Sites of origin of corticotropin-releasing factor-like immunoreactive projection fibers to the paraventricular thalamic nucleus in the rat.

Abstract:

:Neurons containing the peptide corticotropin-releasing factor (CRF) are thought to play a pivotal role in orchestrating autonomic and behavioral responses to stress. CRF afferents to the thalamus are almost entirely concentrated in the midline nuclei, especially in the paraventricular thalamic nucleus. In chloral hydrate-anesthetized male Wistar rats, we sought to determine the sites of origin of the CRF projection fibers to the thalamus, employing a combination of retrograde neuronal tracing and immunocytochemistry for CRF. Prethalamic neurons showing CRF immunoreactivity were detected in the continuum formed by the central nucleus of amygdala and the bed nucleus of the stria terminalis. Additional sources of the CRF fibers to the thalamus were also detected in the parabrachial nuclei and ventrolateral medulla.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Otake K,Nakamura Y

doi

10.1016/0304-3940(95)12148-w

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

84-6

issue

1

eissn

0304-3940

issn

1872-7972

pii

030439409512148W

journal_volume

201

pub_type

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