifestations and low diagnostic accuracy. Depressive episodes are most common in the course of BD with high comorbidity and suicide rates, which present greater clinical challenges than mania and hypomania episodes. However, there are no o...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2020.135515
更新日期:2021-01-18 00:00:00
abstract::Cerebral perfusion is important in older adults as it is linked to cognitive declines. Physical activity can improve blood flow in the body but little is known about the relationship between physical activity and cerebral perfusion in older adults. In particular, no study has investigated the relation between strength...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.12.011
更新日期:2014-02-07 00:00:00
abstract::Following the iontophoretic deposition of Phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral ventrolateral medulla (RVL), two-color immunoperoxidase staining was employed to demonstrate contiguity between PHA-L-immunoreactive (PHA-LI) varicose fibers and boutons and brainstem monoaminergic cells. Black-staine...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90201-4
更新日期:1991-01-14 00:00:00
abstract::Recently, our group described the ether-à-go-go1(Eag1) voltage-gated potassium (K(+)) channel (Kv10.1) expression in the dopaminergic cells indicating that these channels are part of the diversified group of ion channels related to dopaminergic neurons function. The increase of dopamine neurotransmission induces a red...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.11.026
更新日期:2014-01-24 00:00:00
abstract::The opioid peptide dynorphin A(1-8) (1 micron) increased acetylcholine release from the Torpedo electric organ by approximately twofold. This effect was reversed by the opiate antagonist naloxone. The effect of Dyn A(1-8) on acetylcholine release was found to vary in magnitude with the seasons of the year, with maxima...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90036-s
更新日期:1991-04-29 00:00:00