Abstract:
:Because reelin and prestin genes are located close together on mouse chromosome 5, reelin homozygous mutant mice were compared with littermate controls. Experiments were designed to determine if the deletion in the reeler mouse affects the coding and/or regulatory regions for the expression of prestin, the outer hair cell motor protein. Data indicate that homozygous reeler mice express prestin mRNA and protein, as do controls. Cochlear sensitivity, determined using compound action potential thresholds measured at the round window, is also similar. Hence, threshold shifts previously observed in auditory brainstem responses are not due to cochlear problems. Because prestin expression is not affected in reeler mice, prestin's coding region, as well as any regulatory elements, is predicted to lie in the 17 kb that separate prestin's exon 1 from the end of the deletion.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Zheng J,Richter CP,Cheatham MAdoi
10.1016/s0304-3940(03)00597-4keywords:
subject
Has Abstractpub_date
2003-08-14 00:00:00pages
13-6issue
1eissn
0304-3940issn
1872-7972pii
S0304394003005974journal_volume
347pub_type
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