Well-maintained responses of acetylcholine release and blood flow in the cerebral cortex to focal electrical stimulation of the nucleus basalis of Meynert in aged rats.

abstract：:Previous studies indicate that the locus coeruleus (LC) can be divided into sub-areas depending upon dominant efferent projection zones. Ascending projections to the forebrain originate within the dorsal half and projections to the spinal cord and the cerebellum course from the ventral half of the LC. Using Sprague-Da...

journal_title：Neuroscience letters

authors： Babstock D,Malsbury CW,Harley CW

更新日期：1997-03-21 00:00:00

abstract：:Previous studies showed that adenosine receptors of the temporal and frontal cortices were not affected in Alzheimer's disease (AD). Here, we assessed the specific binding of [3H]cyclohexyladenosine to adenosine1 (A1) receptors in hippocampus from AD subjects and age-matched controls. By both particulate membrane and ...

journal_title：Neuroscience letters

authors： Kalaria RN,Sromek S,Wilcox BJ,Unnerstall JR

更新日期：1990-10-16 00:00:00

abstract：:It is known that 5HTR2A (rs6311) receptors have high concentration in the cortical layer-5 pyramidal neurons and that these receptors play an important role in the modulation of neurocognitive functions. For example, layer-5 pyramidal neurons mediate cellular level integrative interaction of primary sensory afferent s...

journal_title：Neuroscience letters

authors： Maksimov M,Vaht M,Harro J,Bachmann T

更新日期：2015-01-01 00:00:00

abstract：:Mood stabilizers are a category of medications used in the management of mood disorders. The mood stabilizing properties of lithium were first reported in 1949 by John Cade, and since then it has been considered the first line treatment for bipolar disorder. Despite presenting more differences than similarities, mood ...

journal_title：Neuroscience letters

authors： Pisanu C,Papadima EM,Del Zompo M,Squassina A

更新日期：2018-03-16 00:00:00

abstract：:In anaesthetised cats, antibody microprobes were used to measure the release of immunoreactive calcitonin gene-related peptide (irCGRP) in the lumbar dorsal horn during stimulation of non-nociceptive or nociceptive primary afferent fibres. Release of irCGRP was detected in the substantia gelatinosa, where immunostaini...

journal_title：Neuroscience letters

authors： Morton CR,Hutchison WD

更新日期：1990-09-18 00:00:00

abstract：:To investigate the actions of glucocorticoids (GCs) on astrocyte functions, interactions of dexamethasone and immediate early genes (IEGs) were studied in cell cultures of rat cerebral cortical astrocytes. Vasoactive intestinal peptide (VIP) induces rapid c-fos mRNA expression and morphological changes (stellation) in...

journal_title：Neuroscience letters

authors： Hisanaga K,Sagar SM,Koistinaho J,Hicks KJ,Sharp FR

更新日期：1993-06-25 00:00:00

abstract：:Hypoxia is one of the important physiological stimuli that are often associated with a variety of pathological states such as ischemia, respiratory diseases, and tumorigenesis. In the central nervous system, hypoxia that is accompanied by cerebral ischemia not only causes neuronal cell injury, but may also induce path...

journal_title：Neuroscience letters

authors： Suk K

更新日期：2004-08-12 00:00:00

abstract：:Mounting evidence suggests a chronic pro-inflammatory state in individuals with bipolar disorder (BD). Stress exposure is known to exacerbate several inflammatory conditions as well as psychiatric disorders. Here, we analyzed plasma levels of pro-inflammatory cytokines and their soluble receptors to realistic acute ps...

journal_title：Neuroscience letters

authors： Wieck A,Grassi-Oliveira R,do Prado CH,Rizzo LB,de Oliveira AS,Kommers-Molina J,Viola TW,Marciano Vieira EL,Teixeira AL,Bauer ME

更新日期：2014-09-19 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA) receptors were expressed in Xenopus oocytes from injected mRNA. The presence of an alternatively-spliced insertion encoding 21 amino acids at the N-terminus of the NMDAR1 (NR1(111)) subunit, made homomeric assemblies of the receptor more sensitive to ketamine and MK-801 than receptors assem...

journal_title：Neuroscience letters

authors： Rodríguez-Paz JM,Anantharam V,Treistman SN

更新日期：1995-05-12 00:00:00

abstract：:Telmisartan is an angiotensin II type 1 receptor blocker and partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). Here, we investigated the protective capacity of telmisartan against high glucose (HG)-elicited oxidative damage in PC12 cells. The activity of lactate dehydrogenase (LDH), NADPH o...

journal_title：Neuroscience letters

authors： Eslami H,Sharifi AM,Rahimi H,Rahati M

更新日期：2014-01-13 00:00:00

abstract：:During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5 degrees C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos in...

journal_title：Neuroscience letters

authors： Bitting L,Sutin EL,Watson FL,Leard LE,O'Hara BF,Heller HC,Kilduff TS

更新日期：1994-01-03 00:00:00

abstract：:Dysregulated brain glucose metabolism and lactate accumulation are seen following traumatic brain injury (TBI). The underlying molecular mechanism is poorly understood. Pyruvate dehydrogenase (PDH), the rate-limiting enzyme coupling cytosolic glycolysis to mitochondrial citric acid cycle, plays a critical role in main...

journal_title：Neuroscience letters

authors： Xing G,Ren M,Watson WD,O'Neill JT,Verma A

更新日期：2009-04-17 00:00:00

abstract：:Dissociable circadian rhythms of sleep and body temperature in primates are thought to be regulated by independent oscillators whereas the uncoupling of circadian rhythms has not been well described in other mammals. Therefore, we made simultaneous recordings of non-rapid-eye-movement-sleep (NREMS), rapid-eye-movement...

journal_title：Neuroscience letters

authors： Ikeda M,Sagara M,Inoué S

更新日期：2000-02-04 00:00:00

abstract：:The role of dopamine (DA) in the rat locus coeruleus (LC) was investigated by determining the levels of 3,4-dihydroxyphenylacetic acid (DOPAC), DA and noradrenaline (NA) in the LC after pharmacological treatments by pargyline, haloperidol, 6-hydroxydopamine (6-OHDA) and desmethylimipramine (DMI). The DA, DOPAC and NA ...

journal_title：Neuroscience letters

authors： Milon H,McRae-Degueurce A

更新日期：1982-06-30 00:00:00

abstract：:The existence of long-term effects of dark-rearing on visuo-motor coordination is still controversial. In this study 2 dark-reared (DR) cats were trained, after 5-6 years of recovery, to perform a reaching movement towards a stationary or a moving target. The accuracy, and the reaction and movement times were evaluate...

journal_title：Neuroscience letters

authors： Fabre-Thorpe M,Levesque F,Gary-Bobo E

更新日期：1990-10-16 00:00:00

abstract：:Evidence suggests that high peripheral beta-amyloid (Abeta)(1-40) levels and low ratios of Abeta(1-42)/Abeta(1-40) are associated with increased risk for Alzheimer's disease (AD). In this cross-sectional design, serum and plasma samples from 67 AD patients and 146 controls (similar in age and gender) were evaluated us...

journal_title：Neuroscience letters

authors： Abdullah L,Paris D,Luis C,Quadros A,Parrish J,Valdes L,Keegan AP,Mathura V,Crawford F,Mullan M

更新日期：2007-11-27 00:00:00

abstract：:The circadian rhythm and dehydration-induced response of vasopressin (AVP) levels in rat cerebrospinal fluid (CSF) were studied after lesions had been made in the paraventricular (PVN) and suprachiasmatic (SCN) nuclei. The rhythmic fluctuation of AVP levels in CSF was abolished after SCN lesions, whereas lesions of th...

journal_title：Neuroscience letters

authors： Jolkkonen J,Tuomisto L,van Wimersma Greidanus TB,Riekkinen PJ

更新日期：1988-03-31 00:00:00

abstract：:The existence of neurons expressing preprogalanin mRNA in the monkey hippocampal formation was demonstrated using in situ hybridization of a radio-labelled cRNA probe transcribed from human preprogalanin cDNA. Specific hybridization occurred in neurons of the hilus of the dentate gyrus, fields CA1-3 in Ammon's horn, s...

journal_title：Neuroscience letters

authors： Evans HF,Huntley GW,Morrison JH,Shine J,Paxinos G

更新日期：1992-11-09 00:00:00

abstract：:The level of endogenous nerve growth factor (NGF) in rat sciatic nerve was determined using a highly sensitive two-site enzyme immunoassay. After crushing this nerve NGF accumulated linearly distal to the crush during the first 12 h to reach levels 13-fold higher than in the uncrushed contralateral side. In contrast, ...

journal_title：Neuroscience letters

authors： Korsching S,Thoenen H

更新日期：1983-08-19 00:00:00

abstract：:Sertindole has been marketed and offered daily clinical practice only for 9 months in our country, so no data has been its QTc prolongation potential. In the present study, we performed a clinical trial to investigate the effects of sertindole on QTc in patients with schizophrenia. The study comprised 21 patients with...

journal_title：Neuroscience letters

authors： Atmaca M,Yavuzkir M,Mermi O,Topuz M,Kanmaz E,Tezcan E

更新日期：2008-09-05 00:00:00

abstract：:Nitric oxide (NO) mediates cell-cell signalling in the brain and stimulates cyclic GMP (cGMP) production in target cells. We have used NADPH-diaphorase (reduced nicotinamide adenine dinucleotide phosphate-diaphorase) histochemistry to identify NO-producing neurones and cGMP immunohistochemistry to locate the targets o...

journal_title：Neuroscience letters

authors： Southam E,Morris R,Garthwaite J

更新日期：1992-03-30 00:00:00

abstract：:The periaqueductal gray (PAG) is involved in motor activities, such as movements of the neck, back and hind limbs, cardiovascular regulation, micturition, vocalization, and mating behavior, as well as in nociception control. To accomplish these functions the PAG uses information from other parts of the limbic system, ...

journal_title：Neuroscience letters

authors： Mouton LJ,VanderHorst VG,Holstege G

更新日期：1997-11-28 00:00:00

abstract：:Parkinson's disease (PD) is a multifactorial disease caused by both genetic and environmental factors. Alpha-synuclein is of particular interest in PD since it is a major component of Lewy bodies and mutations in the alpha-synuclein gene were identified in familial PD. Oxidative stress and proteasomal dysfunction are ...

journal_title：Neuroscience letters

authors： Lev N,Melamed E,Offen D

更新日期：2006-05-15 00:00:00

abstract：:Survivors of bacterial meningitis frequently suffer from long-term sequelae, particularly from learning and memory deficits. For this reason, spatial memory and learning was studied in a mouse model of ceftriaxone-treated Streptococcus pneumoniae meningitis. Persistent deficits of spatial learning despite normal motor...

journal_title：Neuroscience letters

authors： Wellmer A,Noeske C,Gerber J,Munzel U,Nau R

更新日期：2000-12-22 00:00:00

abstract：:Previous studies have observed increased tachykinin NK(1) receptor immunoreactivity (NK(1)-IR) in the prefrontal cortex in subjects with schizophrenia. Since the subjects were medicated the possibility of a treatment effect could not be excluded. Thus, the present study was undertaken to determine the effect of chroni...

journal_title：Neuroscience letters

authors： Tooney PA,Anderson WB,Lynch-Frame A,Chahl LA

更新日期：2005-07-22 00:00:00

abstract：:Recent studies have suggested the involvement of some metabolic hormones in memory formation and synaptic plasticity. Insulin dysfunction is known as an essential process in the pathogenesis of sporadic Alzheimer's disease (AD). In this study we examined whether adiponectin (ADN), as an insulin-sensitizing adipokine, ...

journal_title：Neuroscience letters

authors： Pousti F,Ahmadi R,Mirahmadi F,Hosseinmardi N,Rohampour K

更新日期：2018-01-01 00:00:00

abstract：:[3H] Overflow evoked by 5 min supramaximal preganglionic stimulation at 1 pps has been studied in isolated guinea pig superior cervical ganglion preparations preincubated with [3H]choline. At 15 microM norepinephrine (NE) reduced both the [3H]choline overflow and endogenous acetylcholine release by 59.4 and 54.1% resp...

journal_title：Neuroscience letters

authors： Belluzzi O,Travagli RA,Bonifazzi C,Perri V

更新日期：1987-01-02 00:00:00

abstract：:Numerous studies have provided evidence that physical activity promotes cortical plasticity in the adult brain and in turn facilitates learning. However, until now, the effect of simultaneous physical activity (e.g. bicycling) on learning performance has not been investigated systematically. The current study aims at ...

journal_title：Neuroscience letters

authors： Schmidt-Kassow M,Kulka A,Gunter TC,Rothermich K,Kotz SA

更新日期：2010-09-20 00:00:00

abstract：:Pain-related evoked potentials (PREP) is an established electrophysiological method to evaluate the signal transmission of electrically stimulated A-delta fibres. Although prerequisite for its clinical use, test-retest-reliability and side-to-side differences of bilateral stimulation in healthy subjects have not been ...

journal_title：Neuroscience letters

authors： Özgül ÖS,Maier C,Enax-Krumova EK,Vollert J,Fischer M,Tegenthoff M,Höffken O

更新日期：2017-04-24 00:00:00

abstract：:Intolerance of uncertainty (IU), or the increased affective response to situations with uncertain outcomes, is an important component process of anxiety disorders. Increased IU is observed in panic disorder (PD), obsessive compulsive disorder (OCD) and generalized anxiety disorder (GAD), and is thought to relate to dy...

journal_title：Neuroscience letters

authors： Simmons A,Matthews SC,Paulus MP,Stein MB

更新日期：2008-01-10 00:00:00