Abstract：
:We have investigated the effect of histamine (HA) on spontaneous firing of dopaminergic (DA) and GABAergic neurons in the substantia nigra (SN) and the ventral tegmental area (VTA) of the rat in vitro. Single-unit extracellular recordings were obtained and drugs were bath applied. In both regions application of HA (10 and 100 microM) did not affect the firing frequency of DAergic cells, but increased the firing of GABAergic neurons. The histamine-induced excitation was blocked by the H(1) receptor antagonist mepyramine (1 microM), but was unaffected by application of the H(2) antagonist cimetidine (50 microM) or the H(3) antagonist thioperamide (10 microM). Our results suggest that histamine does not directly inhibit dopaminergic neurons in SN and VTA, but rather that this inhibition is mediated through histamine-induced excitation of GABAergic neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Korotkova TM,Haas HL,Brown REdoi
10.1016/s0304-3940(02)00050-2keywords:
subject
Has Abstractpub_date
2002-03-08 00:00:00pages
133-6issue
3eissn
0304-3940issn
1872-7972pii
S0304394002000502journal_volume
320pub_type
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