Abstract:
:Quantitative in vitro receptor autoradiography was used to examine the effect of acute scopolamine administration on specific binding to components of the N-methyl-D-aspartate (NMDA) receptor complex in four regions of mouse hippocampus. The binding of [3H]glycine to the strychnine-insensitive site was increased 1 h after administration of scopolamine hydrobromide (10 mg/kg) in the ventral dentate gyrus. The study suggests that rapid alterations in strychnine-insensitive glycine binding can occur in response to cholinergic perturbations. Moreover, these data suggest a delicate interaction between cholinergic and glutamatergic projections in the hippocampus.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Deutsch SI,Panchision DM,Rosse RB,Novitzki MR,Miller LP,Mastropaolo Jdoi
10.1016/0304-3940(90)90264-asubject
Has Abstractpub_date
1990-10-02 00:00:00pages
124-7issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(90)90264-Ajournal_volume
118pub_type
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