Abstract:
:Expression by rat motoneurons of mRNAs for the alpha subunit of the ciliary neurotrophic factor receptor (CNTFR alpha), receptor tyrosine kinase-C (trkC), calcitonin gene-related peptide (CGRP) and galanin was studied by in situ hybridisation, 6d after rat facial nerve transection on postnatal day 1. Similar numbers of motoneurons in both injured and non-injured nuclei hybridised with all probes, despite a reduction in total numbers of motoneurons ipsilaterally. When ciliary neurotrophic factor (CNTF) was applied to the proximal nerve, twice as many motoneurons in the injured nucleus hybridised with the CNTFR alpha probe ipsilaterally compared to the non-injured nucleus, while motoneuronal loss was not evident. These results indicate that survival of motoneurons after neonatal axotomy and CNTF treatment is associated with increased CNTF receptor alpha expression.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Duberley RM,Johnson IPdoi
10.1016/s0304-3940(96)13124-4subject
Has Abstractpub_date
1996-11-08 00:00:00pages
188-92issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(96)13124-4journal_volume
218pub_type
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(80)90056-7
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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pub_type: 杂志文章
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更新日期:1986-12-23 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2001-04-06 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1995-06-16 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2007-06-08 00:00:00
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journal_title:Neuroscience letters
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更新日期:2015-01-01 00:00:00
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更新日期:1983-06-30 00:00:00