Cerebrospinal fluid homovanillic acid levels are not reduced in early corticobasal degeneration.

abstract：:Nerve growth factor (NGF) initially interested neurobiologists because of its effects in the developing nervous system. It is now clear that NGF functions throughout the life of the animal with a wide repertoire of actions. In the sensory nervous system it primarily influences the structure and function of nociceptors...

journal_title：Neuroscience letters

authors： Petruska JC,Mendell LM

更新日期：2004-05-06 00:00:00

abstract：:We examined the suggestion that some of the processes subserving learning through action-observation and motor-execution are different because sensory motor reafference is not available while the limb is at rest in the former condition. We confirmed the action-observation and motor-execution groups learned equally the...

journal_title：Neuroscience letters

authors： Hayes SJ,Andrew M,Elliott D,Roberts JW,Bennett SJ

更新日期：2012-01-11 00:00:00

abstract：:In the present study, tyrosine hydroxylase (TH; EC 1.14.16.2) cDNA was transfected into cultured fibroblasts and the production of L-3,4-dihydroxyphenylalanine (L-DOPA) was determined. Type 2 TH cDNA was transfected into fibroblasts (NRK-49F) derived from the normal rat kidney, and the expression of the TH minigene wa...

journal_title：Neuroscience letters

authors： Uchida K,Ishii A,Kaneda N,Toya S,Nagatsu T,Kohsaka S

更新日期：1990-02-16 00:00:00

abstract：:Neural stem cell (NSC) transplantation has exhibited considerable therapeutic potential in spinal cord injury. However, most experiments in animals have been performed by injecting these cells directly into the injured spinal cord. A cardinal feature of NSCs is their exceptional migratory ability through the nervous s...

journal_title：Neuroscience letters

authors： Takeuchi H,Natsume A,Wakabayashi T,Aoshima C,Shimato S,Ito M,Ishii J,Maeda Y,Hara M,Kim SU,Yoshida J

更新日期：2007-10-16 00:00:00

abstract：:To investigate whether the xenon-induced inhibition of the transient receptor potential vanilloid type 1 (TRPV1) ion channel in rat dorsal root ganglion (DRG) neurons reduces nociceptive processing, we examined the effect of xenon in reducing the release of calcitonin gene-related peptide (CGRP) from those neurons. We...

journal_title：Neuroscience letters

authors： Calcott G,White JP,Nagy I

更新日期：2011-07-20 00:00:00

abstract：:To light illumination retinal amacrine cells respond with graded depolarization accompanied by a spike discharge. It has been assumed that the graded depolarization is produced solely by the excitatory synaptic inputs from bipolar cells. Here we demonstrate that a tetrodotoxin (TTX)-sensitive persistent current also c...

journal_title：Neuroscience letters

authors： Watanabe S,Satoh H,Koizumi A,Takayanagi T,Kaneko A

更新日期：2000-01-07 00:00:00

abstract：:Histone modifications, such as lysine methylation, acetylation and ubiquitination, are epigenetic tags that shape the chromatin landscape and regulate transcription required for synaptic plasticity and memory. Here, we show that transcription-promoting histone H3 trimethylated at lysine 4 (H3K4me3), histone H3 acetyla...

journal_title：Neuroscience letters

authors： Bach SV,Tacon PR,Morgan JW,Hegde AN

更新日期：2015-03-30 00:00:00

abstract：:Microglia are resident phagocytic cells in the central nervous system (CNS), and can be activated in response to various stimuli including neurotransmitters. Using fura-2 imaging, we investigated the effects of carbachol (CCh), a cholinergic agonist, on [Ca2+]i in cultured human microglia. Treatment of microglia with ...

journal_title：Neuroscience letters

authors： Zhang L,McLarnon JG,Goghari V,Lee YB,Kim SU,Krieger C

更新日期：1998-10-09 00:00:00

abstract：:This study was aimed to evaluate effects of peptides from Phascolosoma esculenta and its ferrous-chelating peptides on spatial learning and memory in mice by Morris water maze test. 100mg/kg peptide on spatial learning and memory function about quadrant time and passing times through the platform better than 50 and 15...

journal_title：Neuroscience letters

authors： Liu L,Cao J,Chen J,Zhang X,Wu Z,Xiang H

更新日期：2016-09-19 00:00:00

abstract：:A critical component of the cellular stress response, the p53 tumor suppressor protein must be functional for many cancer therapies to be effective. Adjuvant therapies that augment p53 function are predicted to sensitize tumor cells to cancer therapies that rely upon p53 for their efficacy. Of those strategies current...

journal_title：Neuroscience letters

authors： Ghassemifar S,Mendrysa SM

更新日期：2012-03-28 00:00:00

abstract：:Postmitotic neurons were generated from the human NT2 teratocarcinoma cell line in a novel cell aggregate differentiation procedure. The NT2 model neurons express punctate immunoreactivity for synapsin and for cell markers related to GABAergic and glutamatergic neurotransmission. Using the outside-out patch-clamp conf...

journal_title：Neuroscience letters

authors： Podrygajlo G,Song Y,Schlesinger F,Krampfl K,Bicker G

更新日期：2010-01-14 00:00:00

abstract：:We have studied nicotinic acetylcholine receptors in spontaneously hypertensive 'stroke prone' (SHsp) rats. We found a significant decrease in 125I-alpha-bungarotoxin binding and alpha7 subunit mRNA levels in cortical areas of the SHsp rats with respect to Wistar Kyoto (WKy) normotensive rats. Antihypertensive drug tr...

journal_title：Neuroscience letters

authors： Ferrari R,Frasoldati A,Leo G,Torri C,Zini I,Agnati LF,Zoli M

更新日期：1999-12-31 00:00:00

abstract：:The present study is designed to screen the effect of syringin, an active principle purified from the rhizome and root parts of Eleutherococcus senticosus (Araliaceae), on the plasma glucose and investigate the possible mechanisms. Plasma glucose decreased in a dose-dependent manner 60 min after intravenous injection ...

journal_title：Neuroscience letters

authors： Liu KY,Wu YC,Liu IM,Yu WC,Cheng JT

更新日期：2008-03-28 00:00:00

abstract：:The release of endogenous calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) from slices of dorsal and ventral thoraco-lumbar spinal cord was examined using a fixed volume incubation technique and radioimmunoassay. Incubation with potassium (25-100 mM) produced a dose-related increase in basal CGRP-LI in ...

journal_title：Neuroscience letters

authors： Scott MA,Fone KC

更新日期：1994-07-04 00:00:00

abstract：:Cortical cells in primary culture contain active proteolytic enzymes capable of cleaving nociceptin/orphanin FQ (N/OFQ) and dynorphins to shorter, bioactive fragments. Cells were divided into subpopulations (neurons, astrocytes and oligodendrocytes), and the metabolic pathways in particular populations of the cells we...

journal_title：Neuroscience letters

authors： Suder P,Bogusiewicz A,Rolka K,Laidler P,Kotlinska J,Silberring J

更新日期：2003-09-18 00:00:00

abstract：:In 8 subjects the spontaneous termination of sleep was determined after repetitive exposure to either bright or dim light, between 6.00 and 9.00 h, on 3 days preceding sleep assessment. Sleep duration was significantly shorter following bright light than following dim light. During sleep the time course of EEG energy ...

journal_title：Neuroscience letters

authors： Dijk DJ,Visscher CA,Bloem GM,Beersma DG,Daan S

更新日期：1987-01-14 00:00:00

abstract：:The time-variant quadratic phase coupling (QPC) in trace alternant (TA) EEG patterns in healthy full-term neonates (quiet sleep) was investigated by means of time-variant bispectral analysis. The frequency plain 1-1.5 Hz <=> 3.5-4.5 Hz was used as the region-of-interest. QPC rhythms with a frequency of approximately 0...

journal_title：Neuroscience letters

authors： Schwab K,Putsche P,Eiselt M,Helbig M,Witte H

更新日期：2004-10-21 00:00:00

abstract：:Surface molecules play important roles in a wide range of cellular functions, yet little has been reported regarding the expression of such markers by neural stem cells. Here, multipotent human neural progenitor cells (hNPCs) were expanded as a monolayer in the presence of fibroblast/epidermal growth factor, harvested...

journal_title：Neuroscience letters

authors： Klassen H,Schwartz MR,Bailey AH,Young MJ

更新日期：2001-10-26 00:00:00

abstract：:The restoration of motor function is important in daily life in patients with brain damage. Although attentional concentration can affect motor function, most physical therapists focus only on therapeutic exercise. Therefore, we investigated changes in motor function in patients with high attentional concentration dur...

journal_title：Neuroscience letters

authors： Ha SY,Sung YH

更新日期：2020-09-25 00:00:00

abstract：:Recent evidence has suggested that down-regulation of somatostatin (SST) expression in the human brain during early stages of aging leads to an elevation in the steady-state levels of Abeta and therefore may be involved in Alzheimer's disease (AD) progression. We hypothesized that alterations in the SST gene might alt...

journal_title：Neuroscience letters

authors： Xue S,Jia L,Jia J

更新日期：2009-11-13 00:00:00

abstract：:Molecular mechanisms regulating positions of oligodendrocyte precursor cells (OPCs) remain unclear in developing cerebral cortex. To explore the mechanisms, we investigated how Plexin-A4, receptor of Semaphorin in OPCs, is involved in the positioning. We found that Plexin-A4 knockout mice exhibited (1) an increased nu...

journal_title：Neuroscience letters

authors： Okada A,Tomooka Y

更新日期：2012-05-16 00:00:00

abstract：:We studied axonal branching of 14 parabrachial nucleus neurons, activated antidromically from 2 of the 3 stimulation sites, i.e. the ipsi- and contralateral thalamic taste area (TTAs) and the ipsilateral central nucleus of the amygdala (CA). Making use of antidromic latencies, collision times and refractory periods at...

journal_title：Neuroscience letters

authors： Hayama T,Ogawa H

更新日期：1987-12-16 00:00:00

abstract：:Experiments were performed to test several predictions of the hypothesis that activity pattern-dependent changes in intracellular free calcium concentration ([Ca2+]i) might play a role in the translation of altered patterns of neuronal activity into changes in neurotransmitter gene expression. It was shown that (1) th...

journal_title：Neuroscience letters

authors： Hodaie M,Jeevaratnam P,Salter MW,Roach A

更新日期：1995-02-13 00:00:00

abstract：:The distribution pattern of sialylated glycoproteins in the hippocampal formation of 9-week-old and 29-month-old rats was examined using Maackia amurensis lectin, specific for Sia alpha2-3Gal, and Sambucus sieboldiana agglutinin specific for Sia alpha2-6Gal(GalNAc), and a monoclonal antibody for a linear homopolymer o...

journal_title：Neuroscience letters

authors： Sato Y,Endo T

更新日期：1999-02-26 00:00:00

abstract：:The present study was designed to test the hypothesis that alpha-tocopherol (Vit. E) and pyrrolidine dithiocarbamate (PDTC) might exert direct effects on alcohol-induced contractions of canine basilar cerebral arteries. After precontraction of arterial ring segments with ethanol, PDTC (10(-8)-10(-6) M) and Vit. E (10(...

journal_title：Neuroscience letters

authors： Li W,Zheng T,Altura BT,Altura BM

更新日期：2001-03-30 00:00:00

abstract：:Dependency of taste buds and taste papillae on innervation has been debated for a long time. Previous research showed neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), play an important role for the establishment of the lingual gustatory and somatosensory innervation. BDNF null mutant ...

journal_title：Neuroscience letters

authors： Ito A,Nosrat IV,Nosrat CA

更新日期：2010-03-08 00:00:00

abstract：:Occurring at rates up to 6-7 syllables per second, speech perception and understanding involves rapid identification of speech sounds and pre-activation of morphemes and words. Using event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), we investigated the time-course and neural sources of ...

journal_title：Neuroscience letters

authors： Roll M,Söderström P,Frid J,Mannfolk P,Horne M

更新日期：2017-09-29 00:00:00

abstract：:Alterations in dendritic spine densities and morphologies have been correlated with the abnormal functioning of the synapse. Specifically the metabotropic glutamate receptor 5 (mGluR5) has been implicated in dendrogenesis and spineogenesis, since its activation triggers various signaling cascades that have been demons...

journal_title：Neuroscience letters

authors： Chen CC,Lu HC,Brumberg JC

更新日期：2012-08-22 00:00:00

abstract：:Treatment with agmatine, decarboxylated arginine, proved to be non-toxic and to exert neuroprotective effects in several models of neurotoxic and ischemic brain and spinal cord injuries. Here we sought to find out whether agmatine treatment would also prove beneficial in a rat spinal cord ischemia model (balloon occlu...

journal_title：Neuroscience letters

authors： Gilad GM,Gilad VH

更新日期：2000-12-22 00:00:00

abstract：:Local cerebral glucose utilization (LCGU) was measured during spontaneous waking and slow wave sleep (SWS) by an adaptation of the [14C]deoxyglucose method to the free moving cat. In awake animals heterogeneous rates of LCGU were observed throughout the brain with values extending from 8 mumol x 100 g-1 x min-1 for wh...

journal_title：Neuroscience letters

authors： Petitjean F,Seguin S,Des Rosiers MH,Salvert D,Buda C,Janin M,Debilly G,Jouvet M,Bobillier P

更新日期：1982-09-20 00:00:00