Abstract:
:Substance P (SP) plays an important role in sensitization of spinal cord neurons. In this study, we investigated SP-induced calcium activities in cultured rat spinal cord neurons with confocal laser scanning microscopy. Our results showed that SP increased [Ca(2+)](i) by calcium entry rather than release from intracellular calcium stores. Neomycin (100 microM), an antagonist of phosphatidylinositol 4,5-bisphosphate (PIP(2)), blocked SP-induced calcium entry. Ca(2+)-free medium induced capacitative entry, which was significantly potentiated by SP. As activation of SP receptor (NK-1) leads to production of inositol 1,4,5-trisphosphate (IP(3)) by PIP(2) turnover, the results indicates that SP-induced calcium entry and SP-potentiated capacitative calcium entry might be mediated or regulated by IP(3)/diacylglycerol (DG) pathway.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Zhou ZS,Shu YS,Zhao ZQdoi
10.1016/s0304-3940(00)01135-6keywords:
subject
Has Abstractpub_date
2000-06-16 00:00:00pages
57-60issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(00)01135-6journal_volume
287pub_type
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