Abstract:
:Phencyclidine (PCP) is known to be an inhibitor of serotonin (5-HT) uptake and to increase serotonergic activity. The development of tolerance to serotonergic stereotyped behaviors induced by repeated PCP treatment and changes of 5-HT transporters were examined. Backpedalling was significantly reduced in frequency following 14 days PCP treatment (7.5 mg/kg per day). Furthermore, repeated PCP treatment decreased the equilibrium dissociation constant (Kd) of [3H]paroxetine binding to 5-HT transporters in whole brain excluding the cerebellum without any change of maximum number of binding sites (Bmax). Single treatment with PCP failed to change binding parameters. These results indicate that repeated PCP treatment causes tolerance in serotonergic stereotyped behavior and increases affinity of 5-HT transporters for [3H]paroxetine binding. The increased affinity of 5-HT transporters could represent compensatory responses to chronic inhibition of 5-HT uptake by PCP.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hori T,Abe S,Baba A,Suzuki T,Shiraishi Hdoi
10.1016/s0304-3940(99)00991-xkeywords:
subject
Has Abstractpub_date
2000-02-11 00:00:00pages
53-6issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00991-Xjournal_volume
280pub_type
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