Lophozozymus pictor toxin: a potent inhibitor of synaptosomal GABA uptake.

Abstract:

:A partially purified toxin obtained from the coral reef crab, Lophozozymus pictor was found to be a potent inhibitor of Na+-dependent [14C]-GABA uptake by rat brain synaptosomes. Inhibition was potentiated in the presence of external K+. The I50 value for the toxin was found to be in the region of 10 microgram/ml at a GABA concentration of 2 microM. The inhibition showed substrate competition.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Tan CH,Abkowitz SJ

doi

10.1016/0304-3940(79)96171-8

subject

Has Abstract

pub_date

1979-10-01 00:00:00

pages

339-42

issue

2-3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(79)96171-8

journal_volume

14

pub_type

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