The use of ibotenic acid lesions for light and electron microscopic study of anterograde degeneration in the visual pathway of the cat.

abstract：:Previous studies have shown that the midbrain periaqueductal gray (PAG) projects to the ventrolateral medulla (VLM). Here, we studied PAG projections to the area of A1/C1 neurons in the VLM in the rat using phaseolus vulgaris leucoagglutinin (PHA-L) anterograde tracing combined with immunocytochemistry for tyrosine hy...

journal_title：Neuroscience letters

authors： Chen S,Aston-Jones G

更新日期：1995-08-04 00:00:00

abstract：:Changes in extracellular Ca2+ concentration ([Ca2+]e) evoked by transmitters and transmitter agonists, respectively, and by elevation of bath K+ concentration were recorded in isolated segmental ganglia of the leech Hirudo medicinalis using Ca(2+)-selective microelectrodes. A 1-min bath application of kainate (10 micr...

journal_title：Neuroscience letters

authors： Lohr C,Rose CR,Deitmer JW

更新日期：1996-02-16 00:00:00

abstract：:To investigate the contribution of nigral degeneration to the development of parkinsonism in the early stages of corticobasal degeneration (CBD), we measured the cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) in patients with early CBD (n = 5), and compared the levels with those in patients with early Par...

journal_title：Neuroscience letters

authors： Kanemaru K,Mitani K,Yamanouchi H

更新日期：1998-04-03 00:00:00

abstract：:Pharmacogenetic studies assessing the role of 5-HT(2A) receptor gene in antipsychotic efficacy yielded conflicting data. Phenotypical heterogeneity of schizophrenia might explain such discrepancies. For example, negative symptoms are known to reflect severity of illness and to restrain therapeutic response. On this ba...

journal_title：Neuroscience letters

authors： Hamdani N,Bonnière M,Adès J,Hamon M,Boni C,Gorwood P

更新日期：2005-03-22 00:00:00

abstract：BACKGROUND:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a subcortical, inherited, cerebral small vessel disease. Several studies have revealed the involvement of specific cortical regions. However, the structural brain alterations and their clinical correlation...

journal_title：Neuroscience letters

authors： Pan H,Huang Q,Ban S,Du X,Su J,Liu J

更新日期：2020-11-01 00:00:00

abstract：:Leucine-enkephalin-like immunoreactive (ENK-LI) afferent fibers to the feline homologue of the Onuf's nucleus (pudendal motoneurons) originate mainly from lamina X of the sacral cord. They make synaptic contacts chiefly upon dendrites of pudendal motoneurons; the synaptic terminals most often contain pleomorphic synap...

journal_title：Neuroscience letters

authors： Konishi A,Itoh K,Sugimoto T,Yasui Y,Kaneko T,Takada M,Mizuno N

更新日期：1985-10-24 00:00:00

abstract：:Disturbed motor control of the fingers, as revealed by the response to unexpected loading of an object held in a precision grip, or to finger perturbation during isometric holding, has been studied in patients with Huntington's disease (HD) and in normal subjects. In normal subjects unexpected loading elicited a refle...

journal_title：Neuroscience letters

authors： Fellows S,Schwarz M,Schaffrath C,Dömges F,Noth J

更新日期：1997-04-25 00:00:00

abstract：:Mounting evidence suggests a chronic pro-inflammatory state in individuals with bipolar disorder (BD). Stress exposure is known to exacerbate several inflammatory conditions as well as psychiatric disorders. Here, we analyzed plasma levels of pro-inflammatory cytokines and their soluble receptors to realistic acute ps...

journal_title：Neuroscience letters

authors： Wieck A,Grassi-Oliveira R,do Prado CH,Rizzo LB,de Oliveira AS,Kommers-Molina J,Viola TW,Marciano Vieira EL,Teixeira AL,Bauer ME

更新日期：2014-09-19 00:00:00

abstract：:In the real world, some of the auditory and visual information received by the human brain are temporally asynchronous. How is such information integrated in cognitive processing in the brain? In this paper, we aimed to study the semantic integration of differently asynchronous audio-visual information in cognitive pr...

journal_title：Neuroscience letters

authors： Liu B,Wu G,Wang Z,Ji X

更新日期：2011-07-01 00:00:00

abstract：:The aim of the present study was to investigate the intrathecal (i.t.) action of a selective A1-adenosine receptor agonist, R-phenylisopropyl adenosine (R-PIA), on tactile withdrawal thresholds in a rat model of mononeuropathy produced by sciatic chronic constriction injury (CCI). An additional aim was to examine whet...

journal_title：Neuroscience letters

authors： Cui JG,Sollevi A,Linderoth B,Meyerson BA

更新日期：1997-02-28 00:00:00

abstract：:Monosynaptic evoked field potentials (EPs) in response to paired-pulse stimulation (20 ms interval) were recorded in area CA1 and fascia dentata of the same animal in the course of development of a kindled focus in the CA1 region. A significant reduction of paired pulse depression in response to medium and high stimul...

journal_title：Neuroscience letters

authors： Kamphuis W,Gorter JA,Wadman WJ,Lopes da Silva FH

更新日期：1992-07-06 00:00:00

abstract：:Immunoelectron microscopy combined with a retrograde tracing technique was carried out to examine the synaptic interaction between neuropeptide Y (NPY)-like immunoreactive (LI) axon terminals and spinal motoneurons innervating bulbocavernosus muscles. Cell bodies and proximal dendrites of these motoneurons were freque...

journal_title：Neuroscience letters

authors： Kawano M,Sugita O,Inagaki S,Furuyama T,Takagi H

更新日期：1993-04-02 00:00:00

abstract：:Fibroblast growth factor (FGF), epidermal growth factor (EGF) and insulin added in combination to the culture medium in which normal human muscle was cultured caused a 4.0-fold (P less than 0.005) increase of the total number of nicotinic acetylcholine receptors (AChRs) and a 4.5-fold (P less than 0.001) increase in A...

journal_title：Neuroscience letters

authors： Askanas V,Cave S,Gallez-Hawkins G,Engel WK

更新日期：1985-10-24 00:00:00

abstract：:Alpha-2 macroglobulin (A2M) is a serum pan-protease inhibitor that is related with the pathogenesis of Alzheimer's disease (AD) through its ability to mediate amyloid beta degradation. Recently, it has been reported that the I1000V polymorphism in A2M gene might increase the risk of AD. In the present study, we invest...

journal_title：Neuroscience letters

authors： Shibata N,Ohnuma T,Takahashi T,Ohtsuka E,Ueki A,Nagao M,Arai H

更新日期：2000-08-25 00:00:00

abstract：:By using the monoclonal antibody Alz50, we studied the role of protein kinase C (PKC) in inducing A68 protein expression in a human neuronal cell line. Both phorbol 12-myristate 13-acetate and H7 strongly induced A68 protein, while HA1004 and calphoslin C had no effect. The results suggest that the inhibitor and activ...

journal_title：Neuroscience letters

authors： Zhang L

更新日期：1994-11-07 00:00:00

abstract：OBJECTIVES:Suicide attempt in schizophrenia is an important clinical issue. We performed a genome-wide association study to identify genetic markers, which increase the risk for suicide attempt in schizophrenia. METHODS:Suicide attempt lifetime was assessed in 121 schizophrenia patients and defined by the means of the...

journal_title：Neuroscience letters

authors： Bani-Fatemi A,Graff A,Zai C,Strauss J,De Luca V

更新日期：2016-05-27 00:00:00

abstract：:The nucleus accumbens (NAc) shell is closely associated with reward, psychiatric disorders (depression or schizophrenia), and drug abuse. Dopamine, released from the ventral tegmental area, is involved in these physiological functions and pathophysiological changes of NAc shell. Medium spiny neurons (MSNs), which are ...

journal_title：Neuroscience letters

authors： Kohnomi S,Ebihara K,Kobayashi M

更新日期：2017-01-01 00:00:00

abstract：:Fluoride-resistant acid phosphatase (FRAP) has been suggested as an enzymatic marker for nociceptive primary afferent terminals in the spinal dorsal horn, however there has not been demonstrated a direct functional relation between FRAP activity and an increased nociceptive transmission. For this purpose, we quantitat...

journal_title：Neuroscience letters

authors： Glykys J,Guadama M,Marcano L,Ochoa E,Eblen-Zajjur A

更新日期：2003-02-13 00:00:00

abstract：:Several studies demonstrated that the overexpression of miR-124 in neural stem cells (NSCs) could lead the NSCs to differentiate into neurons and astrocytes, which may be important for functional recovery in spinal cord injury. The present study attempted to explore the potential repairing effect of the NSCs transfect...

journal_title：Neuroscience letters

authors： Xu W,Li P,Qin K,Wang X,Jiang X

更新日期：2012-10-31 00:00:00

abstract：:During early postnatal phase, the environment deeply affects developmental trajectories through epigenetic mechanisms that control the levels of key molecules for brain function, such as neurotrophins. Indeed, it has been shown that adverse early experiences induce epigenetic modifications leading to decreased brain d...

journal_title：Neuroscience letters

authors： Branchi I,Karpova NN,D'Andrea I,Castrén E,Alleva E

更新日期：2011-05-20 00:00:00

abstract：:A quantitative analysis of cytochrome oxidase (CO) activity in histochemically stained sections of rat brain was developed using tissue standards and computerized image processing. Standards of brain paste containing known amounts of CO were cryosectioned and stained under the same conditions as brain sections. The gr...

journal_title：Neuroscience letters

authors： Gonzalez-Lima F,Garrosa M

更新日期：1991-02-25 00:00:00

abstract：:Both preischemic hyperglycemia and reduction of manganese superoxide dismutase activity are known to enhance neuronal death induced by transient cerebral ischemia. Transcriptional factor hypoxia-inducible factor 1 (HIF-1) regulates multiple downstream genes that modulate cell metabolism, survival, death, angiogenesis,...

journal_title：Neuroscience letters

authors： Bullock JJ,Mehta SL,Lin Y,Lolla P,Li PA

更新日期：2009-06-05 00:00:00

abstract：:To assess the neurotrophic effects of a nootropic drug, aniracetam, we studied neurite extension of mouse cerebellar granule cells in culture with low or with high K+ under different combinations of drugs and then immunohistochemically stained the cells with an antibody against L1, a neural cell adhesion molecule on c...

journal_title：Neuroscience letters

authors： Fushiki S,Matsumoto K,Nagata A

更新日期：1995-10-27 00:00:00

abstract：:Generalized epilepsy with febrile seizures plus (GEFS(+)) is a common familial epilepsy syndrome, which generally develops in childhood. GEFS(+) is caused by mutations in the sodium-channel α1-subunit (SCN1A). In this report, we investigated a Chinese family with an autosomal dominant form of GEFS(+). The affected GEF...

journal_title：Neuroscience letters

authors： Cui X,Zeng F,Liu Y,Zhang J,Archacki S,Zhan T,Du R,Tang Z,Liu J,Wang QK,Liu M

更新日期：2011-09-26 00:00:00

abstract：:Gelsolin (GSN) levels and matrix metalloproteinase 3 (MMP3) activity have been found to be altered in the plasma in patients with Alzheimer disease (AD). The aim of this study was to determine whether a combination of these proteins with clinical data is specific and sensitive enough for AD diagnosis. In 113 non-demen...

journal_title：Neuroscience letters

authors： Peng M,Jia J,Qin W

更新日期：2015-05-19 00:00:00

abstract：:The effects of several Ca2+ channel blockers were evaluated on inhibitory junction potential (IJP) evoked in rat colonic circular muscle by electrical field stimulation (EFS). Glass microelecrodes were used to record membrane potential of smooth muscle cells. IJPs were tetrodotoxin-sensitive (1 microM) and disappeared...

journal_title：Neuroscience letters

authors： Borderies JR,Jiménez M,Angel F

更新日期：1996-05-31 00:00:00

abstract：:The density of hippocampal adenosine A1 receptors was measured in autopsy samples of six patients with dementia with either Alzheimer (three) or sclerosis type pathology (three) in hippocampus and six control patients. Kinetic parameters (Bmax and KD) were determined by means of quantitative autoradiography using [3H]...

journal_title：Neuroscience letters

authors： Deckert J,Abel F,Künig G,Hartmann J,Senitz D,Maier H,Ransmayr G,Riederer P

更新日期：1998-03-06 00:00:00

abstract：:'Clipsin' and other peptide bond hydrolase activities that appear to be integral membrane proteins, including two implicated in the formation of the histological hallmarks of Alzheimer's disease, were assayed in the frontal and parietal cortex from a large (n = 45) series of postmortem human brains. Tissues were extra...

journal_title：Neuroscience letters

authors： Stratmann GC,Webster MT,Francis PT,Procter AW,Bowen DM

更新日期：1992-08-31 00:00:00

abstract：:The synaptic relationships between gamma-aminobutyric acid (GABA)-immunoreactive and enkephalin-immunoreactive profiles in the cat spinal cord were examined using combined pre-embedding immunoperoxidase and post-embedding immunogold electron microscopic immunocytochemistry. Although colchicine was not used, enkephalin...

journal_title：Neuroscience letters

authors： Liu H,Llewellyn-Smith IJ,Pilowsky P,Basbaum AI

更新日期：1992-04-13 00:00:00

abstract：:Using organotypic hippocampal slice cultures we have investigated the actions of Interleukin-1 (IL-1) in a number of injury paradigms. Low concentrations of IL-1 potentiated hypoxia-induced neurodegeneration whilst high concentrations had no effect. In contrast, higher concentrations of IL-1 were strongly neuroprotect...

journal_title：Neuroscience letters

authors： Pringle AK,Niyadurupola N,Johns P,Anthony DC,Iannotti F

更新日期：2001-06-01 00:00:00