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Glufosinate ammonium stimulates nitric oxide production through N-methyl D-aspartate receptors in rat cerebellum.

Abstract：

:Glufosinate ammonium, a structural analogue of glutamate, is an active herbicidal ingredient. The neuronal activities of this compound were investigated by use of a microdialysis system that allowed us to measure nitric oxide production in the rat cerebellum in vivo. Kainate (0.3-30 nmol/10 microliter), N-methyl-D-aspartate (NMDA) (3-300 nmol/10 microliter) and glufosinate ammonium (30-3000 nmol/10 microliter), which were administered through the microdialysis probe at a rate of 1 microliter/min for 10 min, stimulated nitric oxide production. The glufosinate ammonium-elicited increase in nitric oxide production was suppressed by an inhibitor of nitric oxide synthase and was antagonized by NMDA receptor antagonists, but not by a kainate/(+/-)-alphaamino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist. These results suggest that glufosinate ammonium stimulates nitric oxide production through NMDA receptors.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Nakaki T,Mishima A,Suzuki E,Shintani F,Fujii T

doi

10.1016/s0304-3940(00)01363-x

keywords:

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

209-12

issue

3

eissn

0304-3940

issn

1872-7972

pii

S030439400001363X

journal_volume

290

pub_type

杂志文章

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