Abstract:
:This study investigates whether potassium ion (K+) channels are involved in the nitric oxide (NO)-induced relaxation in segments of the isolated rat basilar artery, mounted onto a wire myograph. A high extracellular K+ concentration partly inhibited the relaxant effects of the NO donors DEA/NO and SIN-1 (3-morpholino-sydnonimine). Whereas single applications of the K+ channel inhibitors tetraethyl-ammonium (10(-3) M), glibenclamide (10(-6) M), 4-aminopyridine (10(-3) M), or BaCl(2) (5 x 10(-5) M) did not affect the responses to DEA/NO, a combination of these inhibitors reduced the effects of DEA/NO. These data suggest, that the relaxant effects of NO donors are partly mediated via activation of K+channels. Different K+ channel types seem to be involved that function in a redundant manner and compensate for each other.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hempelmann RG,Seebeck J,Kruse ML,Ziegler A,Mehdorn HMdoi
10.1016/s0304-3940(01)02225-xkeywords:
subject
Has Abstractpub_date
2001-11-02 00:00:00pages
21-4issue
1-2eissn
0304-3940issn
1872-7972pii
S030439400102225Xjournal_volume
313pub_type
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