Brain-wide map of projections from mice ventral subiculum.

Abstract:

:The hippocampal formation plays a critical role in episodic memory formation and spatial navigation. Within the hippocampus, the subiculum is considered to be a hub connecting the hippocampal formation to the remainder of the brain. There are functional differences between the dorsal and ventral part of subiculum, while the ventral subiculum (vSub) plays a role in anxiety, stress and emotion. In the present study, we examined the projection of the ventral subiculum to the whole brain in mice by using a modified herpes simplex virus 1 strain H129 with an inserted fluorescent protein gene. In our experiments, the modified H129 transits the primary-order, second-order, and third-order neuronal projections at 36-44, 52-60 and 68-76h after inoculation in mice, respectively. Our data revealed that vSub directly projects to the medial entorhinal cortex, amygdalohippocampal area, anterodorsal thalamic nucleus, medial hypothalamus, supramammillary nucleus, medial septal nucleus and adjacent diagonal band, the connections between median raphe nucleus and interpeduncular nucleus in brain stem, while ventral prefrontal cortex, laterodorsal tegmental nucleus and locus coeruleus receives second-order projections from vSub. Our data would help further understanding the functional connections of vSub with other brain regions.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Tang H,Wu GS,Xie J,He X,Deng K,Wang H,Xu F,Luo HR

doi

10.1016/j.neulet.2016.07.014

subject

Has Abstract

pub_date

2016-08-26 00:00:00

pages

171-179

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(16)30500-6

journal_volume

629

pub_type

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