Abstract：
:The association between (GT)n dinucleotide repeats in monoamine oxidase gene loci, monoamine oxidase A (MAOA) and B (MAOB), and Parkinson's disease (PD), Alzheimer's disease (AD), and Lewy body variant (LBV) of AD were determined. MAOA-GT polymorphisms were significantly associated with pure AD and LBV. MAOA-GT allele 113 was excessively represented in pure AD and LBV compared with controls. Furthermore, the frequency of females homozygous for MAOA-GT allele 113 was higher in pure AD and LBV than controls by 2.79- and 2.77-fold, respectively. In contrast, there was no association between MAOA-GT or MAOB-GT polymorphisms and PD. These results suggest that polymorphisms within the MAOA gene may have implication in AD pathology shared by pure AD and LBV.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Takehashi M,Tanaka S,Masliah E,Ueda Kdoi
10.1016/s0304-3940(02)00258-6keywords:
subject
Has Abstractpub_date
2002-07-19 00:00:00pages
79-82issue
2eissn
0304-3940issn
1872-7972pii
S0304394002002586journal_volume
327pub_type
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