2-Chloroadenosine decreases long-term potentiation in the hippocampal CA1 area of the rat.

Abstract:

:The effect of the adenosine (ADO) analogue 2-chloroadenosine (CADO) on frequency-induced long-term potentiation (LTP) of the responses evoked by stimulation of the Schaffer fibres and recorded in CA1 area was studied in hippocampal slices of the rat. CADP significantly decreased LTP of the population spikes (PS) (EC50 = 0.28 microM), and LTP of the field excitatory postsynaptic potentials (f.e.p.s.p) (EC50 = 0.33 microM). These effects were reversed by the ADO receptor antagonist 8-phenyltheophylline (8-PT) (2.5 microM). It is concluded that CADO decreases LTP through activation of a xanthine-sensitive ADO receptor.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

de Mendonça A,Ribeiro JA

doi

10.1016/0304-3940(90)90260-g

subject

Has Abstract

pub_date

1990-10-02 00:00:00

pages

107-11

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(90)90260-G

journal_volume

118

pub_type

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