Short biotinylated oligonucleotides bind non-specifically to senile plaques of Alzheimer's disease.

abstract：:Central administration of colchicine causes accumulation of catecholamines in nerve cell bodies and enhances their visualisation in the rat brain by the formaldehyde-glutaraldehyde (FAGLU) histofluorescence method. The detection of catecholamine-containing nerve cells by the FAGLU method was considerably improved in r...

journal_title：Neuroscience letters

authors： Howe PR,Rogers PF,Blessing WW

更新日期：1984-12-21 00:00:00

abstract：:The terpene lactones of Ginkgo biloba extract, namely ginkgolides (A, B, and C) and bilobalide, possess antioxidant, anti-inflammatory, and neuroprotective effects. They are widely prescribed for the treatment of cerebral dysfunctions and neurological impairments. In addition, they demonstrate antagonistic action at t...

journal_title：Neuroscience letters

authors： Nishimon S,Yamaguchi M,Muraki H,Sakai N,Nishino S

更新日期：2020-03-23 00:00:00

abstract：OBJECTIVE:Numerous studies have reported P50 gating deficits in schizophrenia, though with mixed results. Moreover, few studies have explored the association between P50 gating deficits and psychopathology in Chinese patients with schizophrenia. In the present study, we investigated the P50 auditory sensory gating patt...

journal_title：Neuroscience letters

authors： Zhu XL,Tan SP,Wang ZR,Zhang JG,Li D,Fan FM,Zhao YL,Zou YZ,Tan YL,Yang F,Zhang XY

更新日期：2017-07-13 00:00:00

abstract：:Using frozen-thawed and extensively washed rat cortical membranes, the effects of 3-((+/-)2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) on [3H]N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine ([3H]TCP) binding stimulated by either 1 microM L-glutamate or 300 microM Mg2+ were examined. CPP much more potently inhibit...

journal_title：Neuroscience letters

authors： Hatta K,Yamamato T,Hori T,Okuwa M,Moroji T

更新日期：1991-04-01 00:00:00

abstract：:Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where they control stimulation-induced acetylcholi...

journal_title：Neuroscience letters

authors： Ambrosini A,de Noordhout AM,Alagona G,Dalpozzo F,Schoenen J

更新日期：1999-12-10 00:00:00

abstract：:Neuronal apoptosis sculpts the developing brain, and nearly all identified classes of neurons seem to be produced "in excess" during development. FoxO transcription factors regulate apoptosis in vitro in deprived of neurotrophins. It is unknown if FoxO3a is involved in the development of neurons. Here, we report a rol...

journal_title：Neuroscience letters

authors： Peng K,Li Y,Long L,Li D,Jia Q,Wang Y,Shen Q,Tang Y,Wen L,Kung HF,Peng Y

更新日期：2010-10-29 00:00:00

abstract：:In the present study, newborn male Wistar rats were injected, subcutaneously, five times, every other day, with monosodium glutamate (MSG, 4 g/kg bw) or saline (as control, C), during the neonatal period. MSG animals developed destruction of the arcuate nuclei (ARC) with absence of NPY-immunoreactive cell bodies, whic...

journal_title：Neuroscience letters

authors： de Andrade IS,Gonzalez JC,Hirata AE,Carneiro G,Amado D,Cavalheiro EA,Dolnikoff MS

更新日期：2006-05-01 00:00:00

abstract：:Most single fibers of the cochlear nerve (CN) in 22 cats exhibited effects of mechanical interaction in one cochlea between two sounds applied binaurally, similarly to results in two cats in which the contralateral CN was transected. In 11 of 189 fibers, the spontaneous and/or the sound-evoked activity was suppressed ...

journal_title：Neuroscience letters

authors： Murata K,Tanahashi T,Horikawa J,Funai H

更新日期：1980-07-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors which belong to the nuclear receptor family. We examined whether PPARalpha agonists and resveratrol, a polyphenol contained in grapes, protect the brain against ischemia. To investigate whether resveratrol activates PPARs, w...

journal_title：Neuroscience letters

authors： Inoue H,Jiang XF,Katayama T,Osada S,Umesono K,Namura S

更新日期：2003-12-11 00:00:00

abstract：:Contradictory results have been reported regarding the participation of bulbospinal inspiratory (BSI) neurons in vomiting contractions of the diaphragm in dogs and cats maintained at low and high end-tidal CO2 levels, respectively. To resolve this discrepancy, effects of CO2 levels on vomiting activities were observed...

journal_title：Neuroscience letters

authors： Koga T,Fukuda H

更新日期：1994-10-24 00:00:00

abstract：:The pharmacokinetics of 2-amino-7-phosphonoheptanoate (AP7) in rat plasma and appearance in cerebrospinal fluid (CSF) are reported. Using high-performance liquid chromatography (HPLC) with fluorescence detection, concentrations of AP7 can be detected as low as 1.0 microM. Peak CSF concentrations (12-15 microM) for bot...

journal_title：Neuroscience letters

authors： Compton RP,Hood WF,Monahan JB

更新日期：1988-02-03 00:00:00

abstract：:Compared to other M(1) muscarinic acetylcholine receptor (M(1) mAChR) agonists, xanomeline demonstrates both reversible and persistent modes of binding to the receptor. In our study, we investigated the long-term consequences of brief incubation of Chinese hamster ovary cells expressing M(1) mAChR (M(1)-CHO) with low ...

journal_title：Neuroscience letters

authors： De Lorme KC,Sikorski KL,Grant MK,El-Fakahany EE

更新日期：2006-12-13 00:00:00

abstract：:The gamma aminobutyric acid (GABA) system has been implicated in the susceptibility to develop alcohol dependence and in determining electroencephalogram (EEG) beta activity. The role of the GABA receptor alpha-2 gene (GABRA2) in human alcohol dependence was determined in a genetic and electrophysiological study. The ...

journal_title：Neuroscience letters

authors： Lydall GJ,Saini J,Ruparelia K,Montagnese S,McQuillin A,Guerrini I,Rao H,Reynolds G,Ball D,Smith I,Thomson AD,Morgan MY,Gurling HM

更新日期：2011-08-18 00:00:00

abstract：:An antiserum was raised against an amino acid sequence predicted from the DNA sequence of amyloid beta-protein precursor (ABPP), and it was then affinity-purified. This affinity-purified antibody (anti-GID) intensely stained neurons and dystrophic neurites in plaques of Alzheimer's disease (AD) patients, but marginall...

journal_title：Neuroscience letters

authors： Cole G,Masliah E,Huynh TV,DeTeresa R,Terry RD,Okuda C,Saitoh T

更新日期：1989-05-22 00:00:00

abstract：:The activities of monoamine oxidase (MAO)-A and -B in subcellular fractions of bovine retina were determined using serotonin and beta-phenylethylamine, respectively, as substrates. The subcellular fractions were a P1 fraction containing photoreceptor cell synaptosomes and a P2 fraction enriched with small synaptosomes...

journal_title：Neuroscience letters

authors： Sparks DL,Thomas TN,Buckholtz NS

更新日期：1981-01-20 00:00:00

abstract：:The present study examined effects of high altitude exposure, which leads to development of hypoxia, on epiplexus cells associated with the choroid plexus in adult rats. At 2-5 h following exposure, epiplexus cells expressing inducible nitric oxide synthase (iNOS) were commonly observed. Increased expression of comple...

journal_title：Neuroscience letters

authors： Wang D,Kaur C

更新日期：2000-05-19 00:00:00

abstract：:Whole-cell patch-clamp recordings (WCR) were made from sympathetic preganglionic neurons (SPN) in neonate rat spinal cord slices. SPN were identified histologically by filling them with the fluorescent dye Lucifer Yellow contained within the patch pipette solution. Current clamp recordings were obtained from SPN with ...

journal_title：Neuroscience letters

authors： Pickering AE,Spanswick D,Logan SD

更新日期：1991-09-16 00:00:00

abstract：:In vivo L-band electron spin resonance (ESR) system was used to measure the decay of nitroxide radicals in the living rat cerebrum containing a cortical area with an iron-induced epileptogenic region. Carbamoyl-PROXYL (3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolinyloxy) was injected intraperitoneally. The decay of nitrox...

journal_title：Neuroscience letters

authors： Komatsu M,Hiramatsu M,Yokoyama H,Willmore LJ

更新日期：1996-03-01 00:00:00

abstract：:People with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (Abeta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and Abeta1-40 and Abeta1-42 concentrations were found and nor were Abeta1-40 and Abeta1-42 levels...

journal_title：Neuroscience letters

authors： Jones EL,Hanney M,Francis PT,Ballard CG

更新日期：2009-02-20 00:00:00

abstract：:The effects of the group III mGluR agonist, L-2-amino-4-phosphonobutyrate (L-AP4), on depolarization-stimulated cGMP levels in adult rat cerebellar slices were determined. L-AP4 elicited a concentration-dependent, complete inhibition of cGMP formation stimulated by 4-aminopyridine (4-AP; 1 mM), yielding an IC50 value ...

journal_title：Neuroscience letters

authors： Cartmell J,Kemp JA,Mutel V

更新日期：1997-06-13 00:00:00

abstract：:Cerebral perfusion is important in older adults as it is linked to cognitive declines. Physical activity can improve blood flow in the body but little is known about the relationship between physical activity and cerebral perfusion in older adults. In particular, no study has investigated the relation between strength...

journal_title：Neuroscience letters

authors： Xu X,Jerskey BA,Cote DM,Walsh EG,Hassenstab JJ,Ladino ME,Clark US,Labbe DR,Gunstad JJ,Poppas A,Cohen RA,Hoge RD,Sweet LH

更新日期：2014-02-07 00:00:00

abstract：:The synucleins are a family of small proteins expressed in nervous tissue, which have been implicated in neurodegeneration. Using single strand conformation polymorphism analysis we screened for polymorphisms and mutations in the gene encoding human persyn, a recently discovered member of the synuclein family, in cont...

journal_title：Neuroscience letters

authors： Flowers JM,Leigh PN,Davies AM,Ninkina NN,Buchman VL,Vaughan J,Wood NW,Powell JF

更新日期：1999-10-15 00:00:00

abstract：:Research indicates that threat-induced changes in standing balance are associated with shifts in attention focus. This study investigated whether distracting attention modifies threat-induced changes in standing balance. Twenty-five healthy young adults stood without (No Threat) and with (Threat) the possibility of re...

journal_title：Neuroscience letters

authors： Johnson KJ,Watson AM,Tokuno CD,Carpenter MG,Adkin AL

更新日期：2020-01-18 00:00:00

abstract：:Since greater attention has been paid to the direct link of genetic variation to cognition and memory performance, apolipoprotein E (ApoE) and brain-derived neurotrophic factor (BDNF) have been the two most frequently studied genes. To investigate the effect of BDNF and ApoE polymorphisms on the cognitive profile of m...

journal_title：Neuroscience letters

authors： Nacmias B,Piccini C,Bagnoli S,Tedde A,Cellini E,Bracco L,Sorbi S

更新日期：2004-09-09 00:00:00

abstract：:In an attempt to understand the changes of circulating neuropeptide Y (NPY) during hypoxia, the plasma level of NPY was investigated by radioimmunoassay. Exposure of rats to hypobaric hypoxia at an altitude of 18,000 ft for 4 weeks causes an increase of pulmonary pressure and an elevation of plasma NPY-like immunoreac...

journal_title：Neuroscience letters

authors： Cheng JT,Chen CF,Shum AY,Wang JY,Chen HI

更新日期：1992-06-22 00:00:00

abstract：:A culture of peripheral nerve cells enriched in Schwann cells was obtained from sciatic nerve in normal and demyelinating trembler mutant. These cells incorporated and metabolized a non-physiological trans fatty acid (elaidic aid) as well as the physiological cis isomer (oleic acid). Both acids were incorporated simil...

journal_title：Neuroscience letters

authors： Bourre JM,Boutry JM,Masson M,Hauw JJ

更新日期：1982-05-28 00:00:00

abstract：:Post-mortem brain tissue from 15 patients dying with a diagnosis of senile dementia of Alzheimer type (SDAT) was compared with tissue obtained from 16 control patients at routine post-mortem. A significant fall in choline acetyltransferase (ChAT) activity was observed in the cortex, hippocampus and amygdala of the SDA...

journal_title：Neuroscience letters

authors： Rossor MN,Emson PC,Mountjoy CQ,Roth M,Iversen LL

更新日期：1980-12-01 00:00:00

abstract：:The effects of two Neuropeptide Y (NPY) analogs (Y1- and Y2-type) and vasoactive intestinal peptide (VIP) on both catecholamine (adrenaline and noradrenaline) release and aldosterone production by rat adrenal capsule/glomerular zone, have been investigated in vitro. The adrenal capsule/glomerular zones, collected from...

journal_title：Neuroscience letters

authors： Bernet F,Bernard J,Laborie C,Montel V,Maubert E,Dupouy JP

更新日期：1994-01-17 00:00:00

abstract：:A valinomycin-based membrane phase for microelectrodes with relatively low electrical membrane resistances is described. Microelectrodes with tip diameters of about 1 micron exhibit resistances of about 10(10) omega. Extremely high K+ selectivities are obtained, e.g. a rejection of Na+ by a factor of 5000 and of acety...

journal_title：Neuroscience letters

authors： Ammann D,Chao PS,Simon W

更新日期：1987-02-24 00:00:00

abstract：:In the present study, the effects of fluvoxamine on the inhibition of gastrointestinal transit, antinociception and hyperlocomotion induced by morphine were investigated in mice. Treatment with morphine (10 mg/kg, subcutaneously (s.c.)) inhibited gastrointestinal transit and hyperlocomotion. These effects were attenua...

journal_title：Neuroscience letters

authors： Ise Y,Katayama S,Hirano M,Aoki T,Narita M,Suzuki T

更新日期：2001-02-16 00:00:00