Abstract:
:These experiments show that a synaptic response, namely the late inhibitory postsynaptic potential (IPSP) of hippocampal CA3 neurons of rats, is blocked by pertussis toxin, an inactivator of several GTP-binding proteins (G-proteins) excluding the G-protein that stimulates adenylyl cyclase. This blockage occurred without a similar effect upon either the mossy fiber-evoked EPSP or the early (GABAa-mediated) IPSP. The toxin also blocked the response to baclofen, an agonist for a putative receptor (GABAb) mediating the late IPSP, but did not affect the response to THIP, an agonist for the receptor (GABAa) mediating the early IPSP. It is proposed that a pertussis toxin-sensitive G-protein controls the conductance of the late IPSP.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Thalmann RHdoi
10.1016/0304-3940(87)90168-6subject
Has Abstractpub_date
1987-11-10 00:00:00pages
41-6issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(87)90168-6journal_volume
82pub_type
杂志文章abstract:OBJECTIVES:Suicide attempt in schizophrenia is an important clinical issue. We performed a genome-wide association study to identify genetic markers, which increase the risk for suicide attempt in schizophrenia. METHODS:Suicide attempt lifetime was assessed in 121 schizophrenia patients and defined by the means of the...
journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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更新日期:2012-10-31 00:00:00
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