当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice.

Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice.

Abstract：

:Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in the synthesis of brain serotonin (5-HT). In a previous report, a single nucleotide polymorphism in mTph2 (C1473G) reduced 5-HT synthesis by 55%. Mouse strains expressing the 1473C allele, such as C57Bl/6, have higher 5-HT synthesis rates than strains expressing the 1473G allele, such as BALB/c. Many studies have attributed strain differences to Tph2 genotype without ruling out the potential role of alterations in other genes. To test the role of the C1473G polymorphism in strain differences, we generated C57Bl/6 and BALB/c mice congenic for the Tph2 locus. We found that the 1473G allele reduced 5-HT synthesis in C57Bl/6 mice but had no effect on 5-HT tissue content except for a slight reduction (15%) in the frontal cortex. In BALB/c mice, the 1473C allele increased 5-HT synthesis but again did not affect 5-HT tissue content. At the same time, 5-hydroxyindoleacetic acid (5-HIAA) was significantly elevated in BALB/c congenic mice. In C57Bl/6 mice, there was no effect of genotype on 5-HIAA levels. BALB/c mice had lower expression of monoamine oxidase A and B than C57Bl/6 mice, but there was no effect of Tph2 genotype. On the tail suspension test, escitalopram treatment reduced immobility regardless of genotype. These data demonstrate that the C1473G polymorphism determines differences in 5-HT synthesis rates among strains but only minimally affects 5-HT tissue levels.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Siesser WB,Zhang X,Jacobsen JP,Sotnikova TD,Gainetdinov RR,Caron MG

doi

10.1016/j.neulet.2010.06.035

subject

Has Abstract

pub_date

2010-08-30 00:00:00

pages

6-11

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(10)00783-4

journal_volume

481

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Electroretinograms remain normal in mice lacking a synapse associated protein.

    abstract：:Integrin-associated protein (IAP) is normally localized to the synapse rich plexiform layers of the mammalian retina. In other neuronal systems, IAP and its ligand, P84, have been implicated in synaptic function. Previously, an abnormal distribution of P84 was noted in the IAP-null retina. To examine the potential rol...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)01743-2

    authors： Ball SL,Lindberg FP,Lagenaur CF,Peachey NS

    更新日期：2001-02-02 00:00:00

  • Comparison of glycine- and GABA-evoked currents in two types of neurons isolated from the rat striatum.

    abstract：:Strychnine-sensitive glycine-activated currents and gamma-aminobutyric acid (GABA)-activated currents were compared in two types of neurons acutely isolated from striatal slices by vibrodissociation: large cells, presumably cholinergic giant aspiny neurons (GAN) and medium sized cells, presumed medium spiny neurons (M...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(98)00072-x

    authors： Sergeeva OA

    更新日期：1998-02-27 00:00:00

  • Effects of repeated dizocilpine treatment on glutamatergic activity in the prefrontal cortex in an animal model of schizophrenia: An in vivo proton magnetic resonance spectroscopy study at 9.4T.

    abstract：:Repeated exposure to dizocilpine (MK-801) can be used as a model of schizophrenia that incorporates disease progression. Proton magnetic resonance spectroscopy (1H MRS) has been widely used to investigate schizophrenia-related alterations in glutamate (Glu). The purpose of this study was to investigate metabolic alter...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2016.11.053

    authors： Yoo CH,Song KH,Lim SI,Lee DW,Woo DC,Choe BY

    更新日期：2017-01-10 00:00:00

  • Neuroprotective effects of Buyang Huanwu Decoction on neuronal injury in hippocampus after transient forebrain ischemia in rats.

    abstract：:Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine, has been developed as a drug to be used for treatment of stroke for hundreds of years. However, the underlying mechanisms remain unknown. In the present study, the effects of BYHWD on delayed neuronal death of hippocampus after transient forebrain ischem...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(03)00522-6

    authors： Li XM,Bai XC,Qin LN,Huang H,Xiao ZJ,Gao TM

    更新日期：2003-07-31 00:00:00

  • 2-Chloroadenosine decreases long-term potentiation in the hippocampal CA1 area of the rat.

    abstract：:The effect of the adenosine (ADO) analogue 2-chloroadenosine (CADO) on frequency-induced long-term potentiation (LTP) of the responses evoked by stimulation of the Schaffer fibres and recorded in CA1 area was studied in hippocampal slices of the rat. CADP significantly decreased LTP of the population spikes (PS) (EC50...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(90)90260-g

    authors： de Mendonça A,Ribeiro JA

    更新日期：1990-10-02 00:00:00

  • Genetic polymorphism in the persyn (gamma-synuclein) gene and the risk of Alzheimer's disease.

    abstract：:Alzheimer's disease (AD) is a complex disease with the possible involvement of several genes. Genetic studies on sporadic late-onset AD have determined APOE*4 to be the major risk factor. Members of the synuclein gene family are potential candidates for the risk of AD. The persyn gene (gamma-synuclein) has recently be...

    journal_title：Neuroscience letters

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0304-3940(99)00025-7

    authors： Luedecking EK,Ganguli M,DeKosky ST,Kamboh MI

    更新日期：1999-02-19 00:00:00

  • Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus.

    abstract：:Hyperforin is the main antidepressant component of hypericum perforatum (St. John's Wort). Using the push-pull superfusion technique we tested whether hyperforin influences extracellular concentrations of neurotransmitters in the rat locus coeruleus. Hyperforin (10 mg/kg, i.p.) not only enhanced the extracellular leve...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(99)00087-7

    authors： Kaehler ST,Sinner C,Chatterjee SS,Philippu A

    更新日期：1999-03-12 00:00:00

  • Amyloid-beta production in aged guinea pigs: atropine-induced enhancement is reversed by naloxone.

    abstract：:Advanced age, cholinergic deficit, and elevated brain levels of enkephalin are associated with sporadic Alzheimer's disease. The influence of these factors on production of amyloidogenic peptides (Abeta) is uncertain. In the present experiments, the levels of 40/42 amino acid-residue Abeta were measured in the brain c...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.06.010

    authors： Ionov ID,Pushinskaya II

    更新日期：2010-08-09 00:00:00

  • Haptic information provided by the "anchor system" reduces trunk sway acceleration in the frontal plane during tandem walking in older adults.

    abstract：:This study assessed whether the use of an "anchor system" benefited older adults who performed a tandem walking task. Additionally, we tested the effects of practice with the anchor system during walking on trunk stability, in the frontal plane, of older adults. Forty-four older adults were randomly assigned to three ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2015.10.004

    authors： Costa AA,Manciopi PA,Mauerberg-deCastro E,Moraes R

    更新日期：2015-11-16 00:00:00

  • Stressful experience has opposite effects on dendritic spines in the hippocampus of cycling versus masculinized females.

    abstract：:Stress increases associative learning and the density of dendritic spines in the hippocampus of male rats. In contrast, exposure to the same stressor impairs associative learning and reduces spine density in females. These effects in females are most evident when they are in the proestrus phase of the estrous cycle. A...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.10.051

    authors： Dalla C,Whetstone AS,Hodes GE,Shors TJ

    更新日期：2009-01-02 00:00:00

  • The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice.

    abstract：:Flupirtine is a centrally acting nonopioid analgesic with muscle-relaxant properties. Flupirtine has been found to activate inwardly rectifying potassium conductances and hence to indirectly inhibit the activation of NMDA receptors. NMDA receptor activation is crucial for the induction of long-term potentiation (LTP) ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2004.08.014

    authors： Azad SC,Eder M,Simon W,Hapfelmeier G,Dodt HU,Zieglgänsberger W,Rammes G

    更新日期：2004-11-11 00:00:00

  • Carbachol phase shifts circadian activity rhythms in ovariectomized rats.

    abstract：:Ovariectomy in the rat abolishes alpha-bungarotoxin (alpha-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically o...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90541-0

    authors： Mistlberger RE,Rusak B

    更新日期：1986-12-23 00:00:00

  • Chloride homeostasis differentially affects GABA(A) receptor- and glycine receptor-mediated effects on spontaneous circuit activity in hippocampal cell culture.

    abstract：:The potassium-chloride cotransporter 2 (KCC2)-dependent intracellular chloride level determines whether neurons respond to GABA and/or glycine by depolarization or hyperpolarization. However, still unknown is the role of KCC2-dependent chloride homeostasis in regulating the spontaneous activity of neuronal circuits vi...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.06.064

    authors： Wang W,Xu TL

    更新日期：2006-10-02 00:00:00

  • Aripiprazole increases dopamine but not noradrenaline and serotonin levels in the mouse prefrontal cortex.

    abstract：:Aripiprazole, a novel atypical antipsychotic drug, can significantly increase dopamine (DA) levels in the prefrontal cortex of rats, but only at low doses below 1mg/kg. The aim of the present work was to test the effect of aripiprazole (0, 0.1, 0.3, 3 and 30 mg/kg, i.p.) on extracellular levels of monoamines in the pr...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.06.035

    authors： Zocchi A,Fabbri D,Heidbreder CA

    更新日期：2005-10-28 00:00:00

  • Increased phosphorylated-mu-opioid receptor immunoreactivity in the mouse spinal cord following sciatic nerve ligation.

    abstract：:The present study was designed to determine whether a state of neuropathic pain induced by sciatic nerve ligation could alter phosphorylated-mu-opioid receptor-like immunoreactivity in the superficial dorsal horn of the mouse spinal cord. Mice with sciatic nerve ligation exhibited a significant suppression of the morp...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2003.09.077

    authors： Narita M,Kuzumaki N,Suzuki M,Narita M,Oe K,Yamazaki M,Yajima Y,Suzuki T

    更新日期：2004-01-09 00:00:00

  • No genetic association between polymorphisms in the Fyn kinase gene and age of schizophrenic onset.

    abstract：:Since the mRNA level of Fyn, a neurodevelopmental molecule, expression had been reported to be increased in postmortem schizophrenic prefrontal cortex and showed a strong correlation with age of disease onset, we investigated whether the three polymorphisms of the Fyn gene on genomic DNA (-93A/G, IVS10+37T/C and Ex12+...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(03)00310-0

    authors： Ohnuma T,Shibata N,Matsubara Y,Sato S,Yamashina M,Arai H

    更新日期：2003-05-29 00:00:00

  • Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type.

    abstract：:Post-mortem brain tissue from 15 patients dying with a diagnosis of senile dementia of Alzheimer type (SDAT) was compared with tissue obtained from 16 control patients at routine post-mortem. A significant fall in choline acetyltransferase (ChAT) activity was observed in the cortex, hippocampus and amygdala of the SDA...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(80)90177-9

    authors： Rossor MN,Emson PC,Mountjoy CQ,Roth M,Iversen LL

    更新日期：1980-12-01 00:00:00

  • Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms?

    abstract：:Cisplatin, oxaliplatin, paclitaxel, vincristine and bortezomib are some of the most effective drugs successfully employed (alone or in combinations) as first-line treatment for common cancers. However they often caused severe peripheral neurotoxicity and neuropathic pain. Structural deficits in Dorsal Root Ganglia and...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.neulet.2014.10.014

    authors： Carozzi VA,Canta A,Chiorazzi A

    更新日期：2015-06-02 00:00:00

  • Spatial direction of attention enhances right hemispheric event-related gamma-band synchronization in humans.

    abstract：:Gamma-band oscillations are related to sensory information processing and attention. To further illuminate the relationship of gamma-band activity and selective somatic attention, we have studied the effects of direction of attention on the stimuli of somatosensory evoked potentials. Responses during focused attention...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)00384-1

    authors： Gobbelé R,Waberski TD,Schmitz S,Sturm W,Buchner H

    更新日期：2002-07-12 00:00:00

  • Striatal dopamine in the response of brain and liver unsaturated and saturated free fatty acids following administration of C75 in CD-1 mice.

    abstract：:In order to clarify the mechanism of action of cerulenin analog, C75, known to suppress feeding behavior, food intake was measured in adult CD-1 male mice n=5 per group, treated i.p. with 10 and 20mg/kg of C75. Animals in both treatment groups had significantly lower 24h food consumption rate relative to the control g...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.12.019

    authors： Binienda ZK,Ross IA,Gough B,Riccio T,Kim CS,Ali SF

    更新日期：2010-01-29 00:00:00

  • A subset of nociceptin/orphanin FQ receptor-expressing neurons in the anterior hypothalamic area, as revealed in mice with lacZ reporter gene.

    abstract：:Nociceptin/orphanin FQ (N/OFQ) is an endogenous peptide agonist for the opioid receptor homolog, N/OFQ receptor, and serves for the central control of autonomic functions. Morphological details including the cell types that may account for such N/OFQ functions, however, remain unclear. By using X-gal histochemistry fo...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)01186-2

    authors： Houtani T,Ikeda M,Kase M,Sato K,Sakuma S,Kakimoto S,Ueyama T,Munemoto Y,Takeshima H,Sugimoto T

    更新日期：2003-01-02 00:00:00

  • The basal nucleus of Meynert in patients with progressive supranuclear palsy.

    abstract：:The neuronal number and nucleolar volume of the magnocellular population of the basal nucleus of Meynert in 6 patients with progressive supranuclear palsy (PSP) - one associated with Alzheimer's disease - were compared with those of 5 controls. In the 5 typical PSP cases, an age-dependent neuronal loss was demonstrate...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(84)90217-9

    authors： Tagliavini F,Pilleri G,Bouras C,Constantinidis J

    更新日期：1984-01-27 00:00:00

  • Lower excitability of the corticospinal tract to transcranial magnetic stimulation during lengthening contractions in human elbow flexors.

    abstract：:The purpose of this study was to characterize the neuromuscular control during shortening (SHO) and lengthening (LEN) contractions by investigating the input-output (I/O) property in the corticospinal tract. To this end, the relation between various stimulus intensities applied via transcranial magnetic stimulation an...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)02197-8

    authors： Sekiguchi H,Kimura T,Yamanaka K,Nakazawa K

    更新日期：2001-10-19 00:00:00

  • No psychological dependence after oral administration of morphine to rats.

    abstract：:Rats subjected to forced oral self-administration of morphine solutions without or in combination with two daily i.p. injections of morphine preferred drinking water when this was offered in addition to morphine solutions. The daily intake of morphine during the terminal phase of self-administration of morphine was 50...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(92)90476-n

    authors： Jurna I,Baldauf J,Zenz M

    更新日期：1992-04-13 00:00:00

  • Characterization of a novel processing pathway for Alzheimer's amyloid beta precursor protein.

    abstract：:Amyloid beta (A beta) is a normal proteolytic fragment of a large precursor protein (beta PP) which undergoes altered conformation, leading to fibril formation. Two main beta PP processing pathways have been described, and we are now reporting the characterization of a third beta PP pathway. A membrane-associated 16 k...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(94)90642-4

    authors： Ghiso J,Gardella JE,Liem L,Gorevic PD,Frangione B

    更新日期：1994-04-25 00:00:00

  • Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat.

    abstract：:The molecular regulation of seizure-induced neuronal death may involve interactions between proteins of the Bcl-2 and 14-3-3 families. To further examine these pathways we performed subcellular fractionation on hippocampi obtained following a brief period of status epilepticus in the rat. Western blotting determined s...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2003.11.048

    authors： Schindler CK,Shinoda S,Simon RP,Henshall DC

    更新日期：2004-02-19 00:00:00

  • Walking duration and slope steepness determine the effect of downslope walking on the soleus H-reflex pathway.

    abstract：:The purpose of this study was to determine if the effect of downslope walking (DSW) on spinal excitability depends on walking duration and slope steepness, and if findings from the soleus (Sol) generalize to the tibialis anterior (TA). Sol and TA Hmax and Mmax were measured before and after four DSW doses (time/slope,...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2016.12.048

    authors： Arnold E,Farmer B,Keightley M,Lee D,Rigel T,Hoque M,Sabatier MJ

    更新日期：2017-02-03 00:00:00

  • Inhibition of staurosporine-induced neuronal cell death by bisphenol A and nonylphenol in primary cultured rat hippocampal and cortical neurons.

    abstract：:We examined whether bisphenol A (BPA) and 4-nonylphenol (NP) influenced staurosporine-induced neuronal cell death in primary cultured rat hippocampal and cortical neurons. In hippocampal neurons, 17beta-estradiol (E2) (1 nM and 10 microM) and BPA (10 microM) significantly inhibited the staurosporine-induced release of...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2003.09.031

    authors： Negishi T,Ishii Y,Kyuwa S,Kuroda Y,Yoshikawa Y

    更新日期：2003-12-19 00:00:00

  • Somatotopical relationships between cortical activity and reflex areas in reflexology: a functional magnetic resonance imaging study.

    abstract：:We examined the somatotopical relationship between cortical activity and sensory stimulation of reflex areas in reflexology using functional magnetic resonance imaging. Three reflex areas on the left foot, relating to the eye, shoulder, and small intestine were stimulated during the experiment. A statistical analysis ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.10.022

    authors： Nakamaru T,Miura N,Fukushima A,Kawashima R

    更新日期：2008-12-19 00:00:00

  • The interaction of tacrine with benzodiazepine and GABA binding sites of guinea pig brain.

    abstract：:Tacrine (1,2,3,4-tetrahydro-9-acridinamine) inhibited binding of [3H]flunitrazepam to benzodiazepine receptors of guinea pig hippocampus with an inhibition constant of 46 microM at 2 degrees C and 37 degrees C. gamma-Aminobutyric acid (GABA) decreased the affinity of tacrine for the receptor, suggesting that tacrine m...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90473-7

    authors： Dawson RM,Poretski M

    更新日期：1991-08-19 00:00:00