Suppression of postsynaptic density protein 95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N-methyl-D-aspartate receptors and interactions of Src and Fyn with NR2A after transient brain ischemia in rat hippocampus.

abstract：:Sinomenine, one of the alkaloids extracted from roots or stems of Sinomenium acutum, is documented to show antinociceptive action but the action mechanism is still unclear. The present study was aimed to investigate the effect of sinomenine on opioid mu-receptor (OMR). In Chinese Hamster Ovary (CHO) cell transfected w...

journal_title：Neuroscience letters

authors： Wang MH,Chang CK,Cheng JH,Wu HT,Li YX,Cheng JT

更新日期：2008-10-10 00:00:00

abstract：:Normal aging is associated with chronic oxidative stress. In the basal ganglia, oxidative stress may contribute to the increased risk of Parkinson's disease in the elderly. Neurons are thought to actively utilize compensatory defense mechanisms, such as heat shock proteins (HSPs), to protect from persisting stress. De...

journal_title：Neuroscience letters

authors： Gupte AA,Morris JK,Zhang H,Bomhoff GL,Geiger PC,Stanford JA

更新日期：2010-03-19 00:00:00

abstract：:These experiments show that a synaptic response, namely the late inhibitory postsynaptic potential (IPSP) of hippocampal CA3 neurons of rats, is blocked by pertussis toxin, an inactivator of several GTP-binding proteins (G-proteins) excluding the G-protein that stimulates adenylyl cyclase. This blockage occurred witho...

journal_title：Neuroscience letters

authors： Thalmann RH

更新日期：1987-11-10 00:00:00

abstract：:This experiment examined the hypothesis that aging reduces the coupling between system components, resulting in a loss of complexity in behavior. Young (18-23 years), old (60-65 years), and older old (70-75 years) subjects performed rhythmical movement and postural tasks with the index finger. Irregularity of the acce...

journal_title：Neuroscience letters

authors： Hong SL,James EG,Newell KM

更新日期：2008-03-12 00:00:00

abstract：:Autosomal-dominant familial amyotrophic lateral sclerosis (FALS) is associated with mutation in the gene that encodes Cu/Zn superoxide dismutase (SOD1). We identified a novel missense mutation of SOD-1 (Cys6Gly) in exon 1 in a Japanese woman and her family. The illness showed rapid progression similarly to the FALS wi...

journal_title：Neuroscience letters

authors： Kohno S,Takahashi Y,Miyajima H,Serizawa M,Mizoguchi K

更新日期：1999-12-03 00:00:00

abstract：:Genetic polymorphisms in chemokine receptor and their natural ligand genes have been shown to modify the disease progression of Alzheimer's disease (AD). Human macrophage inflammatory protein-1 alpha (MIP-1alpha) is a chemotactic cytokine which plays a considerable role in AD pathogenesis, but its genetic contribution...

journal_title：Neuroscience letters

authors： Li K,Dai D,Yao L,Gu X,Luan K,Tian W,Zhao Y,Wang B

更新日期：2008-03-12 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor that causes hypoperfusion of the neurosensory retina. We investigated immunohistochemically the expression of the receptors for ET-1, ET(A) and ET(B), in control and locally detached retinas of the pig. Immunoreactivity for ET(A) was expressed in the innermost retinal la...

journal_title：Neuroscience letters

authors： Iandiev I,Uhlmann S,Pietsch UC,Biedermann B,Reichenbach A,Wiedemann P,Bringmann A

更新日期：2005-08-12 00:00:00

abstract：:Decreased dopamine (DA) release in the hippocampus may be caused by dysfunctional mastication, although the mechanisms involved remain unclear. The present study examined the effects of soft- and hard-food diets on oxidative stress in the brain, and the relationship between these effects and hippocampal DA levels. The...

journal_title：Neuroscience letters

authors： Yoshino F,Yoshida A,Hori N,Ono Y,Kimoto K,Onozuka M,Lee MC

更新日期：2012-02-02 00:00:00

abstract：:The effects of classical fear conditioning in different regions of the limbic system were analysed using cytochrome oxidase (CO) histochemistry. Wistar rats were submitted to different conditions. Rats in the group Paired received tone-shock pairing, to elicit conditioned suppression of lever pressing (i.e., tone will...

journal_title：Neuroscience letters

authors： Conejo NM,López M,Cantora R,González-Pardo H,López L,Begega A,Vallejo G,Arias JL

更新日期：2005-01-10 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis and blood vessel function. Recent evidence indicates that VEGF facilitates memory and learning through stimulating angiogenesis and neurogenesis in the rat hippocampal dendate gyrus. Abnormal regulation of VEGF expression has been reported ...

journal_title：Neuroscience letters

authors： Mateo I,Llorca J,Infante J,Rodríguez-Rodríguez E,Sánchez-Quintana C,Sánchez-Juan P,Berciano J,Combarros O

更新日期：2006-06-19 00:00:00

abstract：:Divalent metals such as cobalt are frequently used by neurophysiologists to prevent synaptic transmission, because they are thought to selectively block presynaptic calcium conductance. Recording intracellularly from hippocampal CA3 pyramidal cells we show that Co2+ (2 mM) is not specific in this action but also dimin...

journal_title：Neuroscience letters

authors： Gerber U,Gähwiler BH

更新日期：1991-12-16 00:00:00

abstract：:The factors determining the large variation seen in human corpus callosum (CC) morphology are as yet unknown. In this study heritability of CC size was assessed by comparing the concordance of CC midsagittal area in 14 monozygotic and 12 dizygotic twin pairs with a mean age of 27 years, using magnetic resonance imagin...

journal_title：Neuroscience letters

authors： Scamvougeras A,Kigar DL,Jones D,Weinberger DR,Witelson SF

更新日期：2003-02-27 00:00:00

abstract：:Selective loss of central dopaminergic neurons in vitro and in vivo can be initiated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) through its metabolite phenylpyridium ion (MPP+). Such MPTP-mediated cytotoxicity can be blocked by (-)-Deprenyl, a monoamine oxidase (MAO)-B inhibitor, but the exact mechanisms o...

journal_title：Neuroscience letters

authors： Le W,Jankovic J,Xie W,Kong R,Appel SH

更新日期：1997-03-21 00:00:00

abstract：:The cellular localisation of benzodiazepine receptors was studied. Kainic acid induced neuronal lesions (2 x 0.25-2 x 2 micrograms; 2-26 days in rat cerebellum decreased specific binding of [3H]flunitrazepam down to 35% of controls. Specific binding of [3H]flunitrazepam was also decreased (to 80% of controls) in the c...

journal_title：Neuroscience letters

authors： Braestrup C,Nielsen M,Biggio G,Squires RF

更新日期：1979-08-01 00:00:00

abstract：:Satellite glial cells (SGCs) surround the neurons in sympathetic ganglia and are believed to make important contributions to the function of the ganglia under normal and pathological conditions. It has been proposed that SGCs communicate chemically with the neurons, but little is known about their pharmacological prop...

journal_title：Neuroscience letters

authors： Feldman-Goriachnik R,Wu B,Hanani M

更新日期：2018-04-03 00:00:00

abstract：PURPOSE:To investigate the brain protective effects of fingolimod on inflammatory response of SAH mice. METHODS:We utilized an endovascular mouse perforation model of SAH. Mice were divided into three groups: sham group, SAH group and SAH + Fingolimod group. Mice received either saline or fingolimod (1 mg/kg) intraper...

journal_title：Neuroscience letters

authors： Wang Y,Zhou S,Han Z,Yin D,Luo Y,Tian Y,Wang Z,Zhang J

更新日期：2020-09-25 00:00:00

abstract：:In the present study we have used slice cultures of hippocampus and in situ hybridization techniques in order to study the ability of hippocampal neurons to synthesize CCK mRNA in the absence of extrinsic afferents. Our results show that very similar types of hippocampal neurons express CCK mRNA in culture as in situ....

journal_title：Neuroscience letters

authors： Straube A,Bender R,Otten U,Frotscher M

更新日期：1994-05-19 00:00:00

abstract：:Using an animal model of temporal lobe epilepsy, the kainic acid lesioned rat hippocampus, we have evaluated the possibility of modulating glutamate N-methyl-D-aspartate (NMDA) receptor-dependent evoked epileptiform activity through the manipulation of NMDA receptor redox sites. Epileptiform activity was recorded extr...

journal_title：Neuroscience letters

authors： Quesada O,Hirsch J,Ben-Ari Y,Bernard C

更新日期：1996-07-19 00:00:00

abstract：:Following ventral root injury-filling with horseradish peroxidase at sacral spinal levels S1, S2, and S3, small fascicles of axons can be observed to enter the ventral portion of lamina I and arborize primarily in the dorsolateral region just medial to the tract of Lissauer (TL). Some axons enter the TL and turn in a ...

journal_title：Neuroscience letters

authors： Beattie MS,Bresnahan JC,Mawe GM,Finn S

更新日期：1987-04-23 00:00:00

abstract：:Rhythms of plasma melatonin levels were determined in lizards (Tiliqua rugosa) subjected to a 12 h photocycle (12 h light: 12 h dark) at constant 33 degrees C, and at 7 different thermoperiods (33 degrees C thermophase and 15 degrees C cryophase) whose thermophase duration ranged from 1.5 to 21 h. The melatonin secret...

journal_title：Neuroscience letters

authors： Firth BT,Kennaway DJ,Belan I

更新日期：1991-01-02 00:00:00

abstract：:By a double-labeling method combining the retrograde tracing of horseradish peroxidase and the immunocytochemical technique, serotonin-, substance P- or leucine-enkephalin-like immunoreactive neurons in the midbrain periaqueductal gray (PAG) and the nucleus raphe dorsalis (DR) of the rat were found to send projection ...

journal_title：Neuroscience letters

authors： Li YQ,Jia HG,Rao ZR,Shi JW

更新日期：1990-11-27 00:00:00

abstract：:Temperature effects on ocular serotonin N-acetyltransferase (NAT) kinetics characteristics from Rana perezi have been studied with respect to tryptamine and serotonin as substrates. Monoamine oxidase (MAO) activity does not interfere in NAT assay at acceptoramine concentrations used in NAT kinetics characterization fr...

journal_title：Neuroscience letters

authors： Alonso-Gómez AL,Alonso-Bedate M,Delgado MJ

更新日期：1993-05-28 00:00:00

abstract：:Fe65 is a brain enriched multi domain adaptor protein involved in diverse cellular functions. One of its binding partners is the amyloid-β (Aβ) precursor protein (APP), which after sequential proteolytic processing by secretases gives rise to the Alzheimer's Aβ peptide. Fe65 binds to the APP intracellular domain (AICD...

journal_title：Neuroscience letters

authors： Koistinen NA,Bacanu S,Iverfeldt K

更新日期：2016-02-02 00:00:00

abstract：:Variation in AKT1 has been associated with schizophrenia, bipolar disease and type II diabetes. The aim of the present study was to investigate the potential role of variability within AKT1 as a risk factor for Parkinson's disease (PD). We performed a case-control association analysis of AKT1 in a Greek cohort of PD u...

journal_title：Neuroscience letters

authors： Xiromerisiou G,Hadjigeorgiou GM,Papadimitriou A,Katsarogiannis E,Gourbali V,Singleton AB

更新日期：2008-05-09 00:00:00

abstract：:We have reported that an arousal response accompanied by yawning behavior can be evoked by electrical and chemical stimulation of the hypothalamic paraventricular nucleus (PVN) in rats, although the mechanism responsible for the arousal response accompanied by yawning evoked by PVN stimulation is still unknown. In the...

journal_title：Neuroscience letters

authors： Kita I,Kubota N,Yanagita S,Motoki C

更新日期：2008-03-15 00:00:00

abstract：:Cultured rat pheochromocytoma cells, PC-12, were found to contain renin-like activity. The activity which was inhibited by monospecific antibodies to rat renal renin showed a pH optimum between 6 and 7, indicating that it was a specific renin. The cells also contained angiotensin I and angiotensin I converting enzyme....

journal_title：Neuroscience letters

authors： Okamura T,Clemens DL,Inagami T

更新日期：1984-05-04 00:00:00

abstract：:We had previously reported that small gap neurorrhaphy by scissoring and sleeve-jointing epineurium could enhance the rate and quality of peripheral nerve regeneration. To date, local implantation and systemic delivery of bone marrow mesenchymal stem cells (BMSCs) have been routinely used in nerve tissue engineering, ...

journal_title：Neuroscience letters

authors： Wang P,Zhang Y,Zhao J,Jiang B

更新日期：2015-01-12 00:00:00

abstract：:The aim of the present study was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-opioid receptor in the mouse pons/medulla and spinal cord, monitor...

journal_title：Neuroscience letters

authors： Narita M,Mizoguchi H,Khotib J,Suzuki M,Ozaki S,Yajima Y,Narita M,Tseng LF,Suzuki T

更新日期：2002-10-04 00:00:00

abstract：:Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in the synthesis of brain serotonin (5-HT). In a previous report, a single nucleotide polymorphism in mTph2 (C1473G) reduced 5-HT synthesis by 55%. Mouse strains expressing the 1473C allele, such as C57Bl/6, have higher 5-HT synthesis rates than strains ...

journal_title：Neuroscience letters

authors： Siesser WB,Zhang X,Jacobsen JP,Sotnikova TD,Gainetdinov RR,Caron MG

更新日期：2010-08-30 00:00:00

abstract：:Because of their limited regenerative potential, cochlear hair cell loss is one of the major causes of permanent hearing loss in mammals. However, recent studies have shown that postnatal cochlear epithelia retain the progenitor cells that form otospheres. Otospheres are capable of self-renewing and differentiating in...

journal_title：Neuroscience letters

authors： Lou XX,Nakagawa T,Ohnishi H,Nishimura K,Ito J

更新日期：2013-02-08 00:00:00