Abstract:
:We studied the extracellular concentration of glutamate and taurine in the frontal cortex of freely-moving pentylenetetrazole (PTZ) kindled rats using an in vivo microdialysis. A significant and sustained increase in the glutamate level was observed in the kindled rats, in contrast, a slight and delayed increase was observed in the non-kindled rats when the same grade seizure was induced by PTZ. The convulsive dose of PTZ administration caused a decrease in taurine levels in the controls, however, no significant changes were found in the kindled rats.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Li Z,Yamamoto Y,Morimoto T,Ono J,Okada S,Yamatodani Adoi
10.1016/s0304-3940(00)00838-7keywords:
subject
Has Abstractpub_date
2000-03-17 00:00:00pages
117-9issue
1-2eissn
0304-3940issn
1872-7972pii
S0304394000008387journal_volume
282pub_type
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