Detection of 5-HT3R-A, a 5-HT3 receptor subunit, in submucosal and myenteric ganglia of rat small intestine using in situ hybridization.

abstract：:The synapsin III gene, SYN3, which belongs to the family of synaptic vesicle-associated proteins, has been implicated in the modulation of neurotransmitter release and in synaptogenesis, suggesting a potential role in several neuropsychiatric diseases. The human SYN3 gene is located on chromosome 22q12-13, a candidate...

journal_title：Neuroscience letters

authors： Chen Q,Che R,Wang X,O'Neill FA,Walsh D,Tang W,Shi Y,He L,Kendler KS,Chen X

更新日期：2009-11-20 00:00:00

abstract：:The most current human-based studies in which brain-derived neurotrophic factor (BDNF) levels in the peripheral blood system are analyzed use it as an indicator that represents BDNF levels in the CNS. However, whether circulating BDNF (serum and plasma) is positively or inversely associated with cardiorespiratory fitn...

journal_title：Neuroscience letters

authors： Cho HC,Kim J,Kim S,Son YH,Lee N,Jung SH

更新日期：2012-06-21 00:00:00

abstract：:Recent studies suggest that mild hypothermia significantly alleviate damage following cerebral ischemia though the precise mechanism is poorly defined. In the present study, middle cerebral artery occlusion (MCAo) was induced in Sprague-Dawley (SD) rats for 1 h followed by varying periods of reperfusion. Cerebral infa...

journal_title：Neuroscience letters

authors： Prakasa Babu P,Yoshida Y,Su M,Segura M,Kawamura S,Yasui N

更新日期：2000-09-22 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) plays an important role in the regulation of energy balance. While the regulation of TRH in the paraventricular nucleus (PVN) in response to changes of energy balance has been well studied, how TRH is regulated in the dorsomedial hypothalamus (DMH) in maintaining energy homeostasis ...

journal_title：Neuroscience letters

authors： Zhang N,Zhang HY,Bi SA,Moran TH,Bi S

更新日期：2019-06-11 00:00:00

abstract：:Galantamine, which is currently used in the treatment of patients with Alzheimer's disease (AD), has been shown to have a neuroprotective effect against beta-amyloid (Abeta) peptide-induced toxicity, which is involved in the pathogenesis of AD. In this study, we investigated the mechanism underlying the protective eff...

journal_title：Neuroscience letters

authors： Li Q,Fang J,Yang M,Wu D,Zhang L,Zhang Y

更新日期：2010-08-23 00:00:00

abstract：:UBB+1 protein is an aberrant ubiquitin associated with progressive supranuclear palsy (PSP). It leads to proteasome inhibition, heat-shock protein (HSP) expression and apoptosis in cell cultures. Despite UBB+1 polyubiquitination (an indication of proteasome inhibition), we demonstrate that UBB+1 and HSP40/HSP70 immuno...

journal_title：Neuroscience letters

authors： Hope AD,Lashley T,Lees AJ,de Silva R

更新日期：2004-04-08 00:00:00

abstract：:Recently, we reported that a centrally acting non-narcotic antitussive (cough suppressant drug), tipepidine produces an antidepressant-like effect in the forced swimming test in rats. Because pharmacological properties of tipepidine apparently differ from those of typical antidepressants developed to date, we speculat...

journal_title：Neuroscience letters

authors： Kawaura K,Miki R,Shima E,Honda S,Soeda F,Shirasaki T,Takahama K

更新日期：2010-09-13 00:00:00

abstract：:To search for brain molecules that share epitopes with HIV (human immunodeficiency virus) proteins, we investigated non-AIDS human brains by immunohistochemical and Western blotting methods, and detected a 23 kDa protein which was immunoreactive with antibodies against HIVp17, a core protein of HIV with a molecular we...

journal_title：Neuroscience letters

authors： Kato T,Kurita K,Kawanami T,Sasaki H

更新日期：1994-11-07 00:00:00

abstract：:The axonal efferents of neurons of the supraoptic nucleus area were studied by radioautography in the rat after discrete stereotaxic injections of [3H]leucine into this nucleus. Beside a densely labeled pathway running from the nucleus to the posterior pituitary through the internal median eminence, several of the vis...

journal_title：Neuroscience letters

authors： Alonso G,Szafarczyk A,Assenmacher I

更新日期：1986-05-23 00:00:00

abstract：:In the present study, we examined the localizations of canonical transient receptor potential channels (TRPCs) in rat basal ganglia. The dot-like staining pattern of TRPC5 was observed through the globus pallidus (GP) and caudate-putamen. TRPC7 had a strikingly high level of expression in the neuropil in the GP. In th...

journal_title：Neuroscience letters

authors： Chung YH,Kim D,Moon NJ,Oh CS,Lee E,Shin DH,Kim SS,Lee WB,Lee JY,Cha CI

更新日期：2007-07-05 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) was measured for the first time in the brain (substantia nigra, caudate nucleus, putamen, cerebellum, and frontal cortex) from control and parkinsonian patients by highly sensitive sandwich enzyme-linked immunosorbent assay. In both groups, the levels of GDNF in the v...

journal_title：Neuroscience letters

authors： Mogi M,Togari A,Kondo T,Mizuno Y,Kogure O,Kuno S,Ichinose H,Nagatsu T

更新日期：2001-03-16 00:00:00

abstract：:To test the hypothesis that the expression of specific proteins on peripheral terminals of primary afferents can be attenuated by intrathecal administration of antisense oligodeoxynucleotides (ODNs), we administered ODNs antisense to the mu-opioid receptor to male Sprague-Dawley rats via chronically implanted intrathe...

journal_title：Neuroscience letters

authors： Khasar SG,Gold MS,Dastmalchi S,Levine JD

更新日期：1996-10-25 00:00:00

abstract：:Changes in cytokine and chemokine expression during Wallerian degeneration have been studied using nerve transection models, which result in denervation of both myelinating and non-myelinating Schwann cells. Cytokine and chemokine response of non-myelinating Remak Schwann cells to loss of their axons is unknown. In th...

journal_title：Neuroscience letters

authors： Cheepudomwit T,Güzelsu E,Zhou C,Griffin JW,Höke A

更新日期：2008-01-17 00:00:00

abstract：:The underlying mechanism of isoflurane-induced cognitive dysfunction in older individuals is unknown. In this study, the effects of isoflurane exposure on the hippocampal blood-brain barrier (BBB) in aged rats were investigated because it was previously shown that BBB disruption involves in cognitive dysfunction. Twen...

journal_title：Neuroscience letters

authors： Cao Y,Ni C,Li Z,Li L,Liu Y,Wang C,Zhong Y,Cui D,Guo X

更新日期：2015-02-05 00:00:00

abstract：:In Creutzfeldt-Jakob disease (CJD), progressive neuronal cell death probably occurs as a result of a change in conformation of the physiological prion protein (PrP(C)). There is evidence of participation of the lymphatic system and in particular of lymphocytes in the intracorporeal transportation of the pathological p...

journal_title：Neuroscience letters

authors： Ratzka P,Döhlinger S,Cepek L,Steinacker P,Arlt S,Jacobi C,Schröter A,Wiltfang J,Prange H,Kretzschmar HA,Poser S,Otto M

更新日期：2003-05-29 00:00:00

abstract：:The pineal gland is innervated by pinealopetal peptidergic fibers originating in the hypothalamic nuclei which release arginine vasopressin (AVP) and arginine vasotocin (AVT) from their endings. Since the mechanism of AVT action on the pineal signal transduction and melatonin synthesis has not been determined so far, ...

journal_title：Neuroscience letters

authors： Novotná R,Jác M,Hájek I,Novotný I

更新日期：1999-03-05 00:00:00

abstract：:The present experiment investigated cortical responses of native Italian subjects during reading of short sentences including semantic or morphosyntactic violations. Given the specificity of the Italian language in which the sequencing of words is relatively more free than in English or other languages, we investigate...

journal_title：Neuroscience letters

authors： Angrilli A,Penolazzi B,Vespignani F,De Vincenzi M,Job R,Ciccarelli L,Palomba D,Stegagno L

更新日期：2002-03-29 00:00:00

abstract：:Delta9-THC and synthetic cannabinoids produce memory impairment in humans as well as in laboratory animals. The high concentration of cannabinoid CB1 receptors and the presence of endocannabinoids in the hippocampus suggest that a cannabinoid neurochemical system may play a role in learning and memory processes. Thus,...

journal_title：Neuroscience letters

authors： Takahashi RN,Pamplona FA,Fernandes MS

更新日期：2005-06-03 00:00:00

abstract：:We have used in situ hybridization with biotinylated oligonucleotide (antisense) probes and streptavidin-biotinylated alkaline phosphatase method to detect the amount of amyloid beta-protein mRNA in the paraffin-embedded and formalin-fixed brain samples of patients affected by Alzheimer's disease and those of non-affe...

journal_title：Neuroscience letters

authors： Syrjänen S,Heinonen O,Miettinen R,Paljärvi L,Syrjänen K,Riekkinen P

更新日期：1991-09-02 00:00:00

abstract：:In the present study we investigate the inhibitory circuitries that regulate the neuronal activity in the lateral and basal nuclei, which are the main sensory input regions of the amygdala. Axon terminals immunoreactive for parvalbumin, a calcium-binding protein known to colocalize with GABA, were examined in these re...

journal_title：Neuroscience letters

authors： Sorvari H,Miettinen R,Soininen H,Pitkänen A

更新日期：1996-10-18 00:00:00

abstract：:The long-term potentiation (LTP) was studied using rat hippocampal slices in vitro. LTP in mossy fiber-CA3 pyramidal cell synapses was markedly suppressed in slices prepared from rats which had previously received intraventricular injection of pertussis toxin (PTX), compared with the bovine serum albumin-injected cont...

journal_title：Neuroscience letters

authors： Ito I,Okada D,Sugiyama H

更新日期：1988-07-19 00:00:00

abstract：:Samples collected from rabbit neocortical surface during a tetanic stimulation of the neocortex induced neurite growth in PC-12 cells in culture and synaptic long-term potentiation (LTP) in guinea pig hippocampal slices. If these samples were preheated and cooled, or if they were collected in the absence of a tetanic ...

journal_title：Neuroscience letters

authors： Sastry BR,Chirwa SS,May PB,Maretić H

更新日期：1988-08-15 00:00:00

abstract：:Findings from preclinical and clinical research support the involvement of central noradrenergic dysregulation in the etiology of attention deficit hyperactivity disorder (ADHD). Previous studies have suggested that the alpha-2C-adrenergic receptor gene (ADRA2C) is associated with ADHD. The aims of this study were to ...

journal_title：Neuroscience letters

authors： Cho SC,Kim JW,Kim BN,Hwang JW,Shin MS,Park M,Kim SA,Cho DY,Yoo HJ,Chung US,Son JW,Park TW

更新日期：2008-12-03 00:00:00

abstract：:Propofol has been demonstrated as a drug of abuse in humans. Our previous study indicated that dexamethasone, a potent agonist of glucocorticoid receptor (GR), inhibited propofol-maintained rat self-administration behaviors by systematic injection. However, the direct effect of GR in the nucleus accumbens (NAc) on pro...

journal_title：Neuroscience letters

authors： Wu B,Lin W,Wang H,Abdullah T,Wang B,Su Y,Ge RS,Lian Q

更新日期：2018-01-01 00:00:00

abstract：:The physiological role of mGluR1-induced inward current in a Purkinje neuron was studied in a cerebellar slice preparation. In a voltage-clamp condition, application of a mGluR1 agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) induced both the transient and sustained phases of inward currents, which were blocked by simu...

journal_title：Neuroscience letters

authors： Yamakawa Y,Hirano T

更新日期：1999-12-24 00:00:00

abstract：:Insulin-like growth factor binding protein (IGFBP) 7 may be a critical regulator of memory consolidation. This study was performed to assess the relationship between circulating IGFBP7 levels and postoperative cognition dysfunction (POCD) in patients scheduled for elective head and neck carcinoma surgery under general...

journal_title：Neuroscience letters

authors： Jiang J,Chen Z,Liang B,Yan J,Zhang Y,Xu H,Huang Y,Jiang H

更新日期：2015-02-19 00:00:00

abstract：:Rhythmic arm movement significantly suppresses H-reflex amplitude in the soleus (SOL) muscle. This is evidence of neural linkages between the arms and legs which can be exploited during locomotion and have been ascribed to the descending effects of CPGs for arm cycling. However, the generalizability of the effects of ...

journal_title：Neuroscience letters

authors： Dragert K,Zehr EP

更新日期：2009-02-06 00:00:00

abstract：:We describe a novel and powerful extracellular method for the staining of a single neuron identified by electrophysiological criteria. This single-unit technique involves the use of glass micro-electrodes (tip diameter: 1.5-2.5 microns) filled with a saline solution (NaCl; 0.5 M) containing 1.5% of biocytin or Neurobi...

journal_title：Neuroscience letters

authors： Pinault D

更新日期：1994-04-11 00:00:00

abstract：:The streptozotocin (STZ)-induced diabetes model is widely used for the induction of neuropathy in the rat. In this model, diabetic animals often display chronic illness, which raises objections not only on ethical but also on scientific grounds. In this study, the investigators set out to determine the impact of bodyw...

journal_title：Neuroscience letters

authors： Hoybergs YM,Biermans RL,Meert TF

更新日期：2008-05-02 00:00:00

abstract：:Attention-deficit/hyperactivity disorder (ADHD) is highly prevalent in children and adolescents and both environmental and genetic factors play major roles. Polyunsaturated fatty acids (PUFAs) are postulated to contribute to the development of the infant brain and an imbalance in these may increase the risk of ADHD. I...

journal_title：Neuroscience letters

authors： Bartl J,Walitza S,Grünblatt E

更新日期：2014-01-24 00:00:00