Intranasal administration of NAP, a neuroprotective peptide, decreases anxiety-like behavior in aging mice in the elevated plus maze.

abstract：:8-Hydroxy-2-[di-n-propylamino]-tetralin) (8-OH-DPAT), a 5-HT1A/7 receptor agonist, has a chronobiological effect on the circadian system. To identify how the 8-OH-DPAT exerts this effect, we specifically destroyed the serotonergic (5-HT) fibres connecting the median raphe nuclei (RN) to the suprachiasmatic nuclei (SCN...

journal_title：Neuroscience letters

authors： Schuhler S,Saboureau M,Pitrosky B,Pévet P

更新日期：1998-10-30 00:00:00

abstract：:Herpes simplex virus encephalitis (HSVE) causes elevated morbidity and mortality despite antiviral treatment. Virus-independent mechanisms may perpetuate brain damage. Matrix metalloproteinases (MMPs) target extracellular matrix components. This study describes the protein and mRNA expression of MMP2 and MMP9 in exper...

journal_title：Neuroscience letters

authors： Martínez-Torres FJ,Wagner S,Haas J,Kehm R,Sellner J,Hacke W,Meyding-Lamadé U

更新日期：2004-09-30 00:00:00

abstract：:Neurotrophin 3 (NT3) is a potent neurotrophic factor for promoting remyelination and recovery of neuronal function; upregulation of its expression in the central nervous system (CNS) is thus of major therapeutic importance for neurological deficits. Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix S...

journal_title：Neuroscience letters

authors： Zhang ML,Zhang XJ,Kang J,Zhang HJ,Chen XL,Liu N,Liu SQ,Ma WD,Zhang GX,Zhu L

更新日期：2017-05-10 00:00:00

abstract：:After traumatic brain injury (TBI), the primary insult is followed by a cascade of secondary events which lead to enlargement of the primary lesion and are potentially amenable to therapeutic intervention. Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic propert...

journal_title：Neuroscience letters

authors： Zweckberger K,Simunovic F,Kiening KL,Unterberg AW,Sakowitz OW

更新日期：2011-07-25 00:00:00

abstract：:In order to analyze the elementary mechanisms underlying caffeine-induced epileptiform discharges, hippocampal slices of guinea pigs were exposed to this drug. When the bath concentration of caffeine exceeded 0.2 mM, periodically occurring paroxysmal depolarizations (PD) in CA3 neurons appeared. They were accompanied ...

journal_title：Neuroscience letters

authors： Moraidis I,Bingmann D,Lehmenkühler A,Speckmann EJ

更新日期：1991-08-05 00:00:00

abstract：:Substance P (SP) plays an important role in sensitization of spinal cord neurons. In this study, we investigated SP-induced calcium activities in cultured rat spinal cord neurons with confocal laser scanning microscopy. Our results showed that SP increased [Ca(2+)](i) by calcium entry rather than release from intracel...

journal_title：Neuroscience letters

authors： Zhou ZS,Shu YS,Zhao ZQ

更新日期：2000-06-16 00:00:00

abstract：:Motor and sensory neuropathies with the clinical features of HMSN III (Dejerine-Sottas syndrome, DSS) are etiologically related to heterozygous mutations in either peripheral myelin protein-22 (PMP22) or myelin protein zero (MPZ). Heterozygous mutations in either of these two genes are also responsible for other hered...

journal_title：Neuroscience letters

authors： Stögbauer F,Young P,Wiebusch H,Timmerman V,Kuhlenbäumer G,Nelis E,Ringelstein EB,Kurlemann G,Assmann G,Van Broeckhoven C,Funke H

更新日期：1998-01-02 00:00:00

abstract：:The ability in vivo of the muscarinic agonist, pilocarpine, to increase phosphoinositol (PI) hydrolysis in lithium pretreated rats was investigated by measuring the accumulation of [(3)H]inositol phosphates (IP). As expected, 20 mg/kg s.c. pilocarpine, a muscarinic agonist, increased PI hydrolysis in the striatum, fro...

journal_title：Neuroscience letters

authors： Johnson MP,Kelly GM,Chamberlain M

更新日期：2000-05-05 00:00:00

abstract：:Stress is a major risk factor in drug addiction development and relapse. Virtually all drugs of abuse act by increasing extracellular dopamine levels in the striatum. To gain an understanding of the interaction between stress and drug exposure, we studied the effects of concomitant chronic nicotine and chronic stress ...

journal_title：Neuroscience letters

authors： Salas R,De Biasi M

更新日期：2008-07-25 00:00:00

abstract：:Previous in vivo studies have indicated that both arginine vasopressin (AVP) and angiotensin II (ANG II) can modulate the baroreflex by acting on the area postrema (AP). In the present study, effects of AVP and ANG II on AP neuronal activity were investigated by recording extracellular activity in a rabbit brainstem s...

journal_title：Neuroscience letters

authors： Cai Y,Bishop VS

更新日期：1995-05-05 00:00:00

abstract：:The aim of the study was to investigate whether repetitive/temporal hypoxia up-regulated P-glycoprotein (P-gp) in cultured rat brain microvascular endothelial cells (rBMECs). Cultured rBMECs were used as in vitro blood brain barrier (BBB) model. Cells reached confluence were subjected to temporal hypoxic exposure. Und...

journal_title：Neuroscience letters

authors： Xiao-Dong L,Zhi-Hong Y,Hui-Wen Y

更新日期：2008-02-27 00:00:00

abstract：:Free radical generation and release from the cerebral hemispheres of rats subjected to four-vessel occlusion elicited cerebral ischemia/reperfusion was monitored using a cortical cup technique with the spin-trapping agent alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN). Electron spin resonance (ESR) was used to d...

journal_title：Neuroscience letters

authors： Phillis JW,Sen S,Cao X

更新日期：1994-03-14 00:00:00

abstract：:The aim of this study was to investigate the adaptive process in the coupling between visual information and body sway in children postural control. Twenty-seven children from 4-, 8- and 12-year-olds and ten adults stood upright inside of a moving room. In the first 2 min, the room was moved continuously at frequency ...

journal_title：Neuroscience letters

authors： Rinaldi NM,Polastri PF,Barela JA

更新日期：2009-12-31 00:00:00

abstract：:The effects of the group III mGluR agonist, L-2-amino-4-phosphonobutyrate (L-AP4), on depolarization-stimulated cGMP levels in adult rat cerebellar slices were determined. L-AP4 elicited a concentration-dependent, complete inhibition of cGMP formation stimulated by 4-aminopyridine (4-AP; 1 mM), yielding an IC50 value ...

journal_title：Neuroscience letters

authors： Cartmell J,Kemp JA,Mutel V

更新日期：1997-06-13 00:00:00

abstract：:Cellular origins of methylarginines are not precisely known but the presence of free methyl and dimethylarginines in the brain were reported. We have investigated the circulating concentrations of asymmetrical dimethylarginine NG,NG-dimethylarginine (ADMA), NG,NG-dimethylarginine (SDMA), nitrate and nitrite levels in ...

journal_title：Neuroscience letters

authors： Das I,Khan NS,Puri BK,Hirsch SR

更新日期：1996-09-13 00:00:00

abstract：:Alterations in dendritic spine densities and morphologies have been correlated with the abnormal functioning of the synapse. Specifically the metabotropic glutamate receptor 5 (mGluR5) has been implicated in dendrogenesis and spineogenesis, since its activation triggers various signaling cascades that have been demons...

journal_title：Neuroscience letters

authors： Chen CC,Lu HC,Brumberg JC

更新日期：2012-08-22 00:00:00

abstract：:Sorbitol accumulation and transmembrane efflux in JS1 schwannoma cells were examined during osmotic stress in the presence of a sorbitol dehydrogenase (SD) inhibitor and following return to iso-osmotic conditions. SD inhibition promoted sorbitol accumulation under hyperglycemic and/or hyperosmotic conditions, and sorb...

journal_title：Neuroscience letters

authors： Mizisin AP,Li L,Calcutt NA

更新日期：1997-06-20 00:00:00

abstract：:Current theories of orbitofrontal cortex (OFC) function suggest that this region should participate in the generation of error-related signals associated with the outcomes of actions. We investigated the impact of lesions to OFC on the error-related negativity (ERN), an electrophysiological marker of performance monit...

journal_title：Neuroscience letters

authors： Turken AU,Swick D

更新日期：2008-08-15 00:00:00

abstract：:Coenzyme Q(10) (CoQ(10)) exerts neuroprotective effects in several in vivo and in vitro models of neurodegenerative disorders. However, the mechanisms of action are not fully understood. The aim in this study was to investigate whether oral administration of CoQ(10) could inhibit cytochrome c (cyt c) release from mito...

journal_title：Neuroscience letters

authors： Mitsumoto Y,Kobayashi S,Matsushima H,Muroyama A,Yoshimura I

更新日期：2009-09-29 00:00:00

abstract：:Neural stem cells (NSCs) have been the focus of an intensive effort to direct their differentiation in vitro towards desired neuronal phenotypes for cell replacement therapies. It is thought that NSCs derived from older embryos have limited neurogenic capacity and are restricted towards an astroglial fate. This idea i...

journal_title：Neuroscience letters

authors： Hegarty SV,Spitere K,Sullivan AM,O'Keeffe GW

更新日期：2014-01-24 00:00:00

abstract：:The effect of the neuropeptide, substance P, on the transport of D-[(3)H]aspartate into rat striatal synaptosomes was studied. Almost 90% of the total transport of D-[(3)H]aspartate was sodium-dependent and the maximum rate (V(max)) of this transport was increased by 34% of control by 2.5 nM substance P (EC(50)=0.52 n...

journal_title：Neuroscience letters

authors： Healy J,Downes A,McBean GJ

更新日期：2000-08-25 00:00:00

abstract：:Polypeptides phosphorylated in vivo in Drosophila mutants defective in learning and memory, were characterized by polyacrylamide gel electrophoresis of subcellular fractions obtained by phase partitioning in Triton X-114 [3]. In the mutants turnip, dunce and Shaker, one or more bands at a molecular weight range of 50-...

journal_title：Neuroscience letters

authors： Buxbaum JD,Dudai Y

更新日期：1989-10-09 00:00:00

abstract：:We examined the distribution of ferric ion-ferrocyanide stain (a marker for excitable regions of myelinated fibers) in the lead-induced demyelinating neuropathy of the rat. By electron microscopy, we found that paranodal degeneration resulted in spreading of the reaction product from nodal to internodal axolemma. Duri...

journal_title：Neuroscience letters

authors： Coria F,Silos I,Fernandez R,Monton F,Lafarga M

更新日期：1985-08-05 00:00:00

abstract：:The DNA-damaging effect of the potent dopaminergic neurotoxin 'TaClo' (1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline) is reported. After irradiation (300 nm, 350 nm) of cell-free pBR322 DNA in the presence of TaClo, single-strand breaks were observed by gel electrophoresis. It seems likely that TaClo undergoes a...

journal_title：Neuroscience letters

authors： Bringmann G,Münchbach M,Feineis D,Faulhaber K,Ihmels H

更新日期：2001-05-18 00:00:00

abstract：:Dinucleotide repeat polymorphism has been observed in the promoter of the alpha-synuclein (alpha-SYN)/NAC precursor protein (NACP) gene. Alpha-SYN/NACP allele 3 (described by Xia et al. (Ann. Neurol., 40 (1996) 207), equivalent to allele 1 described by Krüger et al. (Ann. Neurol. 45 (1999) 611) is reported to be signi...

journal_title：Neuroscience letters

authors： Izumi Y,Morino H,Oda M,Maruyama H,Udaka F,Kameyama M,Nakamura S,Kawakami H

更新日期：2001-03-09 00:00:00

abstract：:We raised polyclonal antibodies against a gene product responsible for late infantile neuronal ceroid lipofuscinosis (CLN2). By Western blotting, all three antisera recognized the CLN2 protein at approximately 49 kDa in human brain homogenates. Immunohistochemistry using the antisera demonstrated the granular labellin...

journal_title：Neuroscience letters

authors： Oka A,Kurachi Y,Mizuguchi M,Hayashi M,Takashima S

更新日期：1998-11-27 00:00:00

abstract：:We investigated the role of 5-HT(2A) and 5-HT(2C) receptors in atypical absence seizures (AAS) induced by trans-1,4-bis[2-chloro-benzylaminomethyl] cyclohexane, dihydrocholoride (AY-9944). The total duration and number and mean duration of the spontaneous bursts of slow spike-and-wave discharges (SSWD) that characteri...

journal_title：Neuroscience letters

authors： Bercovici E,Cortez MA,Snead OC 3rd

更新日期：2007-05-11 00:00:00

abstract：:This experiment has been designed to evaluate the basal serum BDNF level and memory performance, and also the change in BDNF in response to acute aerobic and anaerobic training in athletes and sedentary groups. Nineteen middle aged elite athletes (45-65 years) who used to be competing at domestic championship for more...

journal_title：Neuroscience letters

authors： Babaei P,Damirchi A,Mehdipoor M,Tehrani BS

更新日期：2014-04-30 00:00:00

abstract：:Drug addiction is a process that transits from recreative and regular drug use into compulsive drug use. The two patterns of drug use, controlled drug intake and escalated drug intake, represent different stages in the development of drug addiction; and escalation of drug use is a hallmark of addiction. Accumulating s...

journal_title：Neuroscience letters

authors： Du HY,Cao DN,Chen Y,Wang L,Wu N,Li J

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:Brain function relies on the capacity of neurons to locally modulate each other at the level of synapses. Therefore, the exosomal pathway may constitute a well-designed mechanism for local and systemic interneuronal transfer of information within functional brain networks. Exosomes bind to and are endocytose...

journal_title：Neuroscience letters

authors： Yu X,Abdul M,Fan BQ,Zhang L,Lin X,Wu Y,Fu H,Lin Q,Meng H

更新日期：2020-04-01 00:00:00