Abstract:
:Evidence, based on voltage-clamp and current-clamp recording, is presented for endogenous receptors for vasoactive intestinal polypeptide (VIP) on the cell membrane of the Xenopus oocyte. At normal resting potential a hyperpolarisation is produced by VIP, associated with an increase in K+ conductance. The response is dose-dependent, with a threshold near 10(-9)M VIP. The effect is potentiated by forskolin. Of several other types of neuropeptide tested, only avian pancreatic polypeptide gives a response: this is similar to that of VIP, but this peptide can also potentiate the response to VIP.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Reale V,Ashford ML,Barnard EAdoi
10.1016/0304-3940(87)90221-7subject
Has Abstractpub_date
1987-12-16 00:00:00pages
89-94issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(87)90221-7journal_volume
83pub_type
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journal_title:Neuroscience letters
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pub_type: 杂志文章
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