Corticotropin-releasing factor in the locus coeruleus mediates EEG activation associated with hypotensive stress.

Abstract:

:Although corticotropin-releasing factor (CRF) is thought to act as a neurotransmitter to activate the locus coeruleus (LC) during hypotensive stress, the consequences of LC activation by CRF are unknown. In the present study a hypotensive challenge that activated rat LC neurons also produced cortical electroencephalographic (EEG) correlates of arousal. Selective, bilateral LC inactivation by local clonidine infusion prevented EEG activation associated with hypotension. Additionally, bilateral LC infusion of CRF antagonists prevented both LC and EEG activation by this challenge. These results indicate that CRF, acting as a neurotransmitter to activate LC during stress, has a powerful of modulatory influence over global forebrain electrophysiological activity.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Page ME,Berridge CW,Foote SL,Valentino RJ

doi

10.1016/0304-3940(93)90862-f

subject

Has Abstract

pub_date

1993-12-24 00:00:00

pages

81-4

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(93)90862-F

journal_volume

164

pub_type

杂志文章
  • Two types of calcium channels regulating activation of proline-rich tyrosine kinase 2 induced by transient brain ischemia in rat hippocampus.

    abstract::Tyrosine phosphorylation is an important means for regulating post-ischemic signal transduction. In this article, brain ischemia was induced by four-vessel occlusion, and the effect of ischemia/reperfusion on proline-rich tyrosine kinase 2 (Pyk2) was studied. Tyrosine phosphorylation of Pyk2 in Sprague-Dawley rat hipp...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(03)00618-9

    authors: Liu Y,Zhang GY,Hou XY,Xu TL

    更新日期:2003-09-18 00:00:00

  • Pattern of time-dependent reduction of histologically determined infarct volume after focal ischaemia in mice.

    abstract::The mouse model of transcranial permanent occlusion of the middle cerebral artery (tpMCAO) is widely used in stroke research. Here we quantified infarct size using a conventional histological method at several post-ischaemic times, going beyond the commonly analysed period of up to 2 days, following artery occlusion. ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.12.029

    authors: Henrich-Noack P,Baldauf K,Reiser G,Reymann KG

    更新日期:2008-02-20 00:00:00

  • Kainic acid binding in human caudate nucleus: effect of Huntington's disease.

    abstract::Kainic acid binding was measured in crude membrane fractions prepared from postmortem human caudate tissue of control persons and patients afflicted with Huntington's disease. A significant reduction in binding sites with no change in affinity was found in the Huntington's tissue, the apparent dissociation constants (...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(79)96156-1

    authors: Henke H

    更新日期:1979-10-01 00:00:00

  • Alteration of myo-inositol monophosphatase in Alzheimer's disease brains.

    abstract::myo-Inositol monophosphatase (E.C.3.1.3.25) catalyzes the hydrolysis of myo-inositol 1-phosphate in the presence of Mg2+ at a physiologic pH to form free myo-inositol, maintaining a supply that represents the precursor for inositol phospholipid second messenger signaling systems. In the present study the activity and ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(98)00209-2

    authors: Shimohama S,Tanino H,Sumida Y,Tsuda J,Fujimoto S

    更新日期:1998-04-10 00:00:00

  • Expression and anatomical distribution of TrkB in the encephalon of the adult zebrafish (Danio rerio).

    abstract::Neurotrophins are a family of growth factor primarily acting in the nervous system, throughout two categories of membrane receptors on the basis of their high (Trk receptors) or low (p75NTR) affinity. Both neurotrophins and Trk receptors are phylogenetically conserved and are expressed not only in the central and peri...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.01.031

    authors: Abbate F,Guerrera MC,Montalbano G,Levanti MB,Germanà GP,Navarra M,Laurà R,Vega JA,Ciriaco E,Germanà A

    更新日期:2014-03-20 00:00:00

  • Detection of 5-HT3R-A, a 5-HT3 receptor subunit, in submucosal and myenteric ganglia of rat small intestine using in situ hybridization.

    abstract::Physiological and radioligand binding studies have demonstrated the existence of 5-HT3 receptors in the enteric nervous system. In order to determine if the cloned 5-HT3 receptor subunit, 5-HT3R-A, was expressed in the enteric nervous system of rats, we have performed in situ hybridization with 33P-labeled cRNA antise...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)11170-n

    authors: Johnson DS,Heinemann SF

    更新日期:1995-01-16 00:00:00

  • Plasma gelsolin and matrix metalloproteinase 3 as potential biomarkers for Alzheimer disease.

    abstract::Gelsolin (GSN) levels and matrix metalloproteinase 3 (MMP3) activity have been found to be altered in the plasma in patients with Alzheimer disease (AD). The aim of this study was to determine whether a combination of these proteins with clinical data is specific and sensitive enough for AD diagnosis. In 113 non-demen...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2015.04.014

    authors: Peng M,Jia J,Qin W

    更新日期:2015-05-19 00:00:00

  • Possible involvement of the facial nucleus in regulation of respiration in rats.

    abstract::The facial nucleus (FN) has been known as a motor nucleus to control the activity of the facial skeletal muscles by its efferent somatic motoneurons. Much less, however, is known about the non-motor control functions of its interneurons. The present study was designed to investigate if the interneurons of the FN parti...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.06.047

    authors: Zhang C,Yan H,Li C,Zheng Y

    更新日期:2004-09-09 00:00:00

  • Neurotrophic factors increase tumor necrosis factor-alpha-induced nuclear translocation of NF-kappaB in rat PC12 cells.

    abstract::Neurotrophic factors regulate neuronal survival and differentiation and control neurite outgrowth by binding to tyrosine kinase receptors, the Trks, and a tumor necrosis factor (TNF) receptor-like molecule, p75 neurotrophin receptor. A proinflammatory cytokine, TNF, also affects survival and apoptotic death in neurona...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.09.031

    authors: Furuno T,Nakanishi M

    更新日期:2006-01-16 00:00:00

  • Functional expression and adaptive regulation of Na+ -dependent neutral amino acid transporter SNAT2/ATA2 in normal human astrocytes under amino acid starved condition.

    abstract::We reported here the functional characteristics of Na+ -dependent neutral amino acid transport system A in normal human astrocytes and its adaptive regulation, a process in which amino acid starvation induces the transport activity. Reverse transcription-PCR revealed that the system A transporter subtype, SNAT2/ATA2, ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.12.030

    authors: Tanaka K,Yamamoto A,Fujita T

    更新日期:2005-04-18 00:00:00

  • Antinociceptive effects of a pulsed magnetic field in the land snail, Cepaea nemoralis.

    abstract::Pulsed magnetic fields (patent pending) consisting of approximately 100 microT (peak), frequency modulated, extremely low frequency magnetic fields (ELFMF) were shown to induce a significant degree of antinociception ('analgesia') in the land snail Cepaea nemoralis. Fifteen minute exposures to a specific magnetic fiel...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)13359-6

    authors: Thomas AW,Kavaliers M,Prato FS,Ossenkopp KP

    更新日期:1997-01-31 00:00:00

  • Action of thymol on spontaneous excitatory transmission in adult rat spinal substantia gelatinosa neurons.

    abstract::Thymol, which is contained in thyme essential oil, has various actions including antinociception and nerve conduction inhibition. Although thymol activates transient receptor potential (TRP) channels expressed in heterologous cells, it remains to be examined whether this is so in native neurons. It has not yet been ex...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2015.08.042

    authors: Xu ZH,Wang C,Fujita T,Jiang CY,Kumamoto E

    更新日期:2015-10-08 00:00:00

  • Glucagon-induced somatostatin release from perifused rat hypothalamus: calcium dependency and effect of cysteamine treatment.

    abstract::Somatostatin (SRIF) release from rat hypothalamus was investigated in vitro with a perifusion system. Glucagon (1 microM) and high potassium concentrations (56 mM) stimulated SRIF release in a calcium-dependent manner. Pretreatment of the rat with cysteamine (30 mg/100 g body weight, 7 h earlier) significantly reduced...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(83)90445-7

    authors: Shimatsu A,Kato Y,Matsushita N,Ohta H,Kabayama Y,Imura H

    更新日期:1983-06-30 00:00:00

  • Neurite outgrowth is enhanced by conditioning factor(s) released from central ganglia of Aplysia californica.

    abstract::Single neurons of Aplysia californica were cultured on control and conditioned medium-treated cover slips (CM, derived from central ganglia of Aplysia) and fed with L-15 medium plus 20% hemolymph. After 5 h 36.9 +/- 3.3% of all neurons plated on CM-treated cover slips sprouted, whereas only 22.9 +/- 2.7% sprouted in t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)12004-n

    authors: Fejtl M,Carpenter DO

    更新日期:1995-10-13 00:00:00

  • Decreases in tissue levels of ubiquinol-9 and -10, ascorbate and alpha-tocopherol following spinal cord impact trauma in rats.

    abstract::Generation of free radicals and subsequent lipid peroxidation have been proposed to contribute to delayed tissue damage following traumatic spinal cord injury (SCI). Ubiquinols (reduced coenzyme Q), ascorbate (vitamin C), and alpha-tocopherol (vitamin E) are endogenous antioxidants; decreases in tissue levels of these...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90731-n

    authors: Lemke M,Frei B,Ames BN,Faden AI

    更新日期:1990-01-01 00:00:00

  • Transient activation of protein phosphatase 2A induced by electroconvulsive shock in the rat frontal cortex.

    abstract::We have attempted to determine the effects of electroconvulsive shock (ECS) on protein phosphatase 2A (PP2A) in the frontal cortices of rats. PP2A exhibited a 30% increase in activity immediately after ECS treatment. Immunoblot analysis revealed that phosphorylation signals, including protein kinase B (Akt/PKB), glyco...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.08.020

    authors: Kang UG,Jeon WJ,Kim Y,Chung CK,Park JB,Juhnn YS,Kim YS

    更新日期:2005-12-30 00:00:00

  • Differential engagement of anterior cingulate and adjacent medial frontal cortex in adept meditators and non-meditators.

    abstract::This study investigated differences in brain activation during meditation between meditators and non-meditators. Fifteen Vipassana meditators (mean practice: 7.9 years, 2h daily) and fifteen non-meditators, matched for sex, age, education, and handedness, participated in a block-design fMRI study that included mindful...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.04.074

    authors: Hölzel BK,Ott U,Hempel H,Hackl A,Wolf K,Stark R,Vaitl D

    更新日期:2007-06-21 00:00:00

  • Inhibition of vitamin B12 metabolism by OH-cobalamin c-lactam in rat oligodendrocytes in culture: a model for studying neuropathy due to vitamin B12 deficiency.

    abstract::Vitamin B12 is implicated in methylation processes. Myelin basic protein is methylated on one arginine group. A defect in methylation could produce an unstable protein, leading to neurological disorders. In order to study myelin basic protein, we have developed the cultures of newborn rat oligodendrocytes in vitamin B...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01243-x

    authors: Sponne IE,Gaire D,Stabler SP,Droesch S,Barbé FM,Allen RH,Lambert DA,Nicolas JP

    更新日期:2000-07-21 00:00:00

  • Absence of SHATI/Nat8l reduces social interaction in mice.

    abstract::We previously identified a novel molecule "Shati/Nat8l" from the nucleus accumbens of mice. However, the physiological roles of the SHATI protein are not clear. To investigate the effect of SHATI on the central nervous system and behavior, we studied knockout mice of this protein. We carried out various behavior tests...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.08.028

    authors: Furukawa-Hibi Y,Nitta A,Fukumitsu H,Somiya H,Toriumi K,Furukawa S,Nabeshima T,Yamada K

    更新日期:2012-09-27 00:00:00

  • Spirulina maxima extract prevents cell death through BDNF activation against amyloid beta 1-42 (Aβ1-42) induced neurotoxicity in PC12 cells.

    abstract::Spirulina maxima is a blue-green micro alga that contains abundant amounts of proteins (60-70%), vitamins, chlorophyll a, and C-phycocyanin (C-PC). It has been shown to reduce oxidative stress, and prevent diabetes and non-alcoholic fatty liver disease. However, it is unclear whether Spirulina maxima 70% ethanol extra...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2018.02.057

    authors: Koh EJ,Kim KJ,Choi J,Kang DH,Lee BY

    更新日期:2018-04-23 00:00:00

  • Coeruleospinal inhibition of visceral nociceptive processing in the rat spinal cord.

    abstract::Visceral nociceptive information is transmitted in two different areas of the spinal cord gray matter, the dorsal horn and the area near the central canal. The present study was designed to examine whether visceral nociceptive transmission in the two different areas is under the control of the centrifugal pathways fro...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.06.030

    authors: Liu L,Tsuruoka M,Maeda M,Hayashi B,Inoue T

    更新日期:2007-10-22 00:00:00

  • Glutathione redox status in mitochondria and cytoplasm differentially and sequentially activates apoptosis cascade in dopamine-melanin-treated SH-SY5Y cells.

    abstract::Neuromelanin (NM)-containing dopaminergic neurons in the substantia nigra are selectively vulnerable in Parkinson's disease (PD), suggesting the involvement of NM in the pathogenesis. NM is composed of protein, lipid, trace metals and melanin component, a mixture of eumelanin produced from dopamine (DA)-quinone and ph...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.08.082

    authors: Naoi M,Yi H,Maruyama W,Inaba K,Shamoto-Nagai M,Akao Y,Gerlach M,Riederer P

    更新日期:2009-11-13 00:00:00

  • Ultrastructural demonstration of serotonin-immunoreactivity in the nervous system of an insect (Calliphora erythrocephala).

    abstract::Serotonin (5-HT) immunocytochemistry, was performed on the whole dissected nervous system of the blowfly. Employing the peroxidase-antiperoxidase technique and osmium postfixation, it was possible to examine 5-HT-immunoreactive neuronal elements first light microscopically in 25 microns sections, and, after re-embeddi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90020-x

    authors: Nässel DR,Elekes K

    更新日期:1984-07-27 00:00:00

  • The effect of imperceptible Gaussian tendon vibration on the Hoffmann reflex.

    abstract::Imperceptible vibratory Gaussian noise stimulation to the periphery is frequently being applied to humans to enhance motor performance. It is commonly theorized that this stimulation creates a Stochastic Resonance-like effect across both sensory and motor systems, but this idea has no empirical support. In contrast, t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2019.05.018

    authors: Tenan MS,Tweedell AJ,Haynes CA,Passaro AD

    更新日期:2019-07-27 00:00:00

  • Spinal opioid receptors and inhibition of urinary bladder motility in vivo.

    abstract::The effects of intrathecal injections of morphine and other opioid receptor selective drugs were tested on urinary bladder contractions in the anesthetized rat. Morphine produced dose-related inhibition of bladder motility which was abolished by naloxone. This action was also observed with mu- and delta-opioid recepto...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90390-2

    authors: Dray A,Metsch R

    更新日期:1984-06-01 00:00:00

  • Histaminergic effects on the frequency of repetitive spike firing in rat insular cortex.

    abstract::The insular cortex (IC) processes multimodal sensory information including gustatory, visceral, nociceptive, and thermal sensation, and is considered to play a role in the regulation of homeostasis. The IC receives dense histaminergic projection from the tuberomamillary nucleus in the hypothalamus, and recent studies ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.04.056

    authors: Takei H,Song L,Ebihara K,Shirakawa T,Koshikawa N,Kobayashi M

    更新日期:2012-06-14 00:00:00

  • Regulation of MHC molecules on MBP positive oligodendrocytes in mice by IFN-gamma and TNF-alpha.

    abstract::The expression of class I and class II histocompatibility antigens by myelin basic protein (MBP)-positive oligodendrocytes, in response to exogenous cytokines, has been investigated in vitro. It has been found that interferon-gamma (IFN-gamma), although capable of class I induction, does not induce class II on oligode...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90154-l

    authors: Turnley AM,Miller JF,Bartlett PF

    更新日期:1991-02-11 00:00:00

  • Characterization of neuronal responses in the zona incerta of the subthalamic region of the sheep during ingestion of food and liquid.

    abstract::Single-unit recordings were made from the zona incerta of the subthalamic region of conscious sheep during ingestion. Some cells responded to ingestion and not to associated chewing, arousal or odour stimuli. Most cells changed their activity shortly after food entered the mouth and throughout ingestion, but a few res...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90362-9

    authors: Kendrick KM,Baldwin BA

    更新日期:1986-01-30 00:00:00

  • High and low nightly running behavior associates with nucleus accumbens N-Methyl-d-aspartate receptor (NMDAR) NR1 subunit expression and NMDAR functional differences.

    abstract::The extent to which N-Methyl-d-aspartate (NMDA) receptors facilitate the motivation to voluntarily wheel-run in rodents has yet to be determined. In so, we utilized female Wistar rats selectively bred to voluntarily run high (HVR) and low (LVR) nightly distances in order to examine if endogenous differences in nucleus...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2018.02.011

    authors: Grigsby KB,Kovarik CM,Rottinghaus GE,Booth FW

    更新日期:2018-04-03 00:00:00

  • Brain but not retinal glial cells have carbonic anhydrase activity in the honeybee drone.

    abstract::Carbonic anhydrase (CA) activity was localized histochemically in the retina and brain of the honeybee drone. A positive reaction that could be inhibited with 10(-5) M acetazolamide was found only in brain glial cells such as those in the lamina and medulla of the optic lobes. In the retina, neither the photoreceptors...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90426-0

    authors: Walz B

    更新日期:1988-02-15 00:00:00