Vascular endothelial growth factor expression under ischemic stress in human meningiomas.

Abstract:

:Vascular endothelial growth factor (VEGF) is an endothelial cell-specific antigen and angiogenic factor that plays a role in angiogenesis. We analyzed the expression of four VEGF mRNA isoforms in meningiomas. Among 35 meningiomas, 11 came from patients who underwent complete (n=4) or partial (n=7206=189 in all samples. However, the VEGF121 and 165 isoforms were significantly upregulated in samples from patients who underwent partial preoperative embolization. The diffusible VEGF121 isoform may be important for vascularity and edema formation in meningiomas.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Park K,Kim JH,Nam DH,Lee JI,Kim JS,Hong SC,Shin HJ,Eoh W,Park K

doi

10.1016/s0304-3940(00)00904-6

keywords:

subject

Has Abstract

pub_date

2000-03-31 00:00:00

pages

45-8

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(00)00904-6

journal_volume

283

pub_type

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