Abstract：
:The clinical efficacy of clozapine in treating schizophrenia may stem from its lack of receptor selectivity. If true, several clozapine-sensitive receptors may be co-expressed by neurons dysfunctional in schizophrenia. To test this hypothesis, neurons from the rat medial prefrontal cortex were acutely isolated and subjected to single cell RT-PCR analysis. The co-ordinated expression of five clozapine-sensitive receptors (D4, m1, 5-HT2a, 5-HT2c, 5-HT7) was examined in interneurons and pyramidal neurons. Profiling of GABAergic interneurons commonly revealed the co-expression of two or more clozapine-sensitive receptor mRNAs. Although co-expression of these receptors was less extensive in pyramidal neurons, it was also commonly found. These results suggest that clozapine's therapeutic effects may be mediated by antagonism of dopaminergic, cholinergic and serotoninergic signaling pathways at the single cell level.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Vysokanov A,Flores-Hernandez J,Surmeier DJdoi
10.1016/s0304-3940(98)00882-9subject
Has Abstractpub_date
1998-12-24 00:00:00pages
179-82issue
3eissn
0304-3940issn
1872-7972pii
S0304394098008829journal_volume
258pub_type
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