Mutations in the gene encoding human persyn are not associated with amyotrophic lateral sclerosis or familial Parkinson's disease.

abstract：:We have studied the electrophysiological properties of hippocampal neurons grown on surfaces of organic thin films formed on glass or silicon substrates and on microelectronic device surfaces in culture. Hippocampal neurons were dissociated from embryonic rats and plated on substrates chemically modified with laminin ...

journal_title：Neuroscience letters

authors： Offenhäusser A,Sprössler C,Matsuzawa M,Knoll W

更新日期：1997-02-14 00:00:00

abstract：:Previously, trophic effects of extracts from whole chick embryos and from innervated muscles on cultured muscle cells were described. The present study demonstrated similar effects of extracts from 10-days denervated chick muscles. Extracts from innervated as well as from denervated muscles exsanguinated in vivo with ...

journal_title：Neuroscience letters

authors： Hooisma J,De Krijger J,De Groot DM,Magchielse T,Muijser H

更新日期：1981-02-23 00:00:00

abstract：:The effects of acute treatment with 1,2,3,4-tetrahydro-9-aminoacridine (THA), a 4-aminopyridine derivative clinically effective in Alzheimer's disease, on beta-adrenoceptor-linked cyclic AMP accumulation have been investigated in cortical and hippocampal structures of young and middle-aged rats. In a first series of e...

journal_title：Neuroscience letters

authors： Dierssen M,Màrmol F,Vivas NM,Clos MV,Gascón S,Badia A

更新日期：1991-10-28 00:00:00

abstract：:AMPA receptor (AMPAR) trafficking has emerged as a fundamental concept for understanding mechanisms of learning and memory as well as many neurological disorders. Classical conditioning is a simple and highly conserved form of associative learning. Our studies use an ex vivo brainstem preparation in which to study cel...

journal_title：Neuroscience letters

authors： Keifer J,Tiwari NK,Buse L,Zheng Z

更新日期：2017-04-03 00:00:00

abstract：:The injection of oxytocin into the third ventricle during suckling in lactating rats not only enhances neurosecretory bursts but also the background activity of oxytocin cells. However, removing the young rats 10 min after the oxytocin injection is immediately followed by a decrease in background activity, while injec...

journal_title：Neuroscience letters

authors： Meyer C,Freund-Mercier MJ,Richard P

更新日期：1987-03-20 00:00:00

abstract：:In vivo formation of 1-methyl-4-phenylpyridinium ion (MPP(+)) in the striatum, and dopaminergic neurotoxicity following systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the presence and absence of calcium channel agonist (+/-)-Bay K8644 were analyzed in Balb/c mice. We used HPLC-photod...

journal_title：Neuroscience letters

authors： Samantaray S,Mohanakumar KP

更新日期：2003-07-31 00:00:00

abstract：:Visceral nociceptive information is transmitted in two different areas of the spinal cord gray matter, the dorsal horn and the area near the central canal. The present study was designed to examine whether visceral nociceptive transmission in the two different areas is under the control of the centrifugal pathways fro...

journal_title：Neuroscience letters

authors： Liu L,Tsuruoka M,Maeda M,Hayashi B,Inoue T

更新日期：2007-10-22 00:00:00

abstract：:The somatosensory homunculus has been identified during stimulation of median (at wrist and elbow), femoral, tibial and pudendal nerves of the left hemibody via the neuromagnetic imaging technique. The somatic representations of different body districts have been localized in the somatosensory cortex, by means of an e...

journal_title：Neuroscience letters

authors： Narici L,Modena I,Opsomer RJ,Pizzella V,Romani GL,Torrioli G,Traversa R,Rossini PM

更新日期：1991-01-02 00:00:00

abstract：:The roles played by glycine- and glutamate-mediated synaptic transmission in the generation of 5-hydroxytryptamine (5-HT)-induced rhythmic activity were examined in isolated spinal cord preparations from fetal rats. Bath application of 5-HT (0.1-30 microM) evoked rhythmic activity in lumbar ventral roots at and after ...

journal_title：Neuroscience letters

authors： Nakayama K,Nishimaru H,Kudo N

更新日期：2001-07-06 00:00:00

abstract：:By recording the locomotor activity rhythm of hagfish, Eptatretus burgeri, in which surgical lesions of the preoptic nucleus (PON) were made, we searched for the location of the circadian pacemaker in the hypothalamus. The characteristic rhythms were lost in animals lacking the anterior part of the hypothalamus, which...

journal_title：Neuroscience letters

authors： Ooka-Souda S,Kadota T,Kabasawa H

更新日期：1993-12-24 00:00:00

abstract：:Many gene expression studies have examined postmortem brain tissues of patients with schizophrenia. However, only a few expression studies of the genes identified in genome-wide association study (GWAS) have been published to date. We measured the expression levels of the genes identified in GWAS (ZNF804A, OPCML, RPGR...

journal_title：Neuroscience letters

authors： Umeda-Yano S,Hashimoto R,Yamamori H,Weickert CS,Yasuda Y,Ohi K,Fujimoto M,Ito A,Takeda M

更新日期：2014-05-07 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) is enriched in the central nervous system, including the dopamine responsive regions such as the striatum and medial prefrontal cortex (mPFC). The kinase is sensitive to changing cellular and synaptic input and is implicated in the regulation of synaptic transmission and...

journal_title：Neuroscience letters

authors： Mao LM,Wang JQ

更新日期：2019-04-23 00:00:00

abstract：:Plasminogen belongs to the plasminogen activator system of cell signaling proteins and has recently been identified to bind to pathological prion protein PrPSC, but not to its normal conformer, PrPC. Plasminogen binds specifically to the urokinase-type plasminogen activator receptor (uPAR) to promote pericellular prot...

journal_title：Neuroscience letters

authors： Deininger MH,Trautmann K,Magdolen V,Luther T,Schluesener HJ,Meyermann R

更新日期：2002-05-10 00:00:00

abstract：:Abnormalities of cortical representational maps and their plasticity have been described in dystonia. A common polymorphism for BDNF has been associated with abnormal cortical plasticity, and thus might contribute to pathogenesis of dystonia in some subjects. As a first step towards this suggestion, the current study ...

journal_title：Neuroscience letters

authors： Cramer SC,Sampat A,Haske-Palomino M,Nguyen S,Procaccio V,Hermanowicz N

更新日期：2010-01-01 00:00:00

abstract：:We measured levels of basal and norepinephrine (NE) -induced melatonin release in cultured pineal bodies of rats just after and 2 days after irradiation (20 or 200 Gy) or sham-irradiation. On the day of irradiation, basal and NE-induced melatonin release were not affected by irradiation. Two days after irradiation, ba...

journal_title：Neuroscience letters

authors： Saito K,Shinohara K,Morofushi M,Funabashi T,Mitsushima D,Hata M,Matsubara S,Kimura F

更新日期：2000-04-21 00:00:00

abstract：:Membrane currents of cultured human monocytes and rat microglia were recorded with the whole-cell patch clamp technique. Freshly isolated monocytes or resting (proliferating) microglia express only inwardly rectifying K+ channels. However, incubation in teflon bags leads to the expression of additional, outwardly rect...

journal_title：Neuroscience letters

authors： Nörenberg W,Appel K,Bauer J,Gebicke-Haerter PJ,Illes P

更新日期：1993-09-17 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease and its prevalence increases with age. The microtubule-associated protein tau (MAPT) is thought to be implicated in the pathogenesis of PD. Association of the MAPT H1 haplotype with PD in Caucasians has been extensively studied, however, the results were inconsis...

journal_title：Neuroscience letters

authors： Kobayashi H,Ujike H,Hasegawa J,Yamamoto M,Kanzaki A,Sora I

更新日期：2006-09-25 00:00:00

abstract：:The effects of gender and gonadal hormones on nociceptive responses to intraplantar carrageenan in the rat were investigated. A plantar analgesic meter was used to measure carrageenan-induced changes in paw withdrawal latency (PWL) values, and von Frey monofilaments were used to assess changes in paw withdrawal thresh...

journal_title：Neuroscience letters

authors： Tall JM,Crisp T

更新日期：2004-01-16 00:00:00

abstract：:The Flinders Sensitive Line rats showed an increased immobility response by 104% (P<0.01) in the forced swim test with respect to the Flinders Resistant Line rats (control). The Flinders Sensitive Line rats also had an increase of [(125)I]galanin (porcine) binding in the dorsal raphe (55+/-3.3 fmol/mg protein) with re...

journal_title：Neuroscience letters

authors： Bellido I,Díaz-Cabiale Z,Jiménez-Vasquez PA,Andbjer B,Mathé AA,Fuxe K

更新日期：2002-01-11 00:00:00

abstract：:The pharmacokinetics of 2-amino-7-phosphonoheptanoate (AP7) in rat plasma and appearance in cerebrospinal fluid (CSF) are reported. Using high-performance liquid chromatography (HPLC) with fluorescence detection, concentrations of AP7 can be detected as low as 1.0 microM. Peak CSF concentrations (12-15 microM) for bot...

journal_title：Neuroscience letters

authors： Compton RP,Hood WF,Monahan JB

更新日期：1988-02-03 00:00:00

abstract：:Survivors of bacterial meningitis frequently suffer from long-term sequelae, particularly from learning and memory deficits. For this reason, spatial memory and learning was studied in a mouse model of ceftriaxone-treated Streptococcus pneumoniae meningitis. Persistent deficits of spatial learning despite normal motor...

journal_title：Neuroscience letters

authors： Wellmer A,Noeske C,Gerber J,Munzel U,Nau R

更新日期：2000-12-22 00:00:00

abstract：:Tyrosine hydroxylase-like immunoreactive (TH-IR) neurons with morphological features of interneurons were found throughout the human cerebral cortex. Quantitative estimates in 14 different cytoarchitectonic areas revealed a specific regional distribution pattern, neurons being less dense in primary cortical areas and ...

journal_title：Neuroscience letters

authors： Gaspar P,Berger B,Febvret A,Vigny A,Krieger-Poulet M,Borri-Voltattorni C

更新日期：1987-10-05 00:00:00

abstract：:We used an intracellular microelectrode technique to study the mechanisms of action of two isoforms (human and rat) of calcitonin gene-related peptide (CGRP) on the evoked and spontaneous quantal secretion of acetylcholine (ACh) in mouse diaphragm motor synapses. Recordings of miniature endplate potentials (MEPPs) and...

journal_title：Neuroscience letters

authors： Gaydukov AE,Bogacheva PO,Balezina OP

更新日期：2016-08-15 00:00:00

abstract：:We report a sporadic case of tauopathy with unusual clinical and neuropathological features. The patient presented with progressive symmetric rigid-akinetic parkinsonism and dementia of the subcortical type. Magnetic resonance imaging of the brain revealed atrophy resembling multiple system atrophy. The level of cereb...

journal_title：Neuroscience letters

authors： Ohara S,Tsuyuzaki J,Oide T,Arai H,Higuchi S,Hasegawa M,Iwatsubo T

更新日期：2002-09-13 00:00:00

abstract：:Interleukin-1 beta (IL-1 beta), interleukin-2 (IL-2), and interleukin-6 (IL-6) were measured in the cerebrospinal fluid (CSF) and plasma of 12 control subjects, 11 sporadic Alzheimer's disease (AD) and 22 de novo Parkinson's disease (PD) patients using high sensitivity enzyme-linked immunosorbent assays (ELISA). IL-1 ...

journal_title：Neuroscience letters

authors： Blum-Degen D,Müller T,Kuhn W,Gerlach M,Przuntek H,Riederer P

更新日期：1995-12-29 00:00:00

abstract：:The serotonergic dorsal raphé nucleus (DRN) expresses glucocorticoid receptors (GR), and systemic glucocorticoids have been shown to regulate expression and activity of tryptophan hydroxylase isoform 2, the rate-limiting enzyme for serotonin synthesis in brain. We have used intra-DRN injection of pseudotyped adeno-ass...

journal_title：Neuroscience letters

authors： Vincent MY,Donner NC,Smith DG,Lowry CA,Jacobson L

更新日期：2018-02-05 00:00:00

abstract：:Although corticotropin-releasing factor (CRF) is thought to act as a neurotransmitter to activate the locus coeruleus (LC) during hypotensive stress, the consequences of LC activation by CRF are unknown. In the present study a hypotensive challenge that activated rat LC neurons also produced cortical electroencephalog...

journal_title：Neuroscience letters

authors： Page ME,Berridge CW,Foote SL,Valentino RJ

更新日期：1993-12-24 00:00:00

abstract：:Stress is a major risk factor in drug addiction development and relapse. Virtually all drugs of abuse act by increasing extracellular dopamine levels in the striatum. To gain an understanding of the interaction between stress and drug exposure, we studied the effects of concomitant chronic nicotine and chronic stress ...

journal_title：Neuroscience letters

authors： Salas R,De Biasi M

更新日期：2008-07-25 00:00:00

abstract：:Neuropeptides, synthesized in dorsal root ganglia (DRG), are implicated in nociception and neurogenic inflammation. Alterations in DRG neuropeptide levels have been described in polyarthritic rats, but these models are associated with widespread systemic disease. Using mild adjuvant-mediated monoarthritis of the left ...

journal_title：Neuroscience letters

authors： Smith GD,Harmar AJ,McQueen DS,Seckl JR

更新日期：1992-03-30 00:00:00

abstract：:It has been demonstrated that immunization of transgenic mouse models of Alzheimer's disease (AD) with amyloid-beta1-42 peptide (Abeta1-42) results in amelioration of AD-like pathology, including reduced soluble and deposited beta-amyloid and decreased cognitive impairment. Based on the proposed importance of immunogl...

journal_title：Neuroscience letters

authors： Town T,Tan J,Sansone N,Obregon D,Klein T,Mullan M

更新日期：2001-07-13 00:00:00