Abstract:
:Prophylaxis of posttraumatic epilepsy will require a detailed knowledge of the epileptogenic pathophysiological processes that follow brain injury. Results from studies of experimental models and human epilepsy highlight alterations in GABAergic interneurons and formation of excessive new excitatory synaptic connectivity as prominent targets for prophylactic therapies. Promising laboratory results suggest that it will be possible to experimentally modify these aberrant processes and interfere with epileptogenesis. However, a number of key issues must be addressed before these results can be used to frame clinical antiepileptogenic therapy.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Li H,McDonald W,Parada I,Faria L,Graber K,Takahashi DK,Ma Y,Prince Ddoi
10.1016/j.neulet.2011.02.042subject
Has Abstractpub_date
2011-06-27 00:00:00pages
172-6issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(11)00209-6journal_volume
497pub_type
杂志文章,评审abstract::Our previous study has shown that both electroacupuncture (EA) and vagus nerve stimulation (VNS) can inhibit cortical epileptiform activities induced by pentylenetetrazole (PTZ). The current study compared the effects of EA and VNS on thalamic neuronal responses to PTZ-induced epileptiform activities. Under general an...
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