Abstract:
:Glial cell line-derived neurotrophic factor (GDNF) was measured for the first time in the brain (substantia nigra, caudate nucleus, putamen, cerebellum, and frontal cortex) from control and parkinsonian patients by highly sensitive sandwich enzyme-linked immunosorbent assay. In both groups, the levels of GDNF in the various brain regions were lower (pg/mg protein) than those of brain-derived growth factor (ng/mg order), and were significantly higher in the nigro-striatal dopaminergic regions (substantia nigra, caudate nucleus, putamen) than in the cerebellum and frontal cortex (P < 0.05). However, the content of GDNF in the dopaminergic regions showed no significant difference between parkinsonian and control patients.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Mogi M,Togari A,Kondo T,Mizuno Y,Kogure O,Kuno S,Ichinose H,Nagatsu Tdoi
10.1016/s0304-3940(01)01577-4keywords:
subject
Has Abstractpub_date
2001-03-16 00:00:00pages
179-81issue
3eissn
0304-3940issn
1872-7972pii
S0304394001015774journal_volume
300pub_type
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