Abstract:
:Neurons containing the peptide corticotropin-releasing factor (CRF) are thought to play a pivotal role in orchestrating autonomic and behavioral responses to stress. CRF afferents to the thalamus are almost entirely concentrated in the midline nuclei, especially in the paraventricular thalamic nucleus. In chloral hydrate-anesthetized male Wistar rats, we sought to determine the sites of origin of the CRF projection fibers to the thalamus, employing a combination of retrograde neuronal tracing and immunocytochemistry for CRF. Prethalamic neurons showing CRF immunoreactivity were detected in the continuum formed by the central nucleus of amygdala and the bed nucleus of the stria terminalis. Additional sources of the CRF fibers to the thalamus were also detected in the parabrachial nuclei and ventrolateral medulla.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Otake K,Nakamura Ydoi
10.1016/0304-3940(95)12148-wsubject
Has Abstractpub_date
1995-12-01 00:00:00pages
84-6issue
1eissn
0304-3940issn
1872-7972pii
030439409512148Wjournal_volume
201pub_type
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journal_title:Neuroscience letters
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