Different increase in C-fibre evoked responses after nociceptive conditioning stimulation in sham-operated and neuropathic rats.

abstract：:N-omega-[18F]fluoroethylketanserin ([18F]FEK), an 18F-labeled analogue of the serotonin S2 antagonist ketanserin, was evaluated for use with positron emission tomography (PET). PET imaging of a baboon brain following injection of [18F]FEK indicated that the fluorinated ligand rapidly localized in vivo within S2 recept...

journal_title：Neuroscience letters

authors： Moerlein SM,Perlmutter JS

更新日期：1991-02-11 00:00:00

abstract：:The association of alpha-synuclein (alpha-syn) neuropathology with Parkinson's disease (PD) and several related disorders has led to an intense research effort to develop cerebrospinal fluid (CSF)- or blood-based alpha-syn biomarkers for these types of diseases. Recent studies show that alpha-syn is present in CSF and...

journal_title：Neuroscience letters

authors： Ohrfelt A,Grognet P,Andreasen N,Wallin A,Vanmechelen E,Blennow K,Zetterberg H

更新日期：2009-02-06 00:00:00

abstract：:Advanced glycation end products (AGEs) in the brain were immunohistochemically examined in Alzheimer's disease (AD) and aging using anti-AGE antibody recognizing mainly carboxymethyllysine. AGE positive staining diffusely located in the neuronal perikarya of hippocampus and parahippocampus in AD and aged brains withou...

journal_title：Neuroscience letters

authors： Takedo A,Yasuda T,Miyata T,Mizuno K,Li M,Yoneyama S,Horie K,Maeda K,Sobue G

更新日期：1996-12-27 00:00:00

abstract：:We investigated whether the perceived roughness of the end of a tool is influenced by the texture of the handle used to hold it. Participants rated the roughness of the ends (caps) of a series of tools by rubbing them along their forearm, and indicated the perceived roughness of the tool's cap by means of an anchored ...

journal_title：Neuroscience letters

authors： Zampini M,Mawhinney S,Spence C

更新日期：2006-06-12 00:00:00

abstract：:Estrogen not only modulates nigrostriatal function but also developmental processes in the striatum. Recently, we have demonstrated the presence of the estrogen-synthesizing enzyme aromatase in the developing mouse striatum. This study is concerned with the expression of estrogen receptor-alpha/beta (ER) mRNA in the d...

journal_title：Neuroscience letters

authors： Küppers E,Beyer C

更新日期：1999-12-03 00:00:00

abstract：:Preterm infants undergo several painful procedures during their stay in neonatal intensive care units. Previous studies suggest that early painful experiences may have an impact on brain development. Here, we used an animal model to investigate the effect of neonatal pain on the generation of new neurons in the dentat...

journal_title：Neuroscience letters

authors： Leslie AT,Akers KG,Martinez-Canabal A,Mello LE,Covolan L,Guinsburg R

更新日期：2011-08-26 00:00:00

abstract：:We studied the influence of caffeine treatment (50 mg/kg for 3 doses) on catecholamine utilization and adrenergic receptor binding in female rats. Caffeine enhanced the reduction in forebrain norepinephrine levels following alpha-methyl-p-tyrosine without altering the reduction in dopamine levels. Caffeine reduced the...

journal_title：Neuroscience letters

authors： Goldberg MR,Curatolo PW,Tung CS,Robertson D

更新日期：1982-07-20 00:00:00

abstract：:The mechanism underlying the over-recovery of an M-type potassium current following the washout of muscarine (20 microM) has been examined. Whole-cell recordings were made from single neurons dissociated from bullfrog sympathetic ganglia. During over-recovery, the maximum M-conductance decreased by about 2.8 nS while ...

journal_title：Neuroscience letters

authors： Tokimasa T,Simmons MA,Schneider CR,Akasu T

更新日期：1996-03-29 00:00:00

abstract：:Secretion of alpha-melanophore-stimulating hormone (alpha-MSH) from the neuroendocrine melanotrope cells in the intermediate lobe of the pituitary gland of the clawed frog Xenopus laevis is regulated by various inhibitory, stimulatory and autocrine factors. The neuropeptide sauvagine stimulates alpha-MSH secretion by ...

journal_title：Neuroscience letters

authors： van den Hurk MJ,Jenks BG,Roubos EW,Scheenen WJ

更新日期：2005-03-29 00:00:00

abstract：:Excitotoxin lesion of nucleus basalis with kainate or ibotenate results in degeneration of cholinergic neurones and a subsequent cholinergic deficit in cerebral cortex ipsilateral to the lesion. This lesion is accompanied by a massive increase in ornithine decarboxylase (ODC) activity in ipsilateral cortex, which was ...

journal_title：Neuroscience letters

authors： Wood H,de Belleroche J

更新日期：1990-03-26 00:00:00

abstract：:Post-mortem brain tissue from 15 patients dying with a diagnosis of senile dementia of Alzheimer type (SDAT) was compared with tissue obtained from 16 control patients at routine post-mortem. A significant fall in choline acetyltransferase (ChAT) activity was observed in the cortex, hippocampus and amygdala of the SDA...

journal_title：Neuroscience letters

authors： Rossor MN,Emson PC,Mountjoy CQ,Roth M,Iversen LL

更新日期：1980-12-01 00:00:00

abstract：:In guinea pig hippocampal slices, 4-aminopyridine (4-AP) in concentrations of 100-500 microM reduced the adaptation of CA3 pyramidal neurons to depolarizing stimuli, resulting in a prolongation of repetitive firing during injection of long-lasting depolarizing currents. Concurrently, there was a decrease in the 'sag' ...

journal_title：Neuroscience letters

authors： Matsuda Y,Yoshida S,Fujimura K,Nakamura M

更新日期：1986-04-24 00:00:00

abstract：:A marked depression of evoked CA1 potentials was observed with the nucleotide analogues a,b-methylene ADP (AOPCP) and adenylimido-diphosphate (AIP) and with 2'-adenosine monophosphate (2'-AMP). While the depression elicited by 5'-nucleotides was completely antagonized by the action of adenosine deaminase, AOPCP and 2'...

journal_title：Neuroscience letters

authors： Lee KS,Schubert P,Emmert H,Kreutzberg GW

更新日期：1981-05-29 00:00:00

abstract：:Single electrode voltage-clamp recording from CA3 neurons in guinea pig hippocampal slices was applied to study effects of a new GABAB antagonist, CGP 55845A, on (-)baclofen (IBac)- or gamma-aminobutyric acid (IGABA)-induced potassium (K)-currents and on inhibitory postsynaptic K-currents (K-IPSCs) recorded in the pre...

journal_title：Neuroscience letters

authors： Jarolimek W,Demmelhuber J,Bijak M,Misgeld U

更新日期：1993-05-14 00:00:00

abstract：:The effects induced on the discharge of subthalamic spontaneously active neurons by inhibiting the enzyme nitric oxide synthase was studied in two groups of urethane-anesthetized rats. In the first group of animals (n = 10), the activity of subthalamic single units was recorded before and after the systemic administra...

journal_title：Neuroscience letters

authors： Sardo P,Ferraro G,Carletti F,D'Agostino S,La Grutta V

更新日期：2006-04-03 00:00:00

abstract：:The contribution of NMDA receptors to neuronal hyperexcitability following in vitro ethanol withdrawal was examined using afterdischarges (ADs) in rat dentate gyrus as a model system. ADs were evoked by high frequency stimuli and blocked by N-methyl-D-aspartate (NMDA) receptor antagonists. Ethanol (75 mM) inhibited AD...

journal_title：Neuroscience letters

authors： Morrisett RA

更新日期：1994-02-14 00:00:00

abstract：:In the present study we sought to investigate the signal transduction mechanisms that underlie the alpha2-adrenergic receptor (AR)-induced, subtype-specific neuronal differentiation of PC12 cells. Alpha2-ARs induced NF-kappaB transcriptional activity and p21(waf-1) gene transcription in the same subtype-specific manne...

journal_title：Neuroscience letters

authors： Lymperopoulos A,Karkoulias G,Koch WJ,Flordellis CS

更新日期：2006-07-24 00:00:00

abstract：:Basal serotonin (5-HT) release, measured in the presence of imipramine, was significantly reduced in slices of hippocampus, n. accumbens and frontal cortex from rats subjected to forced swim test and chronic isolation. Only in the hippocampus, in the two animal models of depression, K-stimulated release was increased....

journal_title：Neuroscience letters

authors： Jaffe EH,De Frias V,Ibarra C

更新日期：1993-11-12 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor blocker 2-amino-5-phosphonovaleric acid [+/-)-2-APV) and kynurenic acid both suppressed spontaneous epileptiform burst discharges in the CA3 region of rat hippocampal slices. When the bursts were induced by perfusion with magnesium-free medium (+/-)-2-APV was the more potent in...

journal_title：Neuroscience letters

authors： Stone TW

更新日期：1988-01-22 00:00:00

abstract：:It is well established that the reinforcing effect of drugs of abuse is linked to the mesolimbic dopamine (DA) system. Morphine produces an increase in DA release in the brain, which may provide positive reinforcement contributing to the development of motivational aspects of drug-seeking and maintenance behavior. Sev...

journal_title：Neuroscience letters

authors： Yoon SS,Lee BH,Kim HS,Choi KH,Yun J,Jang EY,Shim I,Kim JA,Kim MR,Yang CH

更新日期：2007-11-20 00:00:00

abstract：:Traumatic spinal cord injury (SCI) is a devastating condition of CNS which leads to loss of sensory as well as motor functions. Secondary damage after SCI initiates cascade of events that creates an inhibitory milieu for axonal growth and repair. Combinatorial therapies are the hope to attenuate secondary injury progr...

journal_title：Neuroscience letters

authors： Bhattacharyya S,Dinda A,Vishnubhatla S,Anwar MF,Jain S

更新日期：2021-01-10 00:00:00

abstract：:Triazolam can shift the phase of circadian rhythms in hamsters recorded in constant light or dark. This effect is apparently mediated by physical activity stimulated by the drug. We examined whether triazolam can shift the phase of circadian rhythms in a diurnal primate, the squirrel monkey, that is sedated by triazol...

journal_title：Neuroscience letters

authors： Mistlberger RE,Houpt TA,Moore-Ede MC

更新日期：1991-03-11 00:00:00

abstract：:Infection of the snail Lymnaea stagnalis with the schistosome parasite Trichobilharzia ocellata results in inhibition of reproduction and in giant growth. Parasite-related effects on the neuroendocrine centres that control these processes were studied electrophysiologically. Haemolymph from infected snails reduced the...

journal_title：Neuroscience letters

authors： Hordijk PL,de Jong-Brink M,ter Maat A,Pieneman AW,Lodder JC,Kits KS

更新日期：1992-03-02 00:00:00

abstract：:beta-Amyloid protein immunoreactivity in neocortex and hippocampus of Alzheimer's disease and control brains has been measured using an automatic image analysis system. Successive fields from the pial surface to white matter in 4 neocortical sites, parahippocampal gyrus and along the pyramidal cell layer in the hippoc...

journal_title：Neuroscience letters

authors： Cairns NJ,Chadwick A,Luthert PJ,Lantos PL

更新日期：1991-08-05 00:00:00

abstract：:The neurotoxicant MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), administered to male or female mice, decreased striatal dopamine content and increased the levels of the astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP). The rise in GFAP was evident as early as two days following th...

journal_title：Neuroscience letters

authors： Reinhard JF Jr,Miller DB,O'Callaghan JP

更新日期：1988-12-19 00:00:00

abstract：:Dysbindin gene (DTNBP1) has been associated with schizophrenia, but literature findings are inconsistent, and further analyses are required. This study is aimed to investigate if a set of DTNBP1 variations might influence clinic psychotic phenotype or treatment response in a sample of 240 Korean schizophrenic in-patie...

journal_title：Neuroscience letters

authors： Pae CU,Drago A,Kim JJ,Patkar AA,Jun TY,Lee C,Mandelli L,De Ronchi D,Paik IH,Serretti A

更新日期：2008-08-01 00:00:00

abstract：:c-Fos is one of the transcription factors contributing to the regulation of the downstream gene expression. Administration of dopamine D1 receptor agonist or D2 receptor antagonist have been known to induce c-Fos expressions in striatal projection neurons. We examined the effects of unilateral ablation of the globus p...

journal_title：Neuroscience letters

authors： Miwa H,Fuwa T,Nishi K,Mizuno Y

更新日期：1998-01-16 00:00:00

abstract：:Quantitative neurophysiological studies have identified the presence of at least two spinal neuron populations (ABRUPT and SUSTAINED) which are excited by the noxious visceral stimulus colorectal distension (CRD). The present study examined the effects of acute colorectal inflammation on the activity of dorsal horn ne...

journal_title：Neuroscience letters

authors： Ness TJ,Gebhart GF

更新日期：2000-03-10 00:00:00

abstract：:Mesial temporal lobe epilepsy (MTLE) is a common type of intractable epilepsy characterized by astroglial gliosis. The S100B was viewed as an astrocyte marker and experimental studies indicated that S100B might be involved in the pathophysiology of temporal lobe epilepsy. In this study, we measured plasma S100B levels...

journal_title：Neuroscience letters

authors： Lu C,Li J,Sun W,Feng L,Li L,Liu A,Li J,Mao W,Wei H,Gao L,Zhang X,Huang Z,Meng X,Wang Y

更新日期：2010-10-29 00:00:00

abstract：:Propofol has been demonstrated as a drug of abuse in humans. Our previous study indicated that dexamethasone, a potent agonist of glucocorticoid receptor (GR), inhibited propofol-maintained rat self-administration behaviors by systematic injection. However, the direct effect of GR in the nucleus accumbens (NAc) on pro...

journal_title：Neuroscience letters

authors： Wu B,Lin W,Wang H,Abdullah T,Wang B,Su Y,Ge RS,Lian Q

更新日期：2018-01-01 00:00:00