Age-related changes in serotonin in the hypoglossal nucleus of rat: implications for sleep-disordered breathing.

Abstract:

:We are attempting to determine the neuronal factors that influence upper airway patency during sleep in the elderly. Serotonin has a facilitatory effect on hypoglossal motoneurons that innervate the tongue, and manipulations of the serotonergic system alter airway patency. We hypothesized that age-associated changes in serotonergic input to the hypoglossal nucleus might be a factor in the increased susceptibility to sleep-disordered breathing in the elderly. We used light microscopic immunocytochemistry to study the distribution of serotonin in the hypoglossal nucleus in young and old rats. Rats > 18 months had fewer serotonin immunoreactive axons and boutons in the hypoglossal nucleus than rats < 6 months. These data suggest that normal aging may result in a change in the availability of serotonin that results in decreased facilitation of hypoglossal motoneurons.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Behan M,Brownfield MS

doi

10.1016/s0304-3940(99)00337-7

keywords:

subject

Has Abstract

pub_date

1999-05-28 00:00:00

pages

133-6

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(99)00337-7

journal_volume

267

pub_type

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