Role of potassium channels in the relaxation induced by the nitric oxide (NO) donor DEA/NO in the isolated rat basilar artery.

Abstract:

:This study investigates whether potassium ion (K+) channels are involved in the nitric oxide (NO)-induced relaxation in segments of the isolated rat basilar artery, mounted onto a wire myograph. A high extracellular K+ concentration partly inhibited the relaxant effects of the NO donors DEA/NO and SIN-1 (3-morpholino-sydnonimine). Whereas single applications of the K+ channel inhibitors tetraethyl-ammonium (10(-3) M), glibenclamide (10(-6) M), 4-aminopyridine (10(-3) M), or BaCl(2) (5 x 10(-5) M) did not affect the responses to DEA/NO, a combination of these inhibitors reduced the effects of DEA/NO. These data suggest, that the relaxant effects of NO donors are partly mediated via activation of K+channels. Different K+ channel types seem to be involved that function in a redundant manner and compensate for each other.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Hempelmann RG,Seebeck J,Kruse ML,Ziegler A,Mehdorn HM

doi

10.1016/s0304-3940(01)02225-x

keywords:

subject

Has Abstract

pub_date

2001-11-02 00:00:00

pages

21-4

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

S030439400102225X

journal_volume

313

pub_type

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