Abstract:
:The effect of the adenosine (ADO) analogue 2-chloroadenosine (CADO) on frequency-induced long-term potentiation (LTP) of the responses evoked by stimulation of the Schaffer fibres and recorded in CA1 area was studied in hippocampal slices of the rat. CADP significantly decreased LTP of the population spikes (PS) (EC50 = 0.28 microM), and LTP of the field excitatory postsynaptic potentials (f.e.p.s.p) (EC50 = 0.33 microM). These effects were reversed by the ADO receptor antagonist 8-phenyltheophylline (8-PT) (2.5 microM). It is concluded that CADO decreases LTP through activation of a xanthine-sensitive ADO receptor.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
de Mendonça A,Ribeiro JAdoi
10.1016/0304-3940(90)90260-gsubject
Has Abstractpub_date
1990-10-02 00:00:00pages
107-11issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(90)90260-Gjournal_volume
118pub_type
杂志文章abstract::A novel preparation for the study of male and female sexual function in anesthetized, acutely spinalized rats is reported. In both sexes, the coitus reflex (the neuromuscular concomitants of sexual climax) could be elicited by mechanical stimulation of the distal urethra. It is concluded that the spinal sexual circuit...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90042-0
更新日期:1988-12-05 00:00:00
abstract::The high-affinity, sodium-dependent uptake of dopamine (DA) was inhibited by the pretreatment of synaptosomes with neuraminidase from Vibrio cholerae. The inhibition was of a non-competitive type, resulting in a 40% decrease of Vmax. Neither basal nor depolarization-stimulated release of DA was affected. Treatment of ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90179-0
更新日期:1987-11-10 00:00:00
abstract::Exposure to a single session of intense inescapable stressors results in elevations of plasma corticosterone levels selective to the trough of the circadian rhythm that last for several days after stressor cessation. In the present study, we examined whether this stress-induced alteration in the regulation of the circ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.10.016
更新日期:2005-02-01 00:00:00
abstract::Electroencephalogram (EEG) data is an effective indicator to evaluate driver fatigue. The 16 channels of EEG data are collected and transformed into three bands (θ, α, and β) in the current paper. First, 12 types of energy parameters are computed based on the EEG data. Then, Grey Relational Analysis (GRA) is introduce...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.11.014
更新日期:2012-01-11 00:00:00
abstract::Ibotenate induced a concentration- and largely calcium-dependent release of endogenous glutamate from guinea pig cerebro-cortical synaptosomes. In the absence of Mg2+, the response to ibotenate was enhanced through a mechanism involving N-methyl-D-aspartate (NMDA) receptors; this component was sensitive to the NMDA an...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(90)90373-h
更新日期:1990-03-26 00:00:00
abstract::This experiment has been designed to evaluate the basal serum BDNF level and memory performance, and also the change in BDNF in response to acute aerobic and anaerobic training in athletes and sedentary groups. Nineteen middle aged elite athletes (45-65 years) who used to be competing at domestic championship for more...
journal_title:Neuroscience letters
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neulet.2014.02.011
更新日期:2014-04-30 00:00:00
abstract::Transcranial direct current stimulation (tDCS) is a non-invasive technique that moderates cognitive and motor function. The effects of tDCS on cognitive and motor tasks vary among individuals. However, the source of the inter-individual variability remains unknown. The purpose of the present study was to examine wheth...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.04.022
更新日期:2013-06-17 00:00:00
abstract::Hemispheric asymmetries in spatial processing are generally considered to be responsible for the shorter reaction time (RT) of the left hand classically observed for right-handers when pointing at targets. Surprisingly, despite the special role which the right cerebral hemisphere is known to play in visual attention, ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02313-8
更新日期:2001-11-23 00:00:00
abstract::By the use of light microscopic immunohistochemistry it was shown that a significant population of small primary sensory afferents of guinea pig contains immunoreactivities to antisera directed against prodynorphin-opioid peptides, whereas immunoreactivities to antisera directed against opioid peptides exclusively con...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(85)90079-5
更新日期:1985-08-05 00:00:00
abstract::Manual actions and speech are connected: for example, grip execution can influence simultaneous vocalizations and vice versa. Our previous studies show that the consonant [k] is associated with the power grip and the consonant [t] with the precision grip. Here we studied whether the interaction between speech sounds a...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.05.024
更新日期:2017-06-09 00:00:00
abstract::The nucleus raphe magnus belongs to the thermoafferent system. Following iontophoretic choleratoxin b injections in its rostral part, a substantial to large number of anterogradely labeled varicose fibres were observed in the medial and lateral preoptic areas, the bed nucleus, the substantia innominata, the ventral pa...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)13013-5
更新日期:1996-10-04 00:00:00
abstract::A seizure disorder, characterized by sporadic tonic/clonic seizures has been identified in a strain of mice carrying the weaver (wv) gene. Breeding studies and a review of the literature indicate that this is either a property of the wv gene or linked to it tightly. ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90052-9
更新日期:1989-01-16 00:00:00
abstract::Abnormalities of cortical representational maps and their plasticity have been described in dystonia. A common polymorphism for BDNF has been associated with abnormal cortical plasticity, and thus might contribute to pathogenesis of dystonia in some subjects. As a first step towards this suggestion, the current study ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.10.059
更新日期:2010-01-01 00:00:00
abstract::Opioid-cholecystokinin (CCK) interactions at the spinal level were investigated by looking for possible modulations by various opioid agonists of the release of cholecystokinin-like material (CCKLM) from slices of the dorsal zone of the rat lumbar enlargement. K(+)-evoked CCKLM overflow was reduced by 0.1-10 microM of...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90094-a
更新日期:1991-04-01 00:00:00
abstract::Activations of the DLPFC and SMA have been shown to correlate with dual-task walking. However, very few investigations have directly perturbed the activations of these areas to establish a cause-and-effect relationship. The objectives of this study were: 1) to investigate the role of DLPFC and SMA in dual-task walking...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2019.01.004
更新日期:2019-04-17 00:00:00
abstract::The axonal efferents of neurons of the supraoptic nucleus area were studied by radioautography in the rat after discrete stereotaxic injections of [3H]leucine into this nucleus. Beside a densely labeled pathway running from the nucleus to the posterior pituitary through the internal median eminence, several of the vis...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90027-3
更新日期:1986-05-23 00:00:00
abstract::Neuronal recording and neuroimaging studies have shown that the primary motor area (M1) not only participates in motor execution, but is also engaged during movement preparation. The purpose of the present study was to map the distribution of the preparation- and execution-related activity within the contralateral M1 ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)01236-3
更新日期:2003-02-06 00:00:00
abstract::Mice were treated with N-2-chloroethyl-N-ethyl-2-bromobenzylamine hydrochloride (DSP4), which causes severe noradrenaline (NA) depletions in brain regions and the spinal cord, or vehicle i.p. They were tested 14 days later for antinociception induced by intrathecal injections of different doses of NA. A potentiation o...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(85)90222-8
更新日期:1985-08-16 00:00:00
abstract::To investigate whether there is a descending contribution to the spinal 5-hydroxytryptamine (5-HT) innervation in the lamprey, a primitive vertebrate, a study using retrograde transport of the fluorescent tracer Fast blue combined with 5-HT immunohistochemistry was conducted. Two to 4 weeks after an injection of Fast ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90207-7
更新日期:1986-06-06 00:00:00
abstract::It has been generally suggested that chewing produces an enhancing effect on cognitive performance-related aspects of memory by the test battery. Furthermore, recent studies have shown that chewing is associated with activation of various brain regions, including the prefrontal cortex. However, little is known about t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.03.033
更新日期:2008-05-09 00:00:00
abstract::The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01752-3
更新日期:2001-02-09 00:00:00
abstract::During early postnatal phase, the environment deeply affects developmental trajectories through epigenetic mechanisms that control the levels of key molecules for brain function, such as neurotrophins. Indeed, it has been shown that adverse early experiences induce epigenetic modifications leading to decreased brain d...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.03.038
更新日期:2011-05-20 00:00:00
abstract::Astrocytes have been implicated in axon guidance and synaptic regeneration in the retina and these processes involve activation of the high affinity nerve growth factor receptor, known as the tyrosine kinase A (TrkA) receptor. The purpose of the present study was to characterize the expression of TrkA in astrocytes of...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)01322-8
更新日期:2003-02-13 00:00:00
abstract::To study the central effects of adenosine on hypoxia, the influence of treatment by the A1 receptor agonist cyclohexyladenosine (1 microM) or by the antagonist theophylline (10 microM) was tested on cell damage in a model of neuronal culture. Whereas theophylline enhanced cell injury induced by 8 h hypoxia, cyclohexyl...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)91092-8
更新日期:1994-07-04 00:00:00
abstract::Auditory evoked potentials (AEPs) were recorded during presentation of stimuli of 1000 Hz (standard) and 2000 Hz (deviant) in trains of 10 tone bursts (one deviant per train) in the wake and rapid eye movement (REM) sleep states. The constant inter-stimulus interval (ISI) was 600 ms and the trains were separated by 3 ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00798-2
更新日期:1997-11-14 00:00:00
abstract::(1) This study shows the effects of bicuculline pretreatment on the GABAergic system in certain areas of the rat brain after acute ether and cold stress. (2) The spontaneous locomotor activity was diminished by either ether stress or cold stress or bicuculline. (3) Acute ether stress enhanced GABA concentration in the...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90863-x
更新日期:1994-07-18 00:00:00
abstract::Damage to sub-cortical white matter is a key substrate of vascular dementia (VaD) leading to deficits in executive function and cognitive processing speed. Dynamin1 is a 100 kDa protein, accounting for 0.4% of the total brain protein, and has a central role in many intracellular processes such as synaptic vesicle traf...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2014.01.045
更新日期:2014-03-20 00:00:00
abstract::The effects of electrical stimulation of the central (CE) and basolateral (BL) amygdaloid nuclei on pancreatic exocrine secretion were tested in urethane-anesthetized rats. Electrical stimulation (0.1 mA, 1 ms, 40 Hz) of the CE significantly increased basal and hormone (secretin+cholecystokinin-8)-infused pancreatic e...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90352-2
更新日期:1994-03-14 00:00:00
abstract::Lead is a neurotoxicant of immense public health importance. Epidemiology studies suggest that heavy metal exposure may be associated with an increased risk of cognitive decline, yet few studies to date have assessed the effect of adult lead exposure on cognitive behavior in animal models. Here, we exposed 6-week-old ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.09.060
更新日期:2017-11-20 00:00:00
abstract::The binding and pharmacological characteristics of [125I]iodomelatonin binding sites in human fetal brain membrane preparations were determined. Membrane preparations of the whole brain revealed a equilibrium binding constant (Kd) of 17.5 pmol/l with a total number of binding sites (Bmax) at 0.8 fmol/mg protein. Among...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90403-g
更新日期:1991-09-16 00:00:00