Vasoactive intestinal peptide (VIP) induces a K+ current in the Xenopus oocyte membrane.

Abstract:

:Evidence, based on voltage-clamp and current-clamp recording, is presented for endogenous receptors for vasoactive intestinal polypeptide (VIP) on the cell membrane of the Xenopus oocyte. At normal resting potential a hyperpolarisation is produced by VIP, associated with an increase in K+ conductance. The response is dose-dependent, with a threshold near 10(-9)M VIP. The effect is potentiated by forskolin. Of several other types of neuropeptide tested, only avian pancreatic polypeptide gives a response: this is similar to that of VIP, but this peptide can also potentiate the response to VIP.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Reale V,Ashford ML,Barnard EA

doi

10.1016/0304-3940(87)90221-7

subject

Has Abstract

pub_date

1987-12-16 00:00:00

pages

89-94

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(87)90221-7

journal_volume

83

pub_type

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