Abstract:
:Focal cortical dysplasia (FCD) is an important cause of refractory epilepsy in humans. The origin of its pathognomonic abnormal cell types and the links between abnormal cell morphology and epileptogenicity remain unknown. The developmentally-regulated kinase cdk5 and its neuronal activator p35 are known to be central to a number of key components in neuronal development, cellular morphology, cytoskeletal function, synaptic plasticity and neurodegeneration. Here we examine eight cases of human FCD for expression of cdk5. We show abnormal cdk5 immunoreactivity and aggregation of protein suggesting alterations in cdk5 may also be involved in this important epileptogenic human pathology.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sisodiya SM,Thom M,Lin WR,Bajaj NP,Cross JH,Harding BNdoi
10.1016/s0304-3940(02)00520-7keywords:
subject
Has Abstractpub_date
2002-08-16 00:00:00pages
217-20issue
3eissn
0304-3940issn
1872-7972pii
S0304394002005207journal_volume
328pub_type
杂志文章abstract::The strict photoperiodic dependence of gonadotropic function observed in mink provides an excellent physiological model for studying the activity of GnRH hypothalamic neurons. In mink, exposure to more than 10 h light inhibits the activity of this neurohormonal system. Melatonin plays an essential role in this type of...
journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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pub_type: 杂志文章
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journal_title:Neuroscience letters
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