Suppression of arterial pressure, heart rate and cardiac contractility following microinjection of kainic acid into the nucleus ambiguus of the rat.

abstract：:Nerve guide implants approved for human application in the peripheral nervous system generally fail to bridge lesion gaps longer than 2 cm and cannot match the clinical performance of autologous nerve transplants. Since current synthetic implants are simply hollow tubes, we aim to recreate the native microarchitecture...

journal_title：Neuroscience letters

authors： Nichterwitz S,Hoffmann N,Hajosch R,Oberhoffner S,Schlosshauer B

更新日期：2010-10-29 00:00:00

abstract：:Hypoxia is one of the important physiological stimuli that are often associated with a variety of pathological states such as ischemia, respiratory diseases, and tumorigenesis. In the central nervous system, hypoxia that is accompanied by cerebral ischemia not only causes neuronal cell injury, but may also induce path...

journal_title：Neuroscience letters

authors： Suk K

更新日期：2004-08-12 00:00:00

abstract：:Using immunohistochemistry we studied the presence of calbindin in myenteric neurones of the guinea-pig stomach. A rabbit anti recombinant rat calbindin-D28k (CALB) stained 12, 12 and 25% of all myenteric neurones in the fundus, corpus and antrum, respectively. A rabbit anti recombinant human CALB stained 4, 4 and 16%...

journal_title：Neuroscience letters

authors： Reiche D,Pfannkuche H,Michel K,Hoppe S,Schemann M

更新日期：1999-07-30 00:00:00

abstract：:The pathological features of Alzheimer's disease include deposition of amyloid-beta (Abeta) containing plaques and increases in the expression of cyclin-dependent kinase (CDK) enzymes. Chemical inhibition of CDKs prevents the neurotoxicity of the Abeta peptide. The activity of these kinases requires the binding of a c...

journal_title：Neuroscience letters

authors： Milton NG

更新日期：2002-04-05 00:00:00

abstract：:The high-affinity, sodium-dependent uptake of dopamine (DA) was inhibited by the pretreatment of synaptosomes with neuraminidase from Vibrio cholerae. The inhibition was of a non-competitive type, resulting in a 40% decrease of Vmax. Neither basal nor depolarization-stimulated release of DA was affected. Treatment of ...

journal_title：Neuroscience letters

authors： Zaleska MM,Erecińska M

更新日期：1987-11-10 00:00:00

abstract：:Focal cortical dysplasia (FCD) is an important cause of refractory epilepsy in humans. The origin of its pathognomonic abnormal cell types and the links between abnormal cell morphology and epileptogenicity remain unknown. The developmentally-regulated kinase cdk5 and its neuronal activator p35 are known to be central...

journal_title：Neuroscience letters

authors： Sisodiya SM,Thom M,Lin WR,Bajaj NP,Cross JH,Harding BN

更新日期：2002-08-16 00:00:00

abstract：:The antagonism of some benzodiazepine (Bz) actions by physostigmine was investigated in 4 Papio papio baboons. As a model of these actions, the myoclonus induced in this species by clonazepam i.m. administration was used. The baboon develops, 20-30 min after Bz i.m. injection, a non-epileptic myoclonus characterized b...

journal_title：Neuroscience letters

authors： Rektor I,Bryere P,Valin A,Silva-Barrat C,Naquet R,Menini C

更新日期：1984-11-23 00:00:00

abstract：:We are attempting to determine the neuronal factors that influence upper airway patency during sleep in the elderly. Serotonin has a facilitatory effect on hypoglossal motoneurons that innervate the tongue, and manipulations of the serotonergic system alter airway patency. We hypothesized that age-associated changes i...

journal_title：Neuroscience letters

authors： Behan M,Brownfield MS

更新日期：1999-05-28 00:00:00

abstract：:Inflammatory responses have been shown to modulate the pattern and degree of ischemic injury. Previously, we demonstrated that intracorpus callosum microinjection of lipopolysaccharide (LPS, a well-known endotoxin) markedly induced inflammatory responses confined to ipsilateral hemisphere and aggravated cerebral ische...

journal_title：Neuroscience letters

authors： Cho GS,Lee JC,Ju C,Kim C,Kim WK

更新日期：2013-03-22 00:00:00

abstract：:CSF-A beta 42 may be a marker of Alzheimer's disease (AD). A decreased level of CSF-A beta 42 is consistently found in AD and has been suggested to be related to the deposition of amyloid plaques in the brain. However, low CSF-A beta 42 levels have also been found in disorders devoid of plaques, for instance Creutzfel...

journal_title：Neuroscience letters

authors： Sjögren M,Gisslén M,Vanmechelen E,Blennow K

更新日期：2001-11-13 00:00:00

abstract：:Both feedforward and feedback mechanisms are used to ensure accurate movements. Feedback information comes primarily from vision and proprioception; the relative contributions of these modalities to on-line control of action and internal model maintenance remain unclear. We report data from an experiment in which a ch...

journal_title：Neuroscience letters

authors： Medina J,Jax SA,Coslett HB

更新日期：2009-02-27 00:00:00

abstract：:This study forms part of an ongoing investigation of pyramidal cell structure in the cingulate cortex of primates. Recently we have demonstrated that layer III pyramidal cells in the anterior cingulate gyrus are considerably larger, more branched and more spinous than those in the posterior cingulate gyrus (areas 24 a...

journal_title：Neuroscience letters

authors： Elston GN,Benavides-Piccione R,Elston A,DeFelipe J,Manger P

更新日期：2005-10-28 00:00:00

abstract：:Intracerebroventricular injection of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alphaTHP) induced catalepsy in mice, within less than 10 min of its administration, which lasted for more than 3 h. This catalepsy was reversed by i.p. administration of picrotoxin, bicuculline, bromocriptine and levodo...

journal_title：Neuroscience letters

authors： Khisti RT,Mandhane SN,Chopde CT

更新日期：1998-07-24 00:00:00

abstract：:Complement is implicated in the pathogenesis of inflammatory disorders of the central nervous system (CNS), like multiple sclerosis, Alzheimer's disease, and trauma. The anaphylatoxins C3a and C5a are thought to be the major contributors to complement-mediated inflammation in the CNS, likely mediating their effects vi...

journal_title：Neuroscience letters

authors： Boos L,Szalai AJ,Barnum SR

更新日期：2005-10-21 00:00:00

abstract：:The retinohypothalamic tract (RHT) in the Djungarian hamster Phodopus sungorus was studied using anterograde neuronal transport of cholera toxin subunit B (CTB) following unilateral intraocular injection. A major projection terminates bilaterally in the hypothalamic suprachiasmatic nuclei (SCN). In the anterior ventra...

journal_title：Neuroscience letters

authors： Reuss S,Decker K,Hödl P,Sraka S

更新日期：1994-06-06 00:00:00

abstract：:Individual activation of nicotinic acetylcholine receptor (nAChR) or nitric oxide (NO) synthase in the dorsal facial area (DFA) increases blood flow of common carotid artery (CCA) supplying intra- and extra-cranial tissues. We investigated whether the activation of nAChR initiated the activation of NO synthase and gua...

journal_title：Neuroscience letters

authors： Gong CL,Leung YM,Huang YP,Lin NN,Hung YW,Lee TJ,Kuo JS

更新日期：2010-12-17 00:00:00

abstract：:A dose-dependent loss of vanilloid receptors (specific [3H]resiniferatoxin binding sites) was found in sensory ganglia of rats 24 h after s.c. administration of resiniferatoxin (RTX), an ultrapotent capsaicin analog. This receptor loss displayed an ED50 of 30 micrograms/kg both in dorsal root and trigeminal ganglia; t...

journal_title：Neuroscience letters

authors： Szallasi A,Blumberg PM

更新日期：1992-06-08 00:00:00

abstract：:Application of NMDA, or agents releasing nitric oxide (NO), onto the dendrites of hippocampal granule cells increased the levels of the mRNA encoding MAP2, a cytoskeletal component induced during periods of neurite outgrowth. Furthermore, local increases in the hybridisation signal in the molecular layer, representing...

journal_title：Neuroscience letters

authors： Johnston HM,Morris BJ

更新日期：1994-08-15 00:00:00

abstract：:Aripiprazole, a novel atypical antipsychotic drug, can significantly increase dopamine (DA) levels in the prefrontal cortex of rats, but only at low doses below 1mg/kg. The aim of the present work was to test the effect of aripiprazole (0, 0.1, 0.3, 3 and 30 mg/kg, i.p.) on extracellular levels of monoamines in the pr...

journal_title：Neuroscience letters

authors： Zocchi A,Fabbri D,Heidbreder CA

更新日期：2005-10-28 00:00:00

abstract：:Intracerebral hemorrhage is associated with stroke and head trauma. The purpose of this study was to study brain inflammation and cell death in adult rats 1 h to 4 weeks after injection of blood into the striatum. Terminal dUTP nick-end-labeling positive dying cells were evident 4 h to 4 weeks post-hemorrhage. Neutrop...

journal_title：Neuroscience letters

authors： Xue M,Del Bigio MR

更新日期：2000-04-14 00:00:00

abstract：:The regional cerebral blood flow (rCBF) was measured with positron emission tomography in eight normal volunteers with the purpose of measuring rCBF changes related to the comprehension of an unfamiliar spoken languages. When attempting to comprehend the meaning of words, the left hemisphere showed dominant increases ...

journal_title：Neuroscience letters

authors： Kawashima R,Itoh M,Hatazawa J,Miyazawa H,Yamada K,Matsuzawa T,Fukuda H

更新日期：1993-10-14 00:00:00

abstract：:Superfusion of the isolated spinal cord of neonatal rats (4-9 days postpartum) with physiological medium containing 2-chloroadenosine (2-CA) or anoxic medium (equilibrated with 95% N2-5% CO2) depressed the evoked monosynaptic reflex (MSR) recorded extracellularly from a ventral spinal root. The effectiveness of 2-CA o...

journal_title：Neuroscience letters

authors： Lloyd HG,Perkins A,Spence I

更新日期：1989-06-19 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has an antalgic effect on acute experimental pain in healthy volunteers. Many published studies have used online stimulation (i.e., tDCS performed during painful stimulation). On the other hand, daily tDCS sessions have been proposed as ...

journal_title：Neuroscience letters

authors： Brasil-Neto JP,Iannone A,Caixeta FV,Cavendish BA,de Mello Cruz AP,Buratto LG

更新日期：2020-09-25 00:00:00

abstract：:This report concerns an ultrastructural study of the synapses present on the surface of somata of normal-looking Betz cells in the fifth layer of motor cortex of seven patients with amyotrophic lateral sclerosis (ALS). Specimens from 12 age-matched, neurologically normal control individuals were included for compariso...

journal_title：Neuroscience letters

authors： Sasaki S,Iwata M

更新日期：1999-06-11 00:00:00

abstract：:The anatomical relationships between pro-opiomelanocortin-containing axons and serotonin neurons in the nucleus raphe dorsalis (NRD) of the rat were examined at the light microscope level with antibodies against CLIP (corticotropin-like intermediate lobe peptide), alpha-MSH (alpha-melanocyte-stimulating hormone) and s...

journal_title：Neuroscience letters

authors： Zheng Z,Léger L,Cespuglio R,Jouvet M

更新日期：1991-09-02 00:00:00

abstract：:Accumulating evidence indicates that somatostatin (SS) is a key substance for the circadian rhythm of rodents. In the present study, we investigated whether SS mRNA coexists with arginine-vasopressin (AVP) mRNA, vasoactive intestinal peptide/peptide histidine isoleucine amide (VIP/PHI) mRNA and glutamate decarboxylase...

journal_title：Neuroscience letters

authors： Tanaka M,Okamura H,Matsuda T,Shigeyoshi Y,Hisa Y,Chihara K,Ibata Y

更新日期：1996-09-06 00:00:00

abstract：:Crayfish muscle fibres were voltage-clamped at E = -80 mV membrane potential and superfused for about 10 min with Li+ saline (Na+ replaced by Li+) which contained picrotoxin to block inhibitory post-synaptic currents. Addition of veratridine (100 mumol/l) caused intense fluctuations in the voltage clamp current within...

journal_title：Neuroscience letters

authors： Finger W,Martin C

更新日期：1987-12-16 00:00:00

abstract：:The goal of the present study was to explore the relation between speed-accuracy trade-off phenomena and action kinematics in the case of pointing under isometric conditions. Increasing task difficulty resulted in a linear increase in movement time (as predicted by Fitts' law) and in systematic changes in the spatio-t...

journal_title：Neuroscience letters

authors： Billon M,Bootsma RJ,Mottet D

更新日期：2000-05-26 00:00:00

abstract：:Purinoceptor agonists produced potassium currents with the order of potency: ATP > adenosine = ADP = AMP > beta,gamma-methylene ATP, while a small response or no response was induced by 2-methylthio ATP, UTP, or alpha,beta-methylene ATP. The response induced by beta,gamma-methylene ATP was completely inhibited in the ...

journal_title：Neuroscience letters

authors： Matsuoka T,Nishizaki T,Nomura T,Mori M,Okada Y

更新日期：1998-05-29 00:00:00

abstract：:Cocaine administration has been shown to affect several sites in the limbic forebrain. The nucleus accumbens has been implicated as an important site for the reinforcing aspects of this drug whereas, the amygdala and hippocampus may be more involved in drug conditioning and/or drug induced changes in the perception of...

journal_title：Neuroscience letters

authors： Robledo P,Kaneko WM,Ehlers CL

更新日期：1993-09-17 00:00:00