Abstract:
:Intracerebral hemorrhage is associated with stroke and head trauma. The purpose of this study was to study brain inflammation and cell death in adult rats 1 h to 4 weeks after injection of blood into the striatum. Terminal dUTP nick-end-labeling positive dying cells were evident 4 h to 4 weeks post-hemorrhage. Neutrophil infiltration was brief and peaked at 48 h. CD8a immunoreactive lymphocytes, possibly natural killer cells, became apparent at 48 h and persisted for 1 week. Microglial reaction was evident at 4 h and persisted for 4 weeks. We conclude that extravascular blood causes a mixed inflammatory cell reaction in brains that is maximal from 48-72 h following hemorrhage. This is associated with death of brain cells over a prolonged period of at least 4 weeks.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Xue M,Del Bigio MRdoi
10.1016/s0304-3940(00)00971-xkeywords:
subject
Has Abstractpub_date
2000-04-14 00:00:00pages
230-2issue
3eissn
0304-3940issn
1872-7972pii
S030439400000971Xjournal_volume
283pub_type
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