mGluR5 knockout mice display increased dendritic spine densities.

abstract：:Presenilin 1 mutations are the major cause of autosomal dominant Alzheimer's disease. Here we present evidence that pathogenic mutations in putative transmembrane domains 1, 2, 3, 4 and 6 align along helical faces, thus supporting the view that these are indeed transmembrane domains, and suggesting that disruption of ...

journal_title：Neuroscience letters

authors： Hardy J,Crook R

更新日期：2001-06-29 00:00:00

abstract：:In this study, we investigated two newly reported polymorphisms in association with late onset Alzheimer's disease (AD) in Chinese. They were a -491 A/T polymorphism in the Apolipoprotein E (APOE) promoter region and a five base pair deletion at exon 18 of alpha2-Macroglobin (A2M). There were 196 AD and 180 normal con...

journal_title：Neuroscience letters

authors： Chen L,Baum L,Ng HK,Chan LY,Sastre I,Artíga MJ,Valdivieso F,Bullido MJ,Chiu HF,Pang CP

更新日期：1999-07-16 00:00:00

abstract：:The goal of this paper is to study possible differences between the processing of inflectional vs. derivational morphology in Spanish word recognition using electrophysiological measures. A lexical decision task to target words preceded by morphological-related (or unrelated) primes was used. The orthographic and phon...

journal_title：Neuroscience letters

authors： Alvarez CJ,Urrutia M,Domínguez A,Sánchez-Casas R

更新日期：2011-02-18 00:00:00

abstract：:Opiate withdrawal syndrome is temporally associated with the hyperactivity of locus coeruleus neurons. Previous studies have shown that this hyperactivity, at least in part, results from the activity of excitatory afferents which mainly include the orexinergic neurons of hypothalamus and glutamatergic neurons of parag...

journal_title：Neuroscience letters

authors： Hooshmand B,Azizi H,Javan M,Semnanian S

更新日期：2017-01-01 00:00:00

abstract：:The Gallyas-Braak silver impregnation method revealed neurons containing well-defined intraneuronal granules in both Alzheimer's disease and normal control brains. The granules were immunostained prominently with the Alz-50 antibody and, to a lesser degree, with the tau-2 antibody, but not with other anti-tau antibodi...

journal_title：Neuroscience letters

authors： Ikeda K,Akiyama H,Arai T,Kondo H,Haga C,Iritani S,Tsuchiya K

更新日期：1998-12-18 00:00:00

abstract：:Peripheral nerve damage causes a dramatic alteration to the gene expression in primary sensory neurons, changes within the neuronal cell body giving rise to an altered phenotype, adapted for axonal regeneration. Such changes suggest an alteration in activity, or levels, of cellular transcription factors. The POU famil...

journal_title：Neuroscience letters

authors： Begbie JL,Wood JN,Anderson PN,Latchman DS

更新日期：1996-04-05 00:00:00

abstract：:The motor activity of the rat bladder elicited by transmural electrical stimulation was abolished in the presence of 200 nM tetrodotoxin but not of 1 microM atropine plus 3.4 microM guanethidine. Tissue preincubation with 20 microM, alpha, beta-methylene ATP reduced but did not obliterate the electrically-induced moto...

journal_title：Neuroscience letters

authors： Acevedo CG,Lewin J,Contreras E,Huidobro-Toro JP

更新日期：1990-05-31 00:00:00

abstract：:A hybridoma cell line secreting a monoclonal antibody against catalytic subunits of acetylcholinesterase in the electric organ of Narke japonica has been obtained by using a mouse immunized with the nerve terminal membranes prepared from the electric organ of Narke japonica. This monoclonal antibody (Nj-501) reacted w...

journal_title：Neuroscience letters

authors： Abe T,Sakai M,Saisu H

更新日期：1983-07-15 00:00:00

abstract：BACKGROUND:Down syndrome (DS) is caused by either complete or partial triplication of chromosome 21, affecting approximately 1/1000 live births, and it is widely accepted that individuals with DS are more likely to develop dementia of Alzheimer's disease (DAD) compared with the general population. Many studies have inv...

journal_title：Neuroscience letters

authors： Patel A,Rees SD,Kelly MA,Bain SC,Barnett AH,Thalitaya D,Prasher VP

更新日期：2011-01-07 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine involved in the development and maintenance of inflammatory and neuropathic pain conditions. The mechanisms by which TNF-alpha elicits pain behavior are still incompletely understood. Numerous studies suggest that TNF-alpha sensitizes primary affere...

journal_title：Neuroscience letters

authors： Czeschik JC,Hagenacker T,Schäfers M,Büsselberg D

更新日期：2008-04-04 00:00:00

abstract：:The main purpose of the present paper was: (1) to study the phase synchronization pattern in the gamma-band while performing the classical Shepard-Metzler task of mental rotation; (2) to investigate the role of musical training; and (3) to study hemispheric differences in the degree of synchronization during mental ro...

journal_title：Neuroscience letters

authors： Bhattacharya J,Petsche H,Feldmann U,Rescher B

更新日期：2001-09-21 00:00:00

abstract：:Whale brains have attracted the attention of neuroscientists but there are only sparse studies on whale glial cells. Here we report on immunolabeling of astrocytes by antibodies to glial fibrillary acidic protein (GFAP) or protein S-100 beta (both by the streptavidin/biotin technique), and labeling of microglial cells...

journal_title：Neuroscience letters

authors： Pritz-Hohmeier S,Härtig W,Behrmann G,Reichenbach A

更新日期：1994-02-14 00:00:00

abstract：:Neural cell adhesion molecules (NCAMs) are members of the immunoglobulin superfamily and are involved in synaptic rearrangements in the mature brain. There are three major NCAM forms: NCAM 180, NCAM 140 and NCAM 120. Several studies report that NCAMs play a central role in memory. In the present study we investigated ...

journal_title：Neuroscience letters

authors： Baydas G,Nedzvetsky VS,Nerush PA,Kirichenko SV,Demchenko HM,Reiter RJ

更新日期：2002-06-28 00:00:00

abstract：:Immunoreactive beta-endorphin is localized mainly in the synaptosome-enriched subcellular fraction from rat hypothalami. In this report, we demonstrate that release of immunoreactive beta-endorphin from the synaptosome-enriched subcellular fraction is increased by 150% in a medium containing high potassium. This stimu...

journal_title：Neuroscience letters

authors： Fukata J,Nakai Y,Imura H

更新日期：1980-08-01 00:00:00

abstract：:Copper, manganese and zinc were measured by flameless atomic absorption spectrophotometry in the developing brain of normal and quaking mice. The latter is a neurological mutant presenting early arrest of myelination. Copper concentration was increased by 200% between 10 and 20 days after birth and then leveled off in...

journal_title：Neuroscience letters

authors： Cloëz I,Bourre JM

更新日期：1987-12-16 00:00:00

abstract：:The effects of micro-electrophoretically applied melatonin on the electrical activity of Purkinje cells in the cerebellum of anaesthetized pigeons were studied. The proportion of excitatory and inhibitory responses to the pineal indoleamine varied significantly depending on whether the cells were tested during the day...

journal_title：Neuroscience letters

authors： Demaine C,Semm P

更新日期：1986-12-12 00:00:00

abstract：:It is known that articulating different syllables is linked to different grasp actions, e.g. [ti] is linked to precision grip, and [kɑ] to power grip. The aim of the present study was to test whether articulating or hearing these syllables would result in an increased activity in the representation of hand muscles inv...

journal_title：Neuroscience letters

authors： Komeilipoor N,Tiainen M,Tiippana K,Vainio M,Vainio L

更新日期：2016-05-04 00:00:00

abstract：:Previous studies using 2-deoxyglucose (2-DG) autoradiography have demonstrated that the suprachiasmatic nucleus (SCN) of the hypothalamus, a putative neural circadian pacemaker, displays circadian rhythmicity in its metabolic activity. In the present study, we show that distinct circadian variations in 2-DG uptake occ...

journal_title：Neuroscience letters

authors： Rosenwasser AM,Trubowitsch G,Adler NT

更新日期：1985-07-31 00:00:00

abstract：:In 16 rats, the extensor digitorum longus (EDL) - a fast muscle - was grafted, complete with its innervation, into the bed of the (removed) soleus - a slow muscle. Following the transposition, performed on one side only, EDL recovered and showed the contraction time of the contralateral EDL that served as control. How...

journal_title：Neuroscience letters

authors： Gutmann E

更新日期：1976-07-01 00:00:00

abstract：:The present study is designed to screen the effect of syringin, an active principle purified from the rhizome and root parts of Eleutherococcus senticosus (Araliaceae), on the plasma glucose and investigate the possible mechanisms. Plasma glucose decreased in a dose-dependent manner 60 min after intravenous injection ...

journal_title：Neuroscience letters

authors： Liu KY,Wu YC,Liu IM,Yu WC,Cheng JT

更新日期：2008-03-28 00:00:00

abstract：:The distribution and origin of axon terminals containing nitric oxide synthase (NOS) were examined in the nucleus of the solitary tract (NST) of the rat by NADPH diaphorase histochemistry combined with nodose ganglionectomy. Axon terminals with NADPH diaphorase activity were densely distributed in the middle and cauda...

journal_title：Neuroscience letters

authors： Lü Y,Ding YQ,Qin BZ,Li JS

更新日期：1994-04-25 00:00:00

abstract：:Technologies for wireless telecommunication systems using millimeter waves (MMW) will be widely deployed in the near future. Forthcoming applications in this band, especially around 60GHz, are mainly developed for high data-rate local and body-centric telecommunications. At those frequencies, electromagnetic radiation...

journal_title：Neuroscience letters

authors： Haas AJ,Le Page Y,Zhadobov M,Sauleau R,Le Dréan Y

更新日期：2016-04-08 00:00:00

abstract：:Peripheral neuropathic pain is a common complication in the diabetic patients, and the underlying central mechanism remains unclear. Forebrain anterior cingulate cortex (ACC) is critically involved in the supraspinal perception of physical and affective components of noxious stimulus and pain modulation. Excitatory gl...

journal_title：Neuroscience letters

authors： Li W,Wang P,Li H

更新日期：2014-05-07 00:00:00

abstract：:Functioning of the hypothalamo-pituitary-adrenocortical axis was assessed in rats treated with DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine), a selective noradrenergic neurotoxin. Although adrenal weights were slightly increased 10 days after DSP-4 injection, basal plasma corticosterone levels were unaltered co...

journal_title：Neuroscience letters

authors： Dooley DJ,Hunziker G,Häusler A

更新日期：1984-05-18 00:00:00

abstract：:Generation of free radicals and subsequent lipid peroxidation have been proposed to contribute to delayed tissue damage following traumatic spinal cord injury (SCI). Ubiquinols (reduced coenzyme Q), ascorbate (vitamin C), and alpha-tocopherol (vitamin E) are endogenous antioxidants; decreases in tissue levels of these...

journal_title：Neuroscience letters

authors： Lemke M,Frei B,Ames BN,Faden AI

更新日期：1990-01-01 00:00:00

abstract：:It has been hypothesized that auditory temporal processing plays a major role in the aetiology of dyslexia. Event-related brain potentials (mismatch negativity, MMN) of auditory temporal processing were assessed in 15 dyslectic adults and 20 controls. A complex tonal pattern was used where the difference between stand...

journal_title：Neuroscience letters

authors： Schulte-Körne G,Deimel W,Bartling J,Remschmidt H

更新日期：1999-11-26 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) is enriched in the central nervous system, including the dopamine responsive regions such as the striatum and medial prefrontal cortex (mPFC). The kinase is sensitive to changing cellular and synaptic input and is implicated in the regulation of synaptic transmission and...

journal_title：Neuroscience letters

authors： Mao LM,Wang JQ

更新日期：2019-04-23 00:00:00

abstract：:Successful transplantations have been made of cultured explants of human fetal spinal cord into surgically created cavities in the motor cortical area of non-immunosuppressed young adult rats. The cultured cells were marked by brief incubation with Phaseolus vulgaris leucoagglutinin (PHA) just prior to transplantation...

journal_title：Neuroscience letters

authors： Kamo H,Kim SU,McGeer PL,Araki M,Tomimoto H,Kimura H

更新日期：1987-05-06 00:00:00

abstract：:Brain pericytes are involved in neurovascular dysfunction, neurodegeneration and/or neuroinflammation. In the present study, we focused on the proinflammatory properties of brain pericytes to understand their participation in the induction of inflammation at the neurovascular unit (NVU). The NVU comprises different ce...

journal_title：Neuroscience letters

authors： Matsumoto J,Takata F,Machida T,Takahashi H,Soejima Y,Funakoshi M,Futagami K,Yamauchi A,Dohgu S,Kataoka Y

更新日期：2014-08-22 00:00:00

abstract：:A partially purified toxin obtained from the coral reef crab, Lophozozymus pictor was found to be a potent inhibitor of Na+-dependent [14C]-GABA uptake by rat brain synaptosomes. Inhibition was potentiated in the presence of external K+. The I50 value for the toxin was found to be in the region of 10 microgram/ml at a...

journal_title：Neuroscience letters

authors： Tan CH,Abkowitz SJ

更新日期：1979-10-01 00:00:00