2,4,5-Trihydroxyphenylalanine (6-hydroxy-dopa) displaces [3H]AMPA binding in rat striatum.

abstract：:We have investigated the effect of histamine (HA) on spontaneous firing of dopaminergic (DA) and GABAergic neurons in the substantia nigra (SN) and the ventral tegmental area (VTA) of the rat in vitro. Single-unit extracellular recordings were obtained and drugs were bath applied. In both regions application of HA (10...

journal_title：Neuroscience letters

authors： Korotkova TM,Haas HL,Brown RE

更新日期：2002-03-08 00:00:00

abstract：:Drebrin has been known to act on actin filaments at dendritic spines to cause morphological change, and might be related to the plasticity of synaptic transmission. In the present study, changes of drebrin were examined immunohistochemically in the spinal motoneurons of rats following unilateral sciatic nerve transect...

journal_title：Neuroscience letters

authors： Kobayashi S,Shirao T,Sasaki T

更新日期：2001-10-05 00:00:00

abstract：:Somatostatin and several analogues were injected into rat striatum and their effects on dopamine, serotonin and their metabolites were examined at 1 h. Somatostatin induced a dose-dependent increase in dopamine turnover in the ipsilateral striatum accompanied by a reduction in turnover on the contralateral side. There...

journal_title：Neuroscience letters

authors： Beal MF,Martin JB

更新日期：1984-02-24 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA) is an illegal drug that can induce life-threatening hyperthermia. No effective pharmacological treatment for MDMA-induced hyperthermia has yet been established. We investigated the effects of memantine, a non-competitive N-methyl-D-aspartate (NMDA)-type glutamate receptor antag...

journal_title：Neuroscience letters

authors： Nisijima K,Kuboshima K,Shioda K,Yoshino T,Iwamura T,Kato S

更新日期：2012-12-07 00:00:00

abstract：:The binding of radioiodinated omega-conotoxin GVIA, a probable Ca channel antagonist, to synaptic plasma membranes of rat brain was examined. Two kinds of specific binding sites were found with apparent dissociation constants of 10 pM and 0.5 nM and maximum binding capacities of 0.5 and 3.4 pmol/mg prot., respectively...

journal_title：Neuroscience letters

authors： Abe T,Koyano K,Saisu H,Nishiuchi Y,Sakakibara S

更新日期：1986-11-11 00:00:00

abstract：:The effects of severe hypoglycemia on perforant path-evoked field potentials were examined in the rat hippocampus. Although a complete loss of this response was noted when blood glucose concentration fell below 1 mM, this occurred before cessation of electroencephalogram (EEG) activity. Both spontaneous and evoked res...

journal_title：Neuroscience letters

authors： Butcher SP,Jacobson I,Sandberg M,Hagberg H,Hamberger A

更新日期：1987-05-19 00:00:00

abstract：:The effects have been investigated of anesthetic and convulsant barbiturates on the spontaneous and potassium-stimulated efflux of [3H]D-aspartate from rat cortex minislices. In concentrations (100 microM) which have previously been shown to alter calcium ATPase activity in synaptosomes, anaesthetic barbiturates depre...

journal_title：Neuroscience letters

authors： Willow M,Bornstein JC,Johnston GA

更新日期：1980-06-01 00:00:00

abstract：:The intracerebroventricular injection of the mast cell degranulator, compound 48/80 (C48/80, 10 micrograms/kg), produced a marked behavioural syndrome in rats which included head and body shakes, paw tremor, excessive grooming, unusual posture and gait, mild diarrhoea, piloerection, extreme agitation and irritability ...

journal_title：Neuroscience letters

authors： Lewis SJ,Quinn MJ,Fennessy MR,Jarrott B

更新日期：1986-03-28 00:00:00

abstract：:Activated microglia surround degenerating substantia nigra neurons in Parkinson's disease (PD). Such microglia produce high levels of interleukin-1 beta (IL-1 beta) and interleukin-1 alpha (IL-1 alpha). T and C alleles exist for the IL-1 beta-511 regulatory region as well as for the IL-1 alpha-889 regulatory region. T...

journal_title：Neuroscience letters

authors： McGeer PL,Yasojima K,McGeer EG

更新日期：2002-06-21 00:00:00

abstract：:Microelectrode recordings from the somata of rat dorsal root ganglion (DRG) cells were used to correlate their electrophysiological characteristics with sensitivity to locally applied capsaicin. Of the 80 cells tested, 17 responded to capsaicin by a rapid depolarization. These cells had low axonal conduction velocitie...

journal_title：Neuroscience letters

authors： Heyman I,Rang HP

更新日期：1985-05-01 00:00:00

abstract：:The present study was aimed at determining whether human recombinant hepatocyte growth factor (HGF) ameliorates cerebral edema induced by microsphere embolism (ME). Rats were injected with 700 microspheres (48 microm in diameter). Continuous administration of HGF at 13 microg/3 days/animal into the right ventricle was...

journal_title：Neuroscience letters

authors： Takeo S,Takagi N,Takagi K,Date I,Ishida K,Besshoh S,Nakamura T,Tanonaka K

更新日期：2008-12-19 00:00:00

abstract：:The effect of capsaicin was studied on non-cholinergic inhibitory postsynaptic currents (IPSC). The experiments were performed on an identified snail neurone using the single electrode voltage-clamp technique. The IPSC decayed with a bi-exponential time course. Capsaicin (200 microM) reversibly blocked both components...

journal_title：Neuroscience letters

authors： Erdélyi L,Such G

更新日期：1984-03-09 00:00:00

abstract：:Up-regulation of neuronal cyclooxygenase-2 (COX-2) and the elevation in prostaglandin E(2) (PGE(2)) have been reported to occur after cerebral ischemic insult. To evaluate whether the COX-2 reaction product PGE(2) is directly related to induction of apoptosis in neuronal cells, the effect of PGE(2) on cell viability w...

journal_title：Neuroscience letters

authors： Takadera T,Yumoto H,Tozuka Y,Ohyashiki T

更新日期：2002-01-11 00:00:00

abstract：:Neuroinflammation can lead to either damage of astrocytes or astrogliosis. Astrocyte loss may be caused by cytotoxic T cells as seen in Rasmussen encephalitis, auto-antibodies such as in neuromyelitis optica (aquaporin-4 antibodies), or cytokines such as TNF-α in major depressive disorder. Interleukins-1 and -6 appear...

journal_title：Neuroscience letters

authors： Hostenbach S,Cambron M,D'haeseleer M,Kooijman R,De Keyser J

更新日期：2014-04-17 00:00:00

abstract：:Morphine and other opioids have direct analgesic actions in the spinal cord and chronic spinal administration of opioid agonists is used clinically in patients suffering from severe, chronic pain. Neuropathic pain resulting from peripheral nerve injury is often less sensitive to opioid therapy than other forms of chro...

journal_title：Neuroscience letters

authors： Stone LS,Vulchanova L,Riedl MS,Williams FG,Wilcox GL,Elde R

更新日期：2004-05-06 00:00:00

abstract：:Pineal serotonin (5-HT), 5-hydroxyindole-acetic acid (5-HIAA), norepinephrine (NE), epinephrine (E) and adrenal corticosterone, NE and E contents were measured spectrofluorometrically 5, 15, 30 and 60 min after insulin treatment to induce hypoglycemic stress. In the pineal gland, hypoglycemic stress caused dramatic de...

journal_title：Neuroscience letters

authors： Mahata SK

更新日期：1991-01-02 00:00:00

abstract：:Herpes simplex virus encephalitis (HSVE) causes elevated morbidity and mortality despite antiviral treatment. Virus-independent mechanisms may perpetuate brain damage. Matrix metalloproteinases (MMPs) target extracellular matrix components. This study describes the protein and mRNA expression of MMP2 and MMP9 in exper...

journal_title：Neuroscience letters

authors： Martínez-Torres FJ,Wagner S,Haas J,Kehm R,Sellner J,Hacke W,Meyding-Lamadé U

更新日期：2004-09-30 00:00:00

abstract：:We identified a 45-kDa protein by 2D electrophoresis that was enhanced following pentylenetetrazol (PTZ)-mediated seizures. Mass-spectrography of this protein revealed the beta subunit of Ca2+/calmodulin-dependent protein kinase II (CaMKIIbeta), although no evidence for increase in bulk CaMKIIbeta transcripts was obta...

journal_title：Neuroscience letters

authors： Matsu-ura T,Nakadai T,Oda Y,Nagasu T,Mikoshiba K,Tamura TA

更新日期：2002-04-12 00:00:00

abstract：:The content of two neuropeptides, somatostatin (SRIF) and neuropeptide Y (NPY) has been determined in two cerebral cortical areas of Alzheimer's disease brain and in age-matched control brains. The content of SRIF-like immunoreactivity (SRIF-LI) was found to be decreased in Alzheimer temporal cortex (Brodmann area 21)...

journal_title：Neuroscience letters

authors： Dawbarn D,Rossor MN,Mountjoy CQ,Roth M,Emson PC

更新日期：1986-09-25 00:00:00

abstract：:Previous in vitro experiments have indicated that neuronal GABA aminotransferase (GABA-T) differs from extraneuronal GABA-T in sensitivity to certain enzyme inhibitors, including the antiepileptic drug valproate (VPA). In the present experiments, it was studied if GABA-T activity in whole tissue and synaptosomes prepa...

journal_title：Neuroscience letters

authors： Löscher W

更新日期：1993-10-01 00:00:00

abstract：:Different responses evoked by stimulation of contralateral hippocampus at various levels are examined in new-born rabbits up to 1 month of age. Commissural fibres coming from the CA3-CA4 reach the contralateral regio superior (CA1) essentially at the st. oriens levels. CA1 responses elicited by stimulation of the cont...

journal_title：Neuroscience letters

authors： Thomson MA

更新日期：1979-02-01 00:00:00

abstract：:Astrocytes in the CNS produce inflammatory mediators in response to several stimuli and cytokines. Here we investigated the in vitro effect of leptin on inducible nitric oxide synthase (iNOS) expression in a glioma cell line (C6). After hormone stimulation, culture media were analysed for accumulated stable oxidation ...

journal_title：Neuroscience letters

authors： Mattace Raso G,Esposito E,Iacono A,Pacilio M,Coppola A,Bianco G,Diano S,Di Carlo R,Meli R

更新日期：2006-03-27 00:00:00

abstract：:Telmisartan is an angiotensin II type 1 receptor blocker and partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). Here, we investigated the protective capacity of telmisartan against high glucose (HG)-elicited oxidative damage in PC12 cells. The activity of lactate dehydrogenase (LDH), NADPH o...

journal_title：Neuroscience letters

authors： Eslami H,Sharifi AM,Rahimi H,Rahati M

更新日期：2014-01-13 00:00:00

abstract：:Immunoelectron microscopy combined with a retrograde tracing technique was carried out to examine the synaptic interaction between neuropeptide Y (NPY)-like immunoreactive (LI) axon terminals and spinal motoneurons innervating bulbocavernosus muscles. Cell bodies and proximal dendrites of these motoneurons were freque...

journal_title：Neuroscience letters

authors： Kawano M,Sugita O,Inagaki S,Furuyama T,Takagi H

更新日期：1993-04-02 00:00:00

abstract：:Although dopaminergic neurons are thought to exist in the lateral olivocochlear efferent system and modulate the afferent nerve activity, the distribution of dopamine (DA) receptor subtypes is still obscure. In the present study, we investigated the localization of five subtypes of DA receptor (D1-5) by immunocytochem...

journal_title：Neuroscience letters

authors： Inoue T,Matsubara A,Maruya S,Yamamoto Y,Namba A,Sasaki A,Shinkawa H

更新日期：2006-05-22 00:00:00

abstract：:Functional neuroimaging data have shown that mental calculation involves fronto-parietal areas that are composed of different subsystems shared with other cognitive functions such as working memory and language. Event-related potential (ERP) analysis has also indicated sequential information changes during the calcula...

journal_title：Neuroscience letters

authors： Ku Y,Hong B,Gao X,Gao S

更新日期：2010-03-12 00:00:00

abstract：:Activation of the μ-opioid receptor (MOR) and noradrenaline reuptake inhibition (NRI) are well recognized as analgesic principles in acute and chronic pain indications. The novel analgesic tapentadol combines MOR agonism and NRI in a single molecule. The present study used OPRM1 (MOR) knockout (KO) mice to determine t...

journal_title：Neuroscience letters

authors： Kögel B,De Vry J,Tzschentke TM,Christoph T

更新日期：2011-03-17 00:00:00

abstract：:Whole-cell and single channel recordings were used to characterize an intermediate conductance calcium-activated potassium (KCa) channel in sensory neurons of the nodose ganglion. From a -80 mV holding potential, the total outward current in these neurons was increased when extracellular calcium was raised from 0.02 t...

journal_title：Neuroscience letters

authors： Hay M,Kunze DL

更新日期：1994-02-14 00:00:00

abstract：:Neuraxial analgesia is often provided using a mixture of local anesthetics and opioids. This combination of agents provides better pain relief and is generally associated with fewer side effects than when either drug is given alone. Local anesthetics have been shown to alter signaling of other G protein-coupled recept...

journal_title：Neuroscience letters

authors： Komai H,McDowell TS

更新日期：2007-05-18 00:00:00

abstract：:The present study was designed to test the hypothesis that alpha-tocopherol (Vit. E) and pyrrolidine dithiocarbamate (PDTC) might exert direct effects on alcohol-induced contractions of canine basilar cerebral arteries. After precontraction of arterial ring segments with ethanol, PDTC (10(-8)-10(-6) M) and Vit. E (10(...

journal_title：Neuroscience letters

authors： Li W,Zheng T,Altura BT,Altura BM

更新日期：2001-03-30 00:00:00