Abstract:
:Neurite outgrowth is elicited from whole explants or dissociated neurons of 8--10-day-old chick embryo sensory, dorsal root ganglia when cultured in the presence of a high speed supernatant fraction (105,000 g) from homogenates of chick or rat heart, liver or brain. The neurite promoting activity is not identical to mouse nerve growth factor (NGF) and is non-dialyzable. Expression of this neurogenic factor would appear to be developmentally regulated as its activity is barely detectable in organs from 6--9-day-old embryos but specific activity rises dramatically in homogenates of organs from embryos of greater than 11 days incubation. Greatest activity is found in chick heart and rat brain with only trace levels in lung or kidney and none in spinal cord.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lindsay RM,Tarbit Jdoi
10.1016/0304-3940(79)96061-0subject
Has Abstractpub_date
1979-05-01 00:00:00pages
195-200issue
2-3eissn
0304-3940issn
1872-7972pii
0304-3940(79)96061-0journal_volume
12pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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