The effect of pentylenetetrazole-kindling on the extracellular glutamate and taurine levels in the frontal cortex of rats.

Abstract:

:We studied the extracellular concentration of glutamate and taurine in the frontal cortex of freely-moving pentylenetetrazole (PTZ) kindled rats using an in vivo microdialysis. A significant and sustained increase in the glutamate level was observed in the kindled rats, in contrast, a slight and delayed increase was observed in the non-kindled rats when the same grade seizure was induced by PTZ. The convulsive dose of PTZ administration caused a decrease in taurine levels in the controls, however, no significant changes were found in the kindled rats.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Li Z,Yamamoto Y,Morimoto T,Ono J,Okada S,Yamatodani A

doi

10.1016/s0304-3940(00)00838-7

keywords:

subject

Has Abstract

pub_date

2000-03-17 00:00:00

pages

117-9

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

S0304394000008387

journal_volume

282

pub_type

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