Abstract：
:In ten patients with Parkinson's disease (PD) and ten age-matched healthy controls, we applied 15 30-s trains of subthreshold 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor hand area. Ten minutes after rTMS, PD patients showed a significant prolongation of the transcranially evoked silent period (SP) in the contralateral first dorsal interosseus muscle, whereas the SP remained unchanged in healthy subjects. Since the duration of the transcranially evoked SP is a well-established measure of intracortical inhibition, this finding demonstrates that rTMS is capable of inducing a short-term increase in intracortical inhibition in PD. The lack of a prolongation of the SP in healthy controls suggests that PD patients may be particularly susceptible to modulatory effects of rTMS on motocortical inhibition.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Siebner HR,Mentschel C,Auer C,Lehner C,Conrad Bdoi
10.1016/s0304-3940(00)00990-3keywords:
subject
Has Abstractpub_date
2000-04-28 00:00:00pages
147-50issue
3eissn
0304-3940issn
1872-7972pii
S0304394000009903journal_volume
284pub_type
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