当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > The concentrations of serum, plasma and platelet BDNF are all increased by treadmill VO₂max performance in healthy college men.

The concentrations of serum, plasma and platelet BDNF are all increased by treadmill VO₂max performance in healthy college men.

Abstract：

:The most current human-based studies in which brain-derived neurotrophic factor (BDNF) levels in the peripheral blood system are analyzed use it as an indicator that represents BDNF levels in the CNS. However, whether circulating BDNF (serum and plasma) is positively or inversely associated with cardiorespiratory fitness levels (VO(2max)) is still controversial, and no study has done to investigate exercise effects on the concentration of BDNF stored in circulating platelets which, in fact, store a large amount of circulating BDNF. Thus, the purpose of this study was to determine the relation between VO(2max) and all circulating BDNF levels (serum, plasma and platelets) in college male students (N=18; age, 19 ± 1 years; height, 173.22 ± 7.65 cm; weight, 78.25 ± 14.25 kg; body fat percent, 13.82 ± 5.68%). Dual X-ray energy absorptiometry whole body scan was used to measure their body composition. After the overnight fast, all participants were performed VO(2max) test, and their blood was collected at rest and immediately after the exercise. Our data resulted in significant increases in platelet counts and serum, plasma and platelet BDNF levels immediately after the exercise (p<0.01). VO(2max) had a significant negative correlation with serum BDNF, plasma BDNF and platelet BDNF at rest (p<0.05) but a significant positive correlation with serum, plasma BDNF, and platelet BDNF immediately after the exercise (p<0.01). However, our data show no correlation between VO(2max) and platelet count both at rest and immediately after the exercise. In conclusion, this is the first study showing that basal BDNF levels are inversely correlated with cardiorespiratory fitness levels but that the inverse correlations turn into positive correlations with all circulating BDNF levels immediately after the exercise. Moreover, it is the first time to provide evidence that platelet BDNF levels are also positively affected by the exercise. However, future studies will be needed to investigate what tissues provide BDNF into the circulating system and to elucidate the role of circulating BDNF.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Cho HC,Kim J,Kim S,Son YH,Lee N,Jung SH

doi

10.1016/j.neulet.2012.05.025

subject

Has Abstract

pub_date

2012-06-21 00:00:00

pages

78-83

issue

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(12)00661-1

journal_volume

519

pub_type

杂志文章

在线工具

The concentrations of serum, plasma and platelet BDNF are all increased by treadmill VO₂max performance in healthy college men.