Abstract:
:Astrocytes have been implicated in axon guidance and synaptic regeneration in the retina and these processes involve activation of the high affinity nerve growth factor receptor, known as the tyrosine kinase A (TrkA) receptor. The purpose of the present study was to characterize the expression of TrkA in astrocytes of the adult pig and human retina. To this end, sections of human and pig retinas were immunolabeled with a combination of antibodies to glial fibrillary acidic protein (GFAP) and TrkA. Our study revealed that most of the GFAP-positive cells express TrkA, whereas a rare, novel subpopulation of astrocytes was found to be devoid of TrkA. Our results support the idea that astrocytes play an important neurotrophic role in the retina.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ruiz-Ederra J,Hitchcock PF,Vecino Edoi
10.1016/s0304-3940(02)01322-8keywords:
subject
Has Abstractpub_date
2003-02-13 00:00:00pages
127-30issue
3eissn
0304-3940issn
1872-7972pii
S0304394002013228journal_volume
337pub_type
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