Abstract:
:Our previous work has established that adenosine is toxic to chick embryonic sympathetic neurons and kills freshly plated neurons by a process of apoptosis. Although the exact mechanism remains unknown, we found that phosphorylation of adenosine was essential to the toxicity. Using markers for RNA ([3H]uridine) and protein ([35S]methionine) synthesis we demonstrate here that in freshly plated sympathetic neurons adenosine inhibits RNA and protein synthesis by about 50%. The inhibitory effects of adenosine on RNA and protein synthesis, and increased ATP synthesis were blocked by adenosine kinase inhibitor, suggesting that phosphorylated products are responsible for inhibition of RNA and protein synthesis and cell death. Adenosine-induced inhibition of RNA and protein synthesis in neuronal cells provides a new role for adenosine in the regulation of cell function.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kulkarni JS,Przywara DA,Wakade TD,Wakade ARdoi
10.1016/s0304-3940(98)00369-3subject
Has Abstractpub_date
1998-06-05 00:00:00pages
187-90issue
3eissn
0304-3940issn
1872-7972pii
S0304394098003693journal_volume
248pub_type
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