Abstract:
:Alternative cleavage of the amyloid precursor protein (APP) results in generation and secretion of both soluble APP (sAPP) and beta-amyloid (Abeta). Abeta is the main component of the amyloid depositions in the brains of Alzheimer's disease (AD) patients. Using Western blotting, we compared the levels of alpha-secretase cleaved sAPP, beta-secretase cleaved sAPP and total sAPP, in cerebrospinal fluid (CSF) from 13 sporadic AD patients and 13 healthy controls. Our findings show significant amounts of beta-secretase cleaved sAPP in CSF. There was no statistically significant difference in the levels of beta-secretase cleaved sAPP between AD patients and controls. The levels of alpha-secretase cleaved sAPP and total sAPP were, however, found to be significantly lower in the AD patients than in the controls.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sennvik K,Fastbom J,Blomberg M,Wahlund LO,Winblad B,Benedikz Edoi
10.1016/s0304-3940(99)00929-5keywords:
subject
Has Abstractpub_date
2000-01-14 00:00:00pages
169-72issue
3eissn
0304-3940issn
1872-7972pii
S0304394099009295journal_volume
278pub_type
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