Abstract:
:The present study investigated the changes in the expression of regulators of G-protein-coupled signaling proteins RGS2, 7 and 8 in gerbil hippocampus to better understand alterations of G-protein-coupled receptors signaling after cerebral ischemia. In situ hybridization revealed a transient, robust early increase in RGS7 mRNA levels in the dentate gyrus after ischemia. RGS8 mRNA expression started to increase at a later time point in the CA3 region but no changes were found for RGS2. Our results show a subtype-, time-, and subregion-specific regulation in mRNA expression of RGS proteins after cerebral ischemia in gerbil hippocampus.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Shelat PB,Coulibaly AP,Wang Q,Sun AY,Sun GY,Simonyi Adoi
10.1016/j.neulet.2006.04.037subject
Has Abstractpub_date
2006-07-31 00:00:00pages
157-61issue
1-2eissn
0304-3940issn
1872-7972pii
S0304-3940(06)00428-9journal_volume
403pub_type
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