Abstract：
:Chronic increases in spontaneous multiunit activity can be induced in the dorsal cochlear nucleus (DCN) of hamsters by intense sound exposure (Kaltenbach and McCaslin, 1996). It has been hypothesized that this hyperactivity may represent a neural code that could underlie the sound percepts of tinnitus. The goal of the present study was to determine whether hyperactivity could be demonstrated in animals that had previously been tested for tinnitus, and, if so, whether animals differing in their behavioral evidence for tinnitus also differ in their levels of spontaneous activity. The results showed not only that levels of activity in exposed animals were higher than those in control animals, but the degree to which the activity was increased was related to the strength of the behavioral evidence for tinnitus. These findings are consistent with the hypothesis that hyperactivity in the DCN may be a physiological correlate of noise-induced tinnitus.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kaltenbach JA,Zacharek MA,Zhang J,Frederick Sdoi
10.1016/j.neulet.2003.10.038keywords:
subject
Has Abstractpub_date
2004-01-23 00:00:00pages
121-5issue
1-2eissn
0304-3940issn
1872-7972pii
S0304394003012321journal_volume
355pub_type
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